On the Origin and Nature of Cancer

(Letter) Haematogenous dissemination of prostate epithelial cells during surgery and Does surgery disseminate or accelerate cancer

Rajendra A Badwe, Jayant S Vaidya

The Lancet: 3 February 1996; 347:325-326. PDF Printer’s correction 1996;347:842.

(Letter) The concept of scientific holism

J S Vaidya

Natl Med J Ind. Dec 1996; 9(6): 299-300

(abstract) Importance of non-linear mathematical modelling in hypothesis generation in cancer with special reference to breast cancer

Jayant S Vaidya, Michael Baum.

Clinical and Experimental Metastasis Jan 1997; 15(1):67

(Letter) Molecular staging of cancer.

M Baum, JS Vaidya.

The Lancet 27 Sept 1997; 350(9082):962.

(abstract) Local Recurrence of Breast Cancer: New concepts about its biology and clinical relevance

J S Vaidya, I Mittra, M Baum,

Br J Cancer July 1997 (76:suppl-1)(O03):17

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Can MRI be used to elucidate the natural history of breast cancer multicentricity?

Michael Douek, Jayant S Vaidya, Sunil R Lakhani, Margaret Hall-Craggs, Michael Baum, Irving Taylor.

The Lancet 14 March 1998; 351:801-802. , HTML, PDF,  

MRI is sensitive enough to detect otherwise occult cancer foci but probably cannot identify potentially dangerous ones

Unopposed oestrogen and breast cancer survival:

Badwe RA, Bhansali MS, JS Vaidya

The Breast. April 1998;7(2):66-71.Abstract 

Meta-analyses revealed a significantly better survival in premenopausal vs postmenopausal patients (22 studies, OR 0.76) in patients who were operated in the luteal vs follicular phase of the menstrual cycle (28 studies, OR 0.87) and in postmenopausal women who were not obese vs obese (18 studies, OR 0.64). Unopposed oestrogen at the time of surgery may have a deleterious effect on survival in women of all ages.

(Letter) Spiral CT  and Lung cancer biology.

Jayant S Vaidya, Michael Baum,

The Lancet 18 July 1998; 352:236 WWW, HTML, PDF,

Spiral CT perhaps detects cancers that would never otherwise become symptomatic-also, normal homeostasis may involve anti-angiogenic processes much more widely.

(Letter) Magnetic resonance imaging and breast cancer multicentricity.

M Douek, JS Vaidya,  I Taylor, M Baum

The Lancet 22 August 1998.352:652-653  , HTML, PDF, PDF

 Does breast cancer exist in a state of chaos? 

M Baum, MAJ Chaplain, ARA Anderson, M Douek, JS Vaidya.

Eur J Cancer, Jun 1999;35(6):886-891. PDF, 30. Anderson ARA, Chaplain MAJ.

A mathematical model based on three coupled non-linear partial differential equations could describe vascular growth in a breast tumour- such models  be used in pre-trial settings to test new therapies

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(Letter) "Early Cancer" vs. "Dormant Cancer" and the potential hazards of the rush to surgery.

Jayant S Vaidya, Michael Baum

BMJ 1 Oct 1999  http://www.bmj.com/cgi/eletters/319/7210/642#EL4  WWW, HTML

(Letter) Management of early-onset breast cancer and BRCA1 or BRCA2 status.

J S Vaidya, M Baum.

The Lancet 24 Aug 2002;360:640. HTML, PDF 

Hafty and colleagues’ data means that women <42 yrs have a high risk of  local recurrence risk (21% ipsilateral breast and 9% contralateral over 12 yrs); 20% will harbour a deleterious mutation of BRCA genes confering risks of 49% and 42%, respectively.

Understanding and Management of Breast Cancer:QuoVadis

Jayant S Vaidya, Natl Med J India Sep-Oct 2002;15(5):252-6. PDF

Functional maps of metastases from breast cancers: proof of the principle that multidimensional scaling can summarize disease progression

Lincoln C. Gray, Jayant S Vaidya, Michael Baum, Rajendra A. Badwe, Indraneel Mittra, Tariq Siddiqui, Dorothea Wiarda,

World Journal of Surgery, Jul 2004;28(7): 646–651 PDF

A mathematical model for the effect of false negative rate of sentinel node biopsy on breast cancer mortality – a tool for everyday use.

Vaidya JS, Dewar JA, Brown DC, Thompson AM

Breast Cancer Research 15 August 2005, 7:225-227 WWW PDF

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A mathematical model for therapeutic effect of different radiotherapy strategies

Henderling H*, Chaplain MAJ, Anderson S, Munro AJ, Vaidya JS*

J Theor Biol  2006 Jul 7;241(1):158-71. (Epub 28 Dec 2005) DOI: 10.1016/j.jtbi.2005.11.015 PDF

An alternative model of cancer cell growth and metastasis.
Jayant S Vaidya.
Int J Surgery. 2007;5(2):73-75 (Epub 14 Jul 2006) http://dx.doi.org/10.1016/j.ijsu.2006.06.003 PDF