Pharmacogenetics – inherited variability in drug response
Adverse drug reactions are the fourth leading cause of death in the developed world. Many adverse drug reactions occur at standard manufacturer doses.
The lecture will introduce:
e.g. the Cytochrome P450 (CYP) family. CYP2D6 metabolizes 25% of all therapeutic drugs. Three CYP2D6 phenotypes are observed: poor metabolisers, extensive metabolisers and ultra rapid metabolisers. The consequences of each phenotype for drug therapy will be described.
e.g. N-acetyl transferase family. NAT2 acetylates a number of drugs thereby increasing their hydrophilicity and aiding the excretion of the drug through the bile and urine. Rapid and slow acetylators have been identified.
Introduction to Drug Metabolism – G. Gordon Gibson and Paul Skett – Blackie Academic & Professional
Emery’s Elements of Medical Genetics (11th Edtn) Mueller, R.F. and Young, I.D.
Meyer, U.A. (2000) Pharmacogenetics and adverse drug reactions The Lancet 356:1667-1671.
Roses, A.D. (2000) Pharmacogenetics and the practice of medicine Nature 405:857- 865.
Roses, A.D. (2001) Pharmacogenetics Human Molecular Genetics 10: 2261-2267