Close
Learn how to design next generation mammalian cell processes and how to evaluate the impact of emerging and disruptive technologies.
The increasing number of mAb and biosimilar products in the market has intensified competition and accelerated the rate of innovation across the sector.
This module aims to present, evaluate and consolidate the latest developments through a series of lectures and interactive case studies that will enable you to:
- Understand the fundamentals governing productivity and product quality at industrial scale
- Assess the suitability of single use technologies as a replacement for existing unit operations
- Learn how to develop robust and reliable scale down models to assist in process development and characterization
- Learn about the latest trends in cell line development and media formulation
- Learn about process intensification, continuous bioprocessing and its current status and how to assess the impact of disruptive technologies
- Explore how mathematical models can be used to enhance process understanding and improve activities in process optimization
This MBI is recommended for:
This course is designed for scientists, engineers and managers working in the biotechnology and biopharmaceutical sector that are involved or interact with people in Process Development, Process Intensification, Process Characterization, Manufacturing and Quality Control.
Delegates have included:
- Molecular biologists
- Process engineers
- Cell biologists
- Analytical scientists
- Project managers
- Chief scientific officers
- Module Leader
Alexandros (Alex) Kiparissides is an Honorary Professor in Biochemical Engineering at University College London, having joined UCL in 2015. Alex obtained a Diploma in Chemical Engineering from the Aristotle University of Thessaloniki (Greece) and a PhD in Bioprocess Systems Engineering from Imperial College London. Subsequently Alex was awarded with a post-doctoral fellowship at the École Polytechnique Fédérale de Lausanne (EPFL, Switzerland). His research group explores the boundaries between traditional Process Systems Engineering, Systems Biology and Applied Biotechnology. The general theme of his research is the development of an integrated methodology combining Multi-scale Modelling and wet-lab experiments in order to:
• Better understand cell physiology and metabolism under industrial bioprocessing conditions
• Identify key parameters affecting culture efficiency at the metabolic, bioprocess and reactor design level
• Enable the model based design and optimisation of industrial scale bioreactors- Programme Outline
Day 1
- Scale-down Approaches to Bioprocess Development
- Scaling Up/Down of Mammalian Cell Processes: Fundamentals and Case Studies
- Bioprocess Systems Engineering: The benefits & limitations of modelling
- Optimisation and Scale-Up of Protein Free Processes for Antibody Production
- Digital Design of Chromatographic Bioseparations in Mammalian Cell Processes
- Proteins from Mammalian Cells. Where are we? Where might we go?
- High Throughput/Automation for Bioprocess Development
Day 2
- Operational and Development Strategies to Optimise Process Economics
- Workshop: Strategies to Optimise Process Economics
- Process Interactions: Variability during the harvest and recovery of biopharmaceuticals from mammalian cell hosts
- CQAs of Recombinant Therapeutics Proteins and their Interplay with Upstream Process Conditions
Day 3
- Alleviating Key Challenges Facing Mammalian Cell Technologies using Antha
- Panel Discussion: How to Implement Continuous and Where Can it Benefit?
- Synthetic Biology: Advances and Applications in Mammalian Cell Processing
- Advances in Transient and Stable Expression Platforms
- Genome Scale Science for CHO