Biochemical Engineering


Current Challenges in Mammalian Cell Processing

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21-24 January 2019

Learn how to design next generation mammalian cell processes and how to evaluate the impact of emerging and disruptive technologies.

The increasing number of mAb and biosimilar products in the market has intensified competition and accelerated the rate of innovation across the sector.

This module aims to present, evaluate and consolidate the latest developments through a series of lectures and interactive case
studies that will enable you to:

  • Understand the fundamentals governing productivity and product quality at industrial scale
  • Assess the suitability of single use technologies as a replacement for existing unit operations
  • Learn how to develop robust and reliable scale down models to assist in process development and characterization
  • Learn about the latest trends in cell line development and media formulation
  • Learn about process intensification, continuous bioprocessing and its current status and how to assess the impact of disruptive technologies
  • Explore how mathematical models can be used to enhance process understanding and improve activities in process optimization

Who should attend?

The course is designed for scientists, engineers and managers working in the biotech/biopharma sector that are involved or interact with people in Process Development, Process Intensification, Process Characterization, Manufacturing and Quality Control.

Typically, delegates are:

Molecular biologists, process engineers, cell biologists, analytical scientists, project managers and chief scientific officers.


Day 1
• Historic perspective of mammalian cell culture
• Rapid cell line development
• The design of highly productive processes
• Case Study: Strategies to optimise process economics

Day 2
• Case study: from development to production
• Challenges for mammalian cell culture analytics
• Critical quality attributes of recombinant therapeutic
• Scale-down approaches to bioprocess development
• Use of mathmatical modes to improve bioprocesses

Day 3
• Engineering fundamentals and mixing in single-use bioreactors
• Tutorial: Technology transfer and scale translation
• Developing the next generation mAbs processing enabled by single-use
• Workshop: Single-use bioprocess economics
• The impact of upstream production on downstream processing

UCL Experts

Daniel Bracewell
Suzanne Farid
Gary Lye
Martina Micheletti
Darren Nesbeth

Previous Expert Speakers

John Birch, Consultant - Module Leader
Suzanne Aldington, Lonza Biologics
Andrew Brown, Allergan
Lekan Daramola, MedImmune
Ludovic Duponchel, University of Lille
Edward Close, Process Systems Enterprise
Markus Gershater, Synthace
Grant Grieve, Fujifilm Diosynth Biotechnologies
Colin Jaques, Lonza Biologics
Cleo Kontoravdi, Imperial College London
Martin Smith, eXmoor pharma concepts
Christopher Spencer, MedImmune

For further information and bookings please contact:
E: mbi-training@ucl.ac.uk
T: +44 (0) 20 7679 9619 l +44 (0) 203 549 5619

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