Speaker: Professor Carol Robinson - University of Oxford (research profile)
Title: "Membrane proteins - the lipid connection"
Venue: G29 JZ Young LT, Anatomy Building (map)
Host: Dr Kostas Thalassinos (email)
The lecture will be followed by a wine reception in the JBS Haldane Hub – everyone is welcome to come along and meet Professor Robinson.
- Talk Abstract
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The realisation that the lipid environment is crucial for maintaining the structure and function of membrane proteins prompts new methods to understand lipid interactions. One such method, mass spectrometry, is emerging with the potential to monitor different modes of lipid binding to membrane protein complexes. Initial studies monitored the addition of lipids and deduced the kinetic and thermodynamic effects of lipid binding to proteins. Recently however, we have focused on identifying lipids already present, explicitly in plugs, annular rings or cavities. In this lecture I will provide an overview of recent advances in mass spectrometry, with a particular focus on the distinction of the various modes of lipid binding, their implications for structure and function, as well as new directions that lie ahead.
- Biography
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Professor Dame Carol Robinson:
Carol
holds the Chair of Dr Lee’s Professor of Chemistry at the University of
Oxford. She is recognised for using mass spectrometry to further
research into the 3D structure of proteins and their complexes.
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