AUTONOMIC NEUROSCIENCE INSTITUTE
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Current Major Research Themes

animated neuron

1) Heat shock protein enhancers and motor neurone disease (with Biorex [Hungary], Linda Greensmith, Institute of Neurology and Robert Brown Jr., Harvard) [See CV 1203, 1205, B1024]

Kalmar, B., Burnstock, G., Vrbova, G. & Greensmith, L. (2002). The effect of neonatal nerve injury on the expression of heat shock proteins in developing rat motoneurones. Journal of Neurotrauma 19, 667-679.

Kalmar, B., Burnstock, G., Vrbová, G., Urbanics, R. & Csermely, P.G.L. (2002). Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats. Exp. Neurol. 176, 87-97.

Kalmar,B., Malcangio,M., Urbanics,R., Csermely,P., McMahon,S.B. and Burnstock,G. (2003). The effect of treatment with a co-inducer of heat shock proteins on sensory fibres of the rat following peripheral nerve injury. Experimental Neurology (in press).

(2)  Purinergic mechanosensory transduction and pain (with Roche Bioscience, Palo Alto) [See CV 1142, 1155, 1167, 1201, C1236, C1237]    

Cockayne, D.A., Hamilton. S.G., Zhu, Q.-M., Dunn, P.M., Zhong, Y., Novakovic, S., Malmberg, A.B., Cain, G., Berson, A., Kassotakis, L., Hedley, L., Lachnit, W.G., Burnstock, G., McMahon, S.B. & Ford, A.P.D.W. (2000) Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407, 1011-1015.

Burnstock, G. (2001). Purine-mediated signalling in pain and visceral perception. Trends Pharmacol. Sci. 22, 182-188.

Vlaskovska, M., Kasakov, L., Rong, W., Bodin, P., Bardini, M., Cockayne, D.A., Ford, A.P.D.W. & Burnstock, G. (2001). P2X3 knockout mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21, 5670-5677.

Rong, W., Spyer, M. & Burnstock, G. (2002). Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J. Physiol. 541, 591-600.

Wynn,G., Rong,W., Xiang,Z. and Burnstock,G. (2003). Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology (in press).

Rong,W., Knight,G., Bei,M., Spyer,K.M. and Burnstock,G. (2003). Activation of ureter nociceptors by exogenous and endogenous ATP. Pain (submitted).    

(3) Purinergic signalling in the airways (with Jean-Pierre Timmermans, Antwerp, and Mike Spyer, Physiology, UCL) [See CV 1221, 1227, C1232, C1243]  

(4) Purinergic signalling and bone formation/resorption [See CV 1158, 1206, 1228]

(5) Purinergic signalling in embryonic development [See CV 1166, 1168, 1185, 1194, 1207, C1227, C1229]

(6) Purinergic signalling in skin, prostate and bladder cancer (with Robert Morgan, Urology, Royal Free, and Malcolm Rustin, Dermatology, Royal Free) [See CV 1226, B1011, B1017, C1216, C1217]

(7) Purinergic signalling in the kidney (with Robert Unwin, Nephrology & Physiology, UCL)
[See CV 1171, C1061, C1146]

(8) Chairman IUPHAR Committee on Nucleotide P2 Receptors [See CV 1146, 1215, 1220, 1230]

 

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