Targit trial – Targeted Intraoperative Radiotherapy for Breast Cancer

The TARGIT-A trial is
-for patients who are 45 years or older and is designed to test if a risk adjusted approach using a single dose of IORT using TARGIT gives similar results as the usual radiotherapy over several weeks.
This trial has completed recruitment. The first results of the TARGIT-A trial were presented in ASCO 2010 and published in the Lancet in July 2010. The updated results after trial closure (n=3451) were presented in San Antonio Breast Cancer Symposium on 6 December 2012.

The TARGIT-B trial is
for patients who are younger than 45 years, or have a higher risk of cancer recurrence and is designed to test if giving an intraoperative tumour bed boost using TARGIT is superior to the usual externally given tumour bed boost, both in addition to whole breast radiotherapy. This trial starts recruitment in Spring 2013

Both these trials are for patients who have a breast conserving surgery i.e., wide local excision, or lumpectomy. Breast cancer patients who need a mastectomy are not currently suitable for TARGIT.

Recent presentations about TARGIT at international scientific meetings and conference

March 2013 St Gallen Breast Cancer Conference: Two new posters:

Omitting whole breast radiotherapy does not increase axillary recurrence- data from TARGIT-A trial

Fewer non-breast cancer deaths in TARGIT-A trial:systemic benefit of TARGIT or lack of EBRT toxicity

6 December 2012 (General session 4)
Late breaking plenary presentation at the 2012 San Antonio Breast Cancer Symposium: TARGIT-A trial: Updated results and first analysis of survival
Click on Thursday, 6 December - then General session 4 - 2nd presentation

IORT for Breast Cancer TARGIT-A trial 2012 update (for those with Flash)

Intraoperative radiotherapy vs. External beam radiotherapy - ASCO Post (15 Feb 2013)
If you cannot access this on the original site the single page can be downloaded here TARGIT-A trial - risk adapted IORT vs EBRT

13 September 2012
TARGIT-A and TARGIT-B trials: Plenary presentation at the ASCO Breast Cancer Symposium, San Francisco

15 March 2012
The TARGIT trials: Audience poll after TARGIT presentation at the Miami Breast Cancer Conference, USA.

7 Nov 2011
TARGIT-A trial results: plenary lecture at the BASO-ACS Annual meeting, Royal College of Surgeons of England, London, UK

19 March 2011
At the 12th International St.Gallen Breast Cancer Conference, St.Gallen, Switzerland, the consensus panel of 52 experts at the Consensus session on the last day of the conference voted in favour of using intraoperative radiotherapy.

September 2010
A description of the TARGIT-A trial in an interview with eCancer TV at the ESSO meeting Bordeaux

5 June 2010
The results of the TARGIT-A trial published in The Lancet Online first
BBC news
A brief description of the TARGIT-A trial and its results: Click to read

6 June 2010
Oral presentation at the TARGIT Symposium, ASCO, Chicago, USA

The TARGIT - A trial

In the randomised TARGIT-A trial, two policies of local radiation treatment after breast cancer surgery are compared:


Breast cancer patient (>=45 years) suitable for breast conserving surgery

TARGIT trial core schema

The TARGIT technique uses the Intrabeam device for delivering precise and timely dose of intraoperative radiotherapy accurately to the tumour bed. This device was developed by an collaborative effort between University College London and the industry. It has had extensive experience since its first use on 2 July 1998.

Visit: The TARGIT trial Blog

This page lists the original articles about the TARGIT treatment, the Targit trial, and evolution of the Targit approach.

Targeted intraoperative radiotherapy Literature

[NOTE: these papers can be downloaded strictly for personal use only. This site is maintained by Dr Jayant S Vaidya ]

            Pathological and biological rationale of

           partial breast irradiation (PBI) and the basis of the Targit Trial

1995    Hongkong International Cancer Congress

1996    British Journal of Cancer

1997    The Lancet 


            Could MRI be useful to select patients for breast conserving surgery?

1998    The Lancet (1)

1998    The Lancet (2)  


           The Core trial Protocol of the Targit Trial

1999    The Lancet

            The UK Pilot Study of intraoperative radiation therapy:

            the first full paper about Targit

2001    Annals of Oncology


            The surgical technique of targeted intraoperative radiotherapy

            (TARGIT) for early breast cancer treatment

            as used in the Targit trial

2002    European Journal of Surgical Oncology

2002    Surgical Technique Video 

           A possible one-stop out patient treatment for small breast cancers

2002    The Lancet


            PhD Thesis of Jayant S Vaidya

2002    University College London PhD Thesis


           Some publicity

2000    BBC Tomorrow’s World

2001     Lancet Oncology News

2002    Time Magazine

2003    Reader’s Digest

2006    Reader’s Digest


            2003 San Antonio Breast Cancer Symposium

              30-minute invited presentation about the Targit trial

2003    Powerpoint

2003    Flash (SABCS Website)

            Poster discussion about cosmetic results of

            the (Targit) intraoperative radiation therapy boost cases

2003    Cosmetic Outcome


            Acute and Late Toxicity data about the Targit approach.

2004    ANZ Journal of Surgical Oncology

2005    Oncologie

2005    Tumori

2006    Int J Rad Oncol Biol Phys 


            Reviews, Editorial, Viewpoint

2004    Lancet Oncology

2004    British Journal of Radiology

2005    Seminas in Radiation Oncology

2006    Clinical Oncology

2006    The Breast

2007    Nature Clinical Practice Oncology

2008    Annals of New York Academy of Sciences


            Book Chapters  

2003    Recent Advances in Surgery

2006    Accelerated Partial Breast Irradiation (1st Edition)

2009    Accelerated Partial Breast Irradiation (2nd Edition)


            Radiobiology of Targeted intraoperation radiation therapy (TARGIT) 

            Mathematical Modelling of breast cancer growth, recurrence

            and intra-operative radiotherapy (IORT) 

2005    Radiation Research 

2005    Cancer Research UK Award Poster

2006    Journal of Theoretical Biology

2007    Journal of Theoretical Biology

            Targit under Local Anaesthetic 

2006    World Journal of Surgical Oncology


            Targit boost :- resuts in a very low recurrence

2006    International Journal or Radiation Oncology Biology Physics

2008    American Society of Clinical Oncology (ASCO)

             5-yr actuarial = 1.52% 

            Novel effects of TARGIT on tumour micro-environment

2008    Clinical Cancer Research

2009    International Journal of Radiation Oncology Biology Physics



The Targit trial Protocol


Patient Information about Targit as a  Single Procedure

Patient Information about Targit as a Subsequent Procedure



Locations of visitors to this page


TARGIT is an elegant approach of partial breast irradiation (PBI) for breast cancer. Please scroll down for the literature about the TARGIT approach and the TARGIT trial