## Tom Wyatt

### CoMPLEX Mres/PhD UCL

thomas.wyatt.11@ucl.ac.uk

I grew up on Hillfield Road in Comberton, playing for Comberton Crusaders and also spending time in Hardwick, Toft and Bourn. I later studied Physics at university for four years. After that, in September 2011, I began the CoMPLEX MRes/PhD programme at UCL hoping to find an interesting area of biology to work in.

### MRes work

This year I've completed three six week long projects on a range of topics and I'm currently doing a 3 month long summer project.

Project 1: The feasibility of 3D interferometer microscopy pdf
Interferometers are instruments which use light to measure distances on tiny scales (1000's of times smaller than the wavelength of the light used). The goal of this project was to find out if a 3D arrangement of interferometers could be used to create a microscope with greater resolution than conventional microscopes. I began to derive theoretically how the microscope would respond to simple objects. Unfortunately, I didn't get far enough in the calculations to get an idea of the resolution of the microscope.

My supervisors for this project were Phil Jones and Geraint Thomas.

Project 2: Segmenting electron microscope images of the brain pdf
In this project I used random forests and BIFs to segment electron microscope images of the brain. I found this method was an improvement on other BIF based methods.

My supervisors for this project were Lewis Griffin and Arnd Roth.

Project 3: Closed walks in biological networks pdf
Biological networks represent parts of biological systems as 'nodes' and interactions (of some kind) between these components as 'edges' which connect these nodes. A closed walk on such a network is a sequence of steps between connected nodes, which starts and ends on the same node. It is easy to count how many closed walks of a given length could be taken from each node, call this information the network's 'walk matrix'. In the purely mathematical phase of this project I found some networks which were uniquely defined by their walk matrix. I then showed how information from the walk matrix could be used in biological networks to distinguish better between two types of nodes called 'party hubs' and 'date hubs'.

My supervisors for this project were Simone Severini and Andrew Teschendorff.

Summer Project: Epithelial mechanics
Details to come soon...

My supervisors for this project are Buzz Baum and Mark Miodownik.

Finally, I also made a poster with Chris Banerji.

I also enjoy photography, spirography and steganography. Here is an example of my work in each of these fields.