Autosomal Dominant

This looks right. The affected children both have the same affected father. Their two sibs are not affected (so it's a 50:50 pattern of inheritance), and their father has an affected sister. There is male to male transmission and there are affected females so it does not look like an X linked condition.

A two generation family with just two affected members in each generation is not enough to track down a mutant gene solely on the basis of its pattern of inheritance.

	So what is the easiest thing which should you do next?
	Publish at this stage in the Indian Journal of Human Genetics without doing anything else! They will surely accept a small paper describing this fascinating new syndome.
	Track down more family members – maybe the family extends a long way and this one family will prove to be big enough on its own to provide the linkage information which will locate the gene.
	Invite Dr. Wolfe back at UCL to join your study, he can do the hard bench work to identify the gene while you maybe find a few more family members and bask in the glory of an eye syndrome named after you.

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