Breast Cancer    

 

Expertmapper (www.expertmapper.com) objectively ranks medical experts.

Here are those for breast cancer surgery and breast cancer radiotherapy  in the UK

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A new bedside test to assess feasibility of primary closure after mastectomy for locally advanced breast cancer.

Jayant S Vaidya

J Surg Oncol. Dec 1995; 60(4):286 PDF.

A simple way to test whether primary closure will be possible after mastectomy for a large cancer.

 

(Letter) Does surgery disseminate or accelerate cancer?

Rajendra A Badwe, Jayant S Vaidya

The Lancet: 3 February 1996; 347:325-326. PDF Printer’s correction 1996;347:842.

 

Role of Ultrasonography to detect metastatic nodes in Breast Cancer

JS Vaidya, JJ Vyas, KC Khandelwal, MH Thakur, I Mittra.:

Eur J Surg Oncol. Apr 1996; 22(2): 140-143.PubMed, Abstract, PDF

In women below 45 years, clinical examination+ Ultrasonography (non-doppler 7.5MHz) has a sensitivity of 91% in detecting metastatic lymph nodes.

 

Multicentricity of breast cancer: Whole organ analysis and clinical implications

JS Vaidya, JJ Vyas, RF Chinoy, NH Merchant, OP Sharma, I Mittra.

Br J  Cancer.  Sept 1996; 74 (5): 820-824.

Commentary in The Lancet  9 Nov 1996; 348: 1257-1258 PubMed, Abstract, PDF

63% of mastectomy specimens contain other microscopic cancers and when analysed in 3-D, their spatial distribution is throughout the breast- 80% of them are in quadrants other than the primary cancer

 

(Letter) Should breast reduction surgery be rationed? Only a third of women completed both questionnaires

JS Vaidya, N Sacks.

BMJ. 7 Dec1996;313:1278-79, HTML,

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(Letter) Multicentricity and recurrence of breast cancer 

M Baum, JS Vaidya, I Mittra,

The Lancet. 18 Jan 1997; 349: 208. PDF

 

(abstract) Importance of non-linear mathematical modelling in hypothesis generation in cancer with special reference to breast cancer

Jayant S Vaidya, Michael Baum.

Clinical and Experimental Metastasis Jan 1997; 15(1):67

 

Tamoxifen breast cancer prevention: the UK trials.

M Baum. JS Vaidya.

Forum: Trends in Clin  Exper Med 1997; 7.1 (suppl 2):107-11.

 

(abstract) Local Recurrence of Breast Cancer: New concepts about its biology and clinical relevance

J S Vaidya, I Mittra, M Baum,

Br J Cancer July 1997 (76:suppl-1)(O03):17

 

Fraction of Normal remaining life: a new method of expressing survival in cancer

JS Vaidya, I Mittra.

BMJ 7 Jun 1997; 314:1682-1684.

Quoted in Cancer Topics, Oct-Nov 1997;10(8):5,

Responses in BMJ 22 Nov 1997; 1375-76. WWW, PDF       

A novel way to answer ‘what is my chance of cure?’

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(Letter) Benefits and risks of screening mammography in women with BRCA1 and BRCA2 mutations.

Jayant S Vaidya, Michael Baum 

JAMA, 23-30 Jul 1997; 278(4):290 HTML,

BRCA genes are involved  in DNA repair so a person lacking functional BRCA genes would be exquisitely sensitive to even small amounts of ionizing radiation. Is mammography safe in these women?

 

Prediction of nipple-areola involvement in breast cancer:

JJ Vyas, Chinoy RF,  JS Vaidya.

Eur J Surg Oncol. Feb 1998; 24:15-16. PubMed, Abstract,

Of 140 patients undergoing mastectomy 22 had nipple involvement and in all these cases, the tumour was within 2.5 cm of the areola- so nipple-areola preserved if the tumour is beyond 2.5cm of the areola

 

Can MRI be used to elucidate the natural history of breast cancer multicentricity?

Michael Douek, Jayant S Vaidya, Sunil R Lakhani, Margaret Hall-Craggs, Michael Baum, Irving Taylor.

The Lancet 14 March 1998; 351:801-802. , HTML, PDF,  

MRI is sensitive enough to detect otherwise occult cancer foci but probably cannot identify potentially dangerous ones

 

(Letter) The new method of expressing survival in cancer is popular

Jayant S Vaidya, Indraneel Mittra.

BMJ 4 April 1998;316:1092 , HTML,

Patients appear to prefer their prognosis to be given as the chance of surviving their normal life span or its proportion.

 

Preoperative MRI does not influence the amount of breast tissue excised in conservative cancer surgery 

M Douek, JS Vaidya, T Davidson, SR Lakhani, MA Hall-Craggs, M Baum, I Taylor.

Eur J Cancer 1998;34(S5): p.189

 

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Women prefer breast cancer prognosis expressed as chance of cure to 10-year survival.

JS Vaidya, M Douek, VG Lokare, J Secker-Walker, L Fallowfield, I Taylor, M Baum.

Eur J Cancer 1998;34(suppl 5):S65 PDF

 

Communication of breast cancer prognosis: Women wish to know their chance of cure.

JS Vaidya, M Douek, V G Lokare, J Secker-Walker, L Fallowfield, I Taylor, M Baum.

Eur J Surg Oncol 1998;24(4):345

 

Unopposed oestrogen and breast cancer survival: a meta-analysis

Badwe RA, Bhansali MS, JS Vaidya

The Breast. April 1998;7(2):66-71.Abstract 

Meta-analyses revealed a significantly better survival in premenopausal vs postmenopausal patients (22 studies, OR 0.76) in patients who were operated in the luteal vs follicular phase of the menstrual cycle (28 studies, OR 0.87) and in postmenopausal women who were not obese vs obese (18 studies, OR 0.64). Unopposed oestrogen at the time of surgery may have a deleterious effect on survival in women of all ages.

 

(Letter) Magnetic resonance imaging and breast cancer multicentricity.

M Douek, JS Vaidya,  I Taylor, M Baum

The Lancet 22 August 1998.352:652-653  , HTML, PDF,

 

Clinical and Biological Implications of the Milan breast conservation trials.

Jayant S Vaidya, Michael Baum [Editorial].

Eur J Cancer  August 1998; 34(8):1143-1144. PDF,.

With more extensive the surgery, local recurrence, but not survival, is slightly reduced but perhaps at a great cosmetic cost.

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The price of autonomy.

M Baum, JS Vaidya,

Health Expectations May 1999;2(2):78-81. PubMed, Abstract

We estimate that the price of patient autonomy is 2500 lives over a 10-year period in the United Kingdom alone- and patients and ethicists should be aware of this.

 

(Letter) Randomised trials are not unethical.

Jayant S Vaidya, Michael Baum,

The Lancet 15 May 1999;353:1714., PDF

 

 Does breast cancer exist in a state of chaos? 

M Baum, MAJ Chaplain, ARA Anderson, M Douek, JS Vaidya.

Eur J Cancer, Jun 1999;35(6):886-891. PDF, 30. Anderson ARA, Chaplain MAJ.

A mathematical model based on three coupled non-linear partial differential equations could describe vascular growth in a breast tumour- such models  be used in pre-trial settings to test new therapies

 

(Letter) "Early Cancer" vs. "Dormant Cancer" and the potential hazards of the rush to surgery.

Jayant S Vaidya, Michael Baum

BMJ 1 Oct 1999  http://www.bmj.com/cgi/eletters/319/7210/642#EL4  WWW, HTML

 

Targeted Intraoperative Radiotherapy (TARGIT): an innovative method of treatment for early breast cancer.

JS Vaidya, M Baum, JS Tobias, D D'Souza, S Morgan, M Metaxas, S Naidu , K Harte, Alan Sliski, E Thomson

Annals of Oncology   August  2001:12:1075-1080. PDF.

It is feasible and safe to deliver intraoperative radiotherapy for breast cancer using Intrabeam and we have started a randomised trial to test whether this could replace the usual 6-wk postoperative course.

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Percutaneous Minimally invasive stereotactic Primary Radiotherapy

Jayant S Vaidya , Margaret Hall-Craggs, Michael Baum, Jeffrey S Tobias, Mary Falzon, Derek P D’Souza, Steve Morgan

Lancet Oncology  2002;April 3(4):252-253 PDF       

 

High dose of radiation using the PRS400 delivered to the centre of breast cancer on a stereotactic prone-table as the primary treatment eradicated the tumour.

Minimally invasive therapy for the treatment of breast tumours

Margaret A. Hall-Craggs and Jayant S. Vaidya

European Journal of Radiology, Volume 42, Issue 1, April 2002, Pages 52-57 PDF

 

The novel technique of delivering targeted Intraoperative radiotherapy (TARGIT).

JS Vaidya, M Baum, JS Tobias, D D’Souza, S Morgan.

Eur J Surg Oncol  June 2002; 28: 447-454 PDF

The detail operative technique of giving Targit - including the 8-min operative video.

 

Colonic Metastasis from breast cancer- a case report and some questions.

JS Vaidya, H Mukhtar, Richard Bryan.

Eur J Surg Oncol June 2002; 28: 462-463 PDF

 

(Letter) Management of early-onset breast cancer and BRCA1 or BRCA2 status.

J S Vaidya, M Baum.

The Lancet 24 Aug 2002;360:640. HTML, PDF 

Hafty and colleagues’ data means that women <42 yrs have a high risk of  local recurrence risk (21% ipsilateral breast and 9% contralateral over 12 yrs); 20% will harbour a deleterious mutation of BRCA genes confering risks of 49% and 42%, respectively.

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Understanding and Management of Breast Cancer:QuoVadis

Jayant S Vaidya, Natl Med J India Sep-Oct 2002;15(5):252-6. PDF

 

(Letter) Screening for breast cancer

Jayant S Vaidya New Engl J Med  7 August, 2003;349:6:611 

This review overestimates the effect of screening- it is actually 5 per 10,000 women screened and not 5 per 1000. WWW, WWWPDF, PDF

 

(Letter) Screening for breast cancer with mammography.

JS Vaidya

The Lancet 22/29 Dec 2001;358:2166, WWW, HTML, PDF

If we believe Olsen and Gřtzsche, failure of screening to save lives is a sad fact that we might need to accept, and a plausible explanation may make it easier. Absence of benefit from screening may actually point to a very fundamental hidden biological clue - think away from the dogma of killing ‘early cancer’ and start thinking about living with dormant cancer.

 

(Abstract) Cosmetic outcome after targeted intraoperative radiotherapy (targit) for early breast cancer.

Vaidya JS, Wilson A, Houghton J, Tobias JS, Joseph D, Wenz F, Hilaris B, Massarut S, Keshtgar M, Sainsbury R, Taylor I, D’Souza D, Saunders C, Corica T, Ezio C, Mauro A, Baum M

Br C Res Treat 2003:82;Suppl 1:S180 (#1039) WWW, PDF

 

Orientation of a breast specimen with radio-opaque thread- a novel solution 

Jayant S Vaidya, Alan Wilson, R Choudhary.

Eur J Surg Oncol Mar 2004;30:460-461 PDF

 

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Intraoperative radiotherapy for breast cancer.

Jayant S Vaidya, Jeffrey S Tobias, Michael Baum, Mohammed Keshtgar, David Joseph, Frederik Wenz, Joan Houghton, Christobel Saunders, Tammy Corica, Derek D’Souza, Richard Sainsbury, Samuele Massarut, Irving Taylor, and Basil Hilaris 

Lancet Oncology March 2004  2004; 5: 165–73 PDF

 

Reducing radiotherapy dose in early breast cancer: the concept of conformal intraoperative brachytherapy

Tobias JS, Vaidya JS, Keshtgar M, D'Souza DP, Baum M.

Br J Radiol. 2004 Apr;77(916):279-84. PDF

 

Functional maps of metastases from breast cancers: proof of the principle that multidimensional scaling can summarize disease progression

Lincoln C. Gray, Jayant S Vaidya, Michael Baum, Rajendra A. Badwe, Indraneel Mittra, Tariq Siddiqui, Dorothea Wiarda,

World Journal of Surgery, Jul 2004;28(7): 646–651 PDF

 

Therapy of breast diseases: experts’ overview

Vaidya JS

Br Cancer Res. 26 Jan 2005; 7:59-60 WWW  PDF

 

 TARgeted Intraoperative radiotherapy (TARGIT): An innovative Approach to Partial-breast irradiation

Vaidya JS, Tobias JS, Baum M, et al

Sem Rad Oncol April 2005; 15: 84-91 PDF

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A mathematical model for the effect of false negative rate of sentinel node biopsy on breast cancer mortality – a tool for everyday use.

Vaidya JS, Dewar JA, Brown DC, Thompson AM

Breast Cancer Research 15 August 2005, 7:225-227 WWW PDF

 

Screening for disease: the good, the bad and the thoughtful.

Vaidya JS

Int J Surgery, 2005 (3): 107-112 PDF.

 

 Does screening mammography cause cancers? True unless we accept that we are overdiagnosing invasive cancers by a factor of 2.

Vaidya JS,

BMJ 16 May 2005 http://bmj.bmjjournals.com/cgi/eletters/330/7497/936#106627

 

Breast conserving Surgery with Intra-operative Radiotherapy:  The Right Approach for the 21st Century?

JS Tobias, JS Vaidya*, M Keshtgar, M Douek, M Metaxas, C Stacey, D D’Souza, R Sainsbury, M Baum

Clinical Oncology.  2006;18: 220-228 PDF

This was one of the top 10 papers downloaded from the journal in 2006 

 

A mathematical model for therapeutic effect of different radiotherapy strategies

Henderling H*, Chaplain MAJ, Anderson S, Munro AJ, Vaidya JS*

J Theor Biol  (Epub 28 Dec 2005) 2006 Jul 7;241(1):158-71. PDF

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Single dose targeted intraoperative radiotherapy (TARGIT) for breast cancer can be delivered as a second procedure under local anaesthetic

Jayant S Vaidya, Lynn Walton and John Dewar.

World Journal of Surgical Oncology 2006, 4:2 doi:10.1186/1477-7819-4-2 http://www.wjso.com/content/4/1/2    PDF

 

(Book chapter) Intraoperative radiotherapy: an elegant approach to partial breast irradiation. 

Vaidya Jayant S 

In Accelerated partial breast irradiation for breast cancer. Ed Wazer D, Arthur D, Vicini A.  Springer 2006 PDF

 

(Letter) Increased tissue stiffness during mammography may contribute to carcinogenesis

Jayant S Vaidya, Samuele Massarut.

Int J Surgery 2007 Jun;5(3):213. Epub 2006 Jul 3 2006 http://dx.doi.org/10.1016/j.ijsu.2006.05.021  PDF

 

Eyes do not see what the mind does not know - A desmoid tumour in the breast

Jayant S. Vaidya a,*, Peri Kocabayoglu, Denis McLean, Lee Jordan.

Int J Surgery  (Epub 7 Jul 2006) http://dx.doi.org/10.1016/j.ijsu.2006.05.022   PDF

 

An alternative model of cancer cell growth and metastasis.

Jayant S Vaidya.

Int J Surgery. 2007;5(2):73-75 (Epub 14 Jul 2006) http://dx.doi.org/10.1016/j.ijsu.2006.06.003 PDF
 

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(Letter) An uncommon scintiscan during sentinel node biopsy- an optical illusion.

Jayant S Vaidya, Michael Osborne. 

Int J Surgery. (Epub 1 Aug 2006) http://dx.doi.org/10.1016/j.ijsu.2006.05.025 PDF

 

(Editorial) In favour of partial breast irradiation in selected patients and a well directed intraoperative boost.

Jayant S Vaidya.

The Breast. 2006;15(5):581-583 (Epub 21 Aug 2006) doi:10.1016/j.breast.2006.06.001 PDF

 

Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost.

Jayant S Vaidya, Michael Baum, Jeffrey S Tobias, Samuele Massarut, Frederik Wenz, Olive Murphy, Basil Hilaris, Joan Houghton, Christobel Saunders, Tammy Corica, Mario Roncadin, Uta Kraus-Tiefenbacher, Frank Melchaert, Mohammed Keshtgar, Richard Sainsbury,
Michael Douek, Eleanor Harrison, Alastair M Thompson, David Joseph

Int J Rad Oncol Biol Phys 2006;66(5):1335-1338 doi:10.1016/j.ijrobp.2006.07.1378  PDF preprint

 

Locally advanced breast cancer in a 15th century painting in Milan

Jayant S Vaidya

The Breast  2007; 16(1):102-103 (Epub 1 Nov 2006) doi:10.1016/j.breast.2006.09.002

 

A mathematical model of breast cancer development, local treatment and recurrence
Enderling H, Anderson ARA, Chaplain MAJ and Vaidya JS
J Theor Biol 2007;246(2);245-259  (Epub12 Dec 2006)  doi:10.1016/j.jtbi.2006.12.010.
 

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Partial breast irradiation using targeted intraoperative radiotherapy (Targit).

Jayant S Vaidya

Nat Clin Pract Oncol. (Epub 5 Jun 2007). 2007; 4(7), 384-385 doi:10.1038/ncponc0850

 

Breast cancer: an artistic view

Jayant S Vaidya

Lancet Oncology 2007;8(7):583-585 doi:10.1016/S1470-2045(07)70200-0 


Targeted Intraoperative radiotherapy (TARGIT) impairs surgical wound-stimulated breast cancer cell proliferation and invasion

Barbara Belletti, Jayant S. Vaidya, Sara D’Andrea, Frank Entschladen, Mario Roncadin,

Francesca Lovat, Stefania Berton, Tiziana Perin, Ezio Candiani, Sonia Reccanello,

Andrea Veronesi, Vincenzo Canzonieri, Mauro G. Trovň, Kurt S. Zaenker, Alfonso Colombatti,

Gustavo Baldassarre and Samuele Massarut.

Clinical Cancer Resarch 2008;14(5):1325-1332. Journal website doi:10.1158/1078-0432.CCR-07-4453

 

Dynamic response to heat- a novel physical characteristic of breast cancer.

Chengli Song, Colin Purdie, Stuart Brown, Tim Frank, Jayant S Vaidya*

Int J Surgery 2008 in press Pre print of accepted manuscript Journal website doi:10.1016/j.ijsu.2008.02.002 PDF

When a breast specimen is heated- the cancer warms up less than the normal tissues. Generated some worldwide media interest    PDF of a sample

 

Reduction in HRT use is not associated with a reduction in breast cancer incidence in Scotland

Jayant S Vaidya

Journal of National Cancer Institute 2008 April 8,  doi:10.1093/jnci/djn080 PDF

 

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Method to Test Whether Late Extended Letrozole, Rather Than Self- Selection, Improves the Outcome in Patients With Breast Cancer Who Have Completed 5 Years of Tamoxifen

Jayant S Vaidya

Journal of Clinical Oncology 2008 July 1, 26(19):3291 DOI: 10.1200/JCO.2008.17.2809

 

Targeted intra-operative radiotherapy—TARGIT for early breast cancer: Can we spare the patient’s daily journeys to the radiotherapist?
Michael Baum and Jayant S Vaidya
Annals of New York Academy of Sciences Sep 2008,1138:132–135 Journal website doi: 10.1196/annals.1414.019