Biochemical Engineering


Downstream Processing: From Cell to Column: Integrated Solutions for Rapid Bioprocessing of Biologics

Learn how to select the best recovery options for your bioprocess

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12-15 November 2018

Understand the principles of all the major recovery operations: Centrifugation, Membrane Systems, Filtration, Cell Disruption, Precipitation, FlocculationThis module focuses on the biological product recovery stage and, through a series of lectures, case studies and pilot plant practical sessions, will enable you to:

  • Compare these unit operations for suitability within the process and study them in our unique pilot plant
  •  Determine the most appropriate equipment for separations and specify the right operating conditions
  • Learn to use Ultra Scale Down tool for prediction of large scale separation performance
  • Understand the interaction among fermentation, recovery and purification and learn the integrated solutions for bioprocess development
  • Network with sector leaders and subject matter experts.

Who should attend?

This module is designed for scientists and engineers involved in design, development and operation of primary recovery steps as well as associated steps in upstream and purification processes.

  • Bioprocess developers
  • R&D scientists
  • Manufacturing technologists
  • Manufacturing operational managers


Day 1

  • Centrifugation principles and design
  • Ultra scale-down of solid-liquid separation operations
  • Filtration principles and process performance
  • Microfiltration/Ultrafiltration operational characteristics

Day 2

  • Pilot-plant and ultra scale down studies: Centrifugation
  • Intracellular product release
  • Bioprocess application of centrifuges
  • Ultra scale-down filtration and cell recovery & membrane separation operations

Day 3

  • Pilot-plant studies: Microfiltration
  • From lab scale to manufacturing: micro-filtration technologies for product recovery & purification
  • Ultra scale-down of conditioning and recovery operations - precipitation, crystallisation and flocculation
  • Application of adsorptive depth filtration in biopharmaceutical manufacturing

Day 4

  • Simulation Studies: The role of microfiltration in whole bioprocess studies
  • Cell engineering to ease primary recovery
  • Primary recovery process development with an integrated approach

UCL Experts

Dr Yuhong Zhou - Module Leader
Professor Mike Hoare, UCL
Prof Eli Keshavarz-Moore, UCL
Dr Darren Nesbeth, UCL
Dr Andrea Rayat, UCL
Professor Ajoy Velayudhan, UCL

Previous Expert Speakers

Britta Badertscher, Pall Life Sciences
Colin Burdick, Bioprocess Engineering Services
Dr Klaus Mannweiler, GEA Westfalia Separator Group GmbH
Stuart Rolfe, Merck

A networking dinner will be held on the first evening.

For further information and bookings please contact:
E: mbi-training@ucl.ac.uk
T: +44 (0) 20 7679 9619 l +44 (0) 203 549 5619

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