UCL Institute of Neurology and UCL Institute of Healthy Ageing Joint Seminar
Jun 18, 2018 11:30 AM
End: Jun 18, 2018 12:30 PM
Title: "The immune-brain interface in ageing and brain disorders"
Speaker: Professor Katrin Andreasson - Stanford University, Neurology and Neurological Sciences (lab page)
Venue: Gilliatt LT (ground floor), UCL Institute of Neurology, Queen Square House (map)
Host: Nathan Woodling (email)
Abstract: Recent advances in human genetics have highlighted a causal role for a disrupted immune response in disease pathogenesis. An injurious immune response may be a common denominator across many neurological disorders, both acute (brain trauma or stroke) and chronic (epilepsy, Parkinson’s disease, or Alzheimer's disease).
In this talk, I will discuss projects from my lab investigating specific innate immune pathways including the kynurenine pathway, prostaglandin signalling, and TREM1 signalling. Our work has shown that these pathways are altered in ageing and in models of stroke and Alzheimer's disease, where they appear to be a major driving force for neurodegeneration.