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Learn how to select the best recovery options for your bioprocess
Understand the principles of all the major recovery operations: centrifugation, membrane systems, filtration, cell disruption, precipitation, flocculation.
This module focuses on the biological product recovery stage and, through a series of lectures and case studies will enable you to:
- Compare these unit operations for suitability within the process
- Determine the most appropriate equipment for separations and specify the right operating conditions
- Learn to use Ultra Scale Down tool for prediction of large scale separation performance
- Understand the interaction among fermentation, recovery and purification and learn the integrated solutions for bioprocess development
This MBI is recommended for:
This module is designed for scientists and engineers involved in design, development and operation of primary recovery steps as well as associated steps in upstream and purification processes.
- Bioprocess developers
- R&D scientists
- Manufacturing technologists
- Manufacturing operational managers
- Module Leader
Andrea Rayat is an Associate Professor in Bioseparations and Downstream Processing at University College London (UCL). She holds Biochemical Engineering and Chemical Engineering degrees from UCL (PhD), TU Delft (MSc, cum laude), and UPLB (BSc). She has also trained at London Business School taking enterprise courses and MBA electives. Prior to her current post, she has had roles outside of academia as a product engineer, product manager and consultant in the biopharma industry.
Her main research aim is to contribute to the understanding of bioseparations of novel, biologically-derived products and to reveal the science and engineering that underpin recovery and purification operation, and their scale-up. Her group achieves this through the design and application of ultra scale-down and millifluidic devices, and other high throughput techniques.
Her work on ultra scale-down as applied to industrial enzyme production has been recognised by the IChemE Global Awards (2020) and by the InnovateUK KTP awards (2021). She actively engages with the scientific community and industry through research collaborations (e.g. Pall (now Cytiva), AstraZeneca, Oxford Biomedica, MHRA) and contributions to scientific meetings (Recovery XIX, ECI Integrated Continuous Biomanufacturing V, HTPD VI, 42nd ISPPP, ECI Single Use Technologies (SUT) VI and as chair in SUT VII in 2025). At UCL, Andrea is also the head of the department teaching committee and is director of the BEng/MEng Biochemical Engineering programs.
- Programme Outline
Day 1
- Introduction to Primary Recovery and Membrane Operations
- Fundamentals of Solid-Liquid (S-L) Separation: Centrifugation and Filtration
- Intracellular Product Release
- Scale-Down of S-L Operations
Day 2
- Case Study 1: Primary Recovery Operations
- Industrial Primary Recovery
- Adsorptive Depth Filtration in Biopharmaceutical Manufacturing
- Impact of Conditioning on Recovery Operations: Precipitation, Crystallisation and Flocculation
- Cell Engineering to Ease Primary Recovery
Day 3
- Case Study 2: Primary Recovery Operations
- Tangential Flow Microfiltration
- Tangential Flow Ultrafiltration
- Ultra Scale-down TFF Mimics
- Spotlight Series: Specialist talk on the state of primary recovery and membrane operations
Day 4
- Simulation Case Study 3 The Role of Microfiltration in Whole Bioprocess Studies
- Rapid Evaluation of Primary Recovery Operations – Delegate Presentations
- Panel with MBI Speakers