Centre for Anaesthesia Critical Care & Pain Medicine


Dr David Brealey PhD MRCP FRCA

Lead for Clinical Trials, Critical Care
Consultant in Anaesthesia  and Critical Care, UCLH


Mechanisms underlying postoperative organ dysfunction and sepsis

Mitochondrial Dysfunction

Statin therapy

Selected Publications

.Outcome in Poor Grade Subarachnoid Hemorrhage Patients Treated with Acute Endovascular Coiling of Aneurysms and Aggressive Intensive Care.Taylor CJ, Robertson F, Brealey D, O'shea F, Stephen T, Brew S, Grieve JP, Smith M, Appleby I.Neurocrit Care. 2010 May 13. [Epub ahead of print]

Hyperglycemia in critical illness: a review.

Brealey D, Singer M.

J Diabetes Sci Technol. 2009 Nov 1;3(6):1250-60. :

hondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components.

Svistunenko DA, Davies N, Brealey D, Singer M, Cooper CE.

Biochim Biophys Acta. 2006 Apr;1757(4):262-72. Epub 2006

Human septic myopathy: induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway.

Rabuel C, Renaud E, Brealey D, Ratajczak P, Damy T, Alves A, Habib A, Singer M, Payen D, Mebazaa A.

Anesthesiology. 2004 Sep;101(3):583-90.

Association between mitochondrial dysfunction and severity and outcome of septic shock.

Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M.

Lancet. 2002 Jul 20;360(9328):219-23.


Prof Mervyn Singer

Clinical Trials in Critical Care at UCLH

Address Anaesthetics Department
Podium 3, Maple Link corridor
University College Hospital
235 Euston Road
Contact d.brealey[at]ucl.ac.uk