Epigenetic inheritance and obesity
10 March 2017
Dr David Williams and the maternal medicine team have been awarded £900,000 from the Medical Research Council (MRC) to investigate whether the chemistry around genes (epigenetic change) is altered with obesity and whether this epigenetic change is reversed with weight-loss (bariatric) surgery.
The project will start in March 2017 in collaboration with
Professor Rachel Batterham, Obesity, Diabetes and Endocrinology, UCL,
Professor Vardhman Rakyan, Blizzard Institute, QMUL and Professor Per
Magnus of the Norwegian Mother and Child Cohort (MoBa Study). These
studies are coordinated with ongoing research that is investigating
whether epigenetic change in the germline (sperm) of obese fathers can
be identified in the blood of their newborn offspring. Taken together,
these studies will determine the value of paternal and maternal weight
loss before conception to optimize fetal growth and reduce the risk of
that newborn to develop obesity and diabetes in later life.