TARGIT
Targit trial – Targeted Intraoperative Radiotherapy for Breast Cancer
The TARGIT trial
2010 NEWS FLASH: TARGIT-A trial results at ASCO and in the Lancet
The results of the TARGIT-A trial published in The Lancet Online first
Oral presentation at the TARGIT Symposium, ASCO, Chicago, USA
7 June 2010
Poster Discussion, ASCO, Chicago, USA
Click here to read a brief description of the TARGIT-A trial and its results
In the randomised TARGIT-A trial, two policies of local radiation treatment after breast cancer surgery are compared:
Breast cancer patient (>=45 years) suitable for breast conserving surgery
Eligible patients can be recruited at two stages of their treatment in the pragmatic Targit trial:
Before the primary surgery
If a patient is to have her primary breast cancer operation at a hospital where intraoperative radiotherapy ( radiation treatment with the TARGIT approach) can be given, then randomisation in the Targit trial can be done before surgery and intraoperative radiation treatment can be given at the same time as the lumpectomy for breast cancer, if they draw the TARGIT treatment. If at the postoperative pathology review, it is felt that they have a particularly high risk of local recurrence especially in other quadrants (e.g., EIC, extensive LVI or nodal metastases, etc) then external beam radiotherapy can be added and the patient will remain in the trial.
Click to see the detail figure
After the primary surgery
If primary surgery is performed elsewhere, or if it is logistically easier, randomisation in the Targit trial can be performed after the primary surgery (lumpectomy or wide local excision) and pateints can have a single session targeted intraoperative radiotherapy as a day-case operation . If a patient draws the EBRT group, then external beam radiotherapy can be administered at their usual hospital (we will have recorded the exact schedule).
Click to see the detail figure
The TARGIT technique uses the Intrabeam device for delivering precise and timely dose of intraoperative radiotherapy accurately to the tumour bed. This device was developed by an collaborative effort between University College London and the industry. It has had extensive experience since its first use in July 1998.
Visit: The TARGIT trial Blog
This page lists the original articles about the TARGIT treatment, the Targit trial, and evolution of the Targit approach.
Targeted intraoperative radiotherapy Literature
[NOTE: these papers can be downloaded strictly for personal use only. This site is maintained by Dr Jayant S Vaidya ]
Pathological and biological rationale of
partial breast irradiation (PBI) and the basis of the Targit Trial
1995 Hongkong International Cancer Congress
1996 British Journal of Cancer
Could MRI be useful to select patients for breast conserving surgery?
The Core trial Protocol of the Targit Trial
The UK Pilot Study of intraoperative radiation therapy:
the first full paper about Targit
The surgical technique of targeted intraoperative radiotherapy
(TARGIT) for early breast cancer treatment
as used in the Targit trial
2002 European Journal of Surgical Oncology
A possible one-stop out patient treatment for small breast cancers
PhD Thesis of Jayant S Vaidya
2002 University College London PhD Thesis
Some publicity
2003 San Antonio Breast Cancer Symposium
30-minute invited presentation about the Targit trial
Poster discussion about cosmetic results of
the (Targit) intraoperative radiation therapy boost cases
Acute and Late Toxicity data about the Targit approach.
2004 ANZ Journal of Surgical Oncology
2006 Int J Rad Oncol Biol Phys
Reviews, Editorial, Viewpoint
2004 British Journal of Radiology
2005 Seminas in Radiation Oncology
2007 Nature Clinical Practice Oncology
2008 Annals of New York Academy of Sciences
Book Chapters
2003 Recent Advances in Surgery
2006 Accelerated Partial Breast Irradiation (1st Edition)
2009 Accelerated Partial Breast Irradiation (2nd Edition)
Radiobiology of Targeted intraoperation radiation therapy (TARGIT)
Mathematical Modelling of breast cancer growth, recurrence
and intra-operative radiotherapy (IORT)
2005 Cancer Research UK Award Poster
2006 Journal of Theoretical Biology
2007 Journal of Theoretical Biology
Targit under Local Anaesthetic
2006 World Journal of Surgical Oncology
Targit boost :- resuts in a very low recurrence
2006 International Journal or Radiation Oncology Biology Physics
2008 American Society of Clinical Oncology (ASCO)
5-yr actuarial = 1.52%
Novel effects of TARGIT on tumour micro-environment
2009 International Journal of Radiation Oncology Biology Physics
Patient Information about Targit as a Single Procedure
Patient Information about Targit as a Subsequent Procedure
TARGIT is an elegant approach of partial breast irradiation (PBI) for breast cancer. Please scroll down for the literature about the TARGIT approach and the TARGIT trial