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Publications and resources
- Can the U.K. Maintain Its Biomanufacturing Empire?
- Centre publications, year 1 (2011-2012)
- Centre publications, year 2 (2012-2013)
- Innovation in biopharmaceutical manufacture workshop (29 November, 2012)
- Challenges in characterising biopharmaceuticals for ease of manufacture (26 July, 2012)
- The launch of the Responsive Biomanufacturing Facility (18 September, 2012)
- RBF launch programme - September 2012
- Making QbD Happen for Biopharmaceuticals - 2nd December 2013
- Vision Supply Chain - 4 Nov 2014
- UCL Creativity at home - Summer 2014
- EPSRC Annual Report 2015
EPSRC Centre New Horizon Research - Tuesday 14 April 2015 (UCL)
This meeting reviewed the “adventurous” research activities that are funded under the Centre’s platform budget and Centre for Doctoral Training. These activities are intended to explore and establish new research directions and to enhance and be complementary to the programme of the two flagship projects. Presentations from feasibility studies funded by the Centre and from CDT projects, including an exhibition of posters covering breadth of Departmental research aligned to the Centre.
- Analytical NMR approaches for process monitoring and product characterisation (Dr Mark Howard, University of Kent)
- Nanofibre Separations – Update (Dr Oliver Hardick, Puridify)
- Formulation design and manufacture of particulate vaccine adjuvants (Elisabeth Kastner, Aston University)
- Optimising separation of complex protein mixtures using chromatography as part of whole bioprocess development (Kosma Jurlewicz, UCL)
- Crystallisation of mAbs for Downstream Purification and Separation (Prof Daryl Williams, Imperial College London)
- An Integrated Scale-Down Platform Process for the Extraction and Recovery of Periplasmically Expressed Fab From E.coli (Asma Ahmed, UCL)
- Investigating the Effects of Flow on Therapeutic Protein Aggregation (Leon Willis, University of Leeds)
- Research challenges for the delivery of vaccines (Prof. Yvonne Perrie, Aston University)
- Predictive Models for Aggregation Propensity/Solubility (Spyros Charonis, University of Manchester)
- Data driven process understanding (Dr. Gunnar Malmquist, GE Healthcare)
'Vaccine process development – better tools for better vaccines' Workshop - 5 November 2014
The challenges for vaccine process development are similar to those for the biopharmaceuticals with one key exception. Vaccines in general do not have platform processes, therefore greater efforts are required in the characterisation of new products and processes. A range of new tools to aid process development for biopharmaceuticals are applicable to the vaccine development process. These focus on speeding the time to market, undertaking process development with minimal amounts of material, applying high throughput methodologies where possible and developing optimal formulations for the final product.
This workshop highlights process development research and development tools applicable to vaccines. The workshop builds new and strengthen existing links between the vaccine research community and the bioprocess research community.
http://www.mrc.ac.uk/funding/science-areas/infections-immunity/science-we-support/
- Ebola Vaccine Development - Gilbert
- Micro-scale Vaccine Development - Mukhopadhyay
- Decisional tools - Farid
- Designer Inorganic Vaccines Ajuvants - Williams
BIA Guest Blog: Improving the biopharma supply chain
http://blog.bioindustry.org/2014/11/13/guest-blog-improving-the-biopharma-supply-chain/