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UCL Department of Biochemical Engineering

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Fluid Flow and Mixing in Bioprocesses

Course Code
BENG103P
Level One
Credits
0.5
Course Tutor
Dr Marco Marques
Assessment Criteria
Coursework: 20%
Unseen Examination: 80%
Prerequisites
None

Aims

To provide you with an introduction to the basic transport phenomena required to analyse and design processes handling labile biological materials.

Learning Hours

Includes:

Seminars/problem classes/tutorials: 32h
Laboratory/studio: 18h
Independent project work: 10h
E-learning/tutor led contact: 30h
E-learning/student led contact: 10h

Syllabus

  • Rheology: Viscosity and shear stress. Newtonian and non-Newtonian fluids. Rheology of fermentation broths.
  • Fluid flow in pipes: Predicting flow characteristics in pipe systems. Calculating head in a pipework system. Case study. Pumping of Liquids. Fluid flow and pressure measurement.
  • Fluid flow in packed columns: Flow through porous media. Determining column porosity. Estimating pressure drops in packed beds. Effect of particle shape. Case studies- Pumping and flow in chromatography columns.
  • Bioreactor mixing and scale-up/down: Flow patterns in stirred tanks. Quantification of mixing phenomena in stirred vessels. Case Study 1 – Design of batch sterilisation vessel and small aerated pilot fermenter. Influence of power input on oxygen transfer. Case Study 2 -  Scale-up/down of fermenters.