This looks right. The affected children both have the same affected father. Their two sibs are not affected (so it's a 50:50 pattern of inheritance), and their father has an affected sister. There is male to male transmission and there are affected females so it does not look like an X linked condition.
A two generation family with just two affected members in each generation is not enough to track down a mutant gene solely on the basis of its pattern of inheritance.
So what is the easiest thing which should you do next?
|Publish at this stage in the Indian Journal of Human Genetics without doing anything else! They will surely accept a small paper describing this fascinating new syndome.|
|Track down more family members – maybe the family extends a long way and this one family will prove to be big enough on its own to provide the linkage information which will locate the gene.|
|Invite Dr. Wolfe back at UCL to join your study, he can do the hard bench work to identify the gene while you maybe find a few more family members and bask in the glory of an eye syndrome named after you.|
|Back to the beginning of the exercise.|
|Back to the beginning of the session|