Mathematical Modelling of cancer and Statistical methods

Omission of Nitrous oxide during anaesthesia reduces the incidence of post-operative nausea and vomiting: A meta-analysis

J Divetia, JS Vaidya, RA Badwe, R Hawaldar:

Anesthesiol. Nov 1996;85(5):1055-62 PubMed, Abstract

(abstract) Importance of non-linear mathematical modelling in hypothesis generation in cancer with special reference to breast cancer

Jayant S Vaidya, Michael Baum.

Clinical and Experimental Metastasis Jan 1997; 15(1):67

Fraction of Normal remaining life: a new method of expressing survival in cancer

JS Vaidya, I Mittra.

BMJ 7 Jun 1997; 314:1682-1684.

Quoted in Cancer Topics, Oct-Nov 1997;10(8):5,

Responses in BMJ 22 Nov 1997; 1375-76. WWW, PDF       

A novel way to answer ‘what is my chance of cure?’

(Letter) The Psion of times

Jayant S Vaidya, M Baum.

The Lancet  13 Dec 1997;350:1784. PDF

We used the Psion handheld  to compute breast cancer risk due to family history in the clinic

(Letter) The new method of expressing survival in cancer is popular

Jayant S Vaidya, Indraneel Mittra.

BMJ 4 April 1998;316:1092 , HTML,

Patients appear to prefer their prognosis to be given as the chance of surviving their normal life span or its proportion.

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Unopposed oestrogen and breast cancer survival: a meta-analysis

Badwe RA, Bhansali MS, JS Vaidya

The Breast. April 1998;7(2):66-71.Abstract 

Meta-analyses revealed a significantly better survival in premenopausal vs postmenopausal patients (22 studies, OR 0.76) in patients who were operated in the luteal vs follicular phase of the menstrual cycle (28 studies, OR 0.87) and in postmenopausal women who were not obese vs obese (18 studies, OR 0.64). Unopposed oestrogen at the time of surgery may have a deleterious effect on survival in women of all ages.

Does breast cancer exist in a state of chaos? 

M Baum, MAJ Chaplain, ARA Anderson, M Douek, JS Vaidya.

Eur J Cancer, Jun 1999;35(6):886-891. PDF, 30. Anderson ARA, Chaplain MAJ.

A mathematical model based on three coupled non-linear partial differential equations could describe vascular growth in a breast tumour- such models  be used in pre-trial settings to test new therapies

Functional maps of metastases from breast cancers: proof of the principle that multidimensional scaling can summarize disease progression

Lincoln C. Gray, Jayant S Vaidya, Michael Baum, Rajendra A. Badwe, Indraneel Mittra, Tariq Siddiqui, Dorothea Wiarda,

World Journal of Surgery, Jul 2004;28(7): 646–651 PDF

A mathematical model for the effect of false negative rate of sentinel node biopsy on breast cancer mortality – a tool for everyday use.

Vaidya JS, Dewar JA, Brown DC, Thompson AM

Breast Cancer Research 15 August 2005, 7:225-227 WWW PDF

V-index: A fairer index to quantify an individual 's research output capacity

Jayant S Vaidya

BMJ 6 Dec 2005 http://bmj.com/cgi/eletters/331/7528/1339-c#123188

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Mathematical modelling of radiotherapy strategies for early breast cancer

Enderling H, Anderson ARA, Chaplain MAJ, Munro AJ, Vaidya JS*

J Theor Biol 2006 Jul 7;241(1):158-71. (Epub 28 Dec 2005)  DOI: 10.1016/j.jtbi.2005.11.015 PDF