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Biochemical Engineering

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Bioprocess Synthesis and Process Mapping

Course Code
BENGG001
Level MSc
Credits 15 credits
Module Tutor
Dr Dan Bracewell
Assessment
Three-hour Examination (80%)
Coursework (20%)

Aims

To provide the basic principles of bioprocess analysis and design.  This will be achieved by first introducing students to the concept of whole bioprocess sequences and process flow sheets. Mass and energy balance techniques for the key unit operations within the bioprocess sequence will then be considered.

Learning Hours

Includes:

Lectures: 35h
Case studies/practicals: 10h

Syllabus

  • Introduction to Bioprocess Engineering: Overview of Bioprocess Biological Systems and Molecules, Biochemical Reaction Engineering, Bioprocessing
  • Bioprocess Analysis: Engineering Calculations, Processes and Variables, Mass Balance Fundamentals, Reactions and Stoichiometry, Energy Balance Fundamentals
  • Fermentation and Cell Culture: Growth Kinetics I, Growth Kinetics II, Fermentation Mass Balancing I, Fermentation Mass Balancing II, Fermentation Energy Balancing
  • Primary Separation Processes: Introduction to Solid-Liquid Separations, Homogenisation, Centrifugation Case Study I & II, Microfiltration Case Study I & II, Case Study Review
  • Chromatography: Chromatographic Beds and Beads, Modes of Action, Analysis of Chromatography I, Analysis of Chromatography II, Case Study
  • Formulation and Product Dose Forms for biological medicines
  • Bioprocess Design Case Study: biofuels to vaccines