Wolfson Institute for Biomedical Research
MRes Drug Design
Graduate Tutor: Dr Edith Chan
Tel: 020 7679 6710
Drug design is an integral part of the pharmaceutical and biotech industries and the UCL Division of Medicine and Wolfson Institute for Biomedical Research are particularly well equipped to train the next generation of drug discovery biologists and chemists in the field, especially in Drug Discovery projects. This new programme complements UCL’s existing Drug Design MSc and is designed for the more research-oriented student.
What will I learn?
This new programme teaches students the latest methodologies and approaches and covers all aspects of drug design – drug discovery, computational and structural biology, screening, assay development, medicinal chemistry, and most importantly the industrial practices involved in modern drug design technology.
Availability: Full-time 1 year
Students undertake modules to the value of 180 credits. The programme consists of five taught modules (75 credits), and a research/dissertation (105 credits).
Students will select three from the following Drug Design MSc core modules:
- Bioinformatics and Structural Biology as applied to Drug Design
- Target Identification, Pharmacology and High Throughput Screening
- Cheminformatics and Modelling for Drug Design
- Biological Molecules as Therapeutics - Antibodies, siRNA, and Stem Cells
- Biophysical screening methods, X-ray crystallography, protein NMR and phenotypic screening.
- Fragment-based Drug Design
- Target Selection – Scientific Grounds
- Commercial and Intellectual Property Aspects
Plus two taught transferable skills modules delivered by CALT (UCL Centre for the Advancement of Learning and Teaching):
- Investigating Research
- Researcher Professional Development
Research Project and Dissertation
All students undertake an independent research project which culminates in a dissertation of 15,000 to 20,000 words. Research project - minimum 5 months and can be selected from expert groups in UCL - e.g. Cancer Institute, Royal Free Hospital, MRC Laboratory for Molecular Biology, Medicine, etc. Examples of research projects are as follows:
|Screening, Biology, Cell Biology and Biochemistry|
|Optimization of small molecule drug inhibition of a kinase targets for therapy of Polycystic Kidney Disease|
|Towards novel antibiotics: small molecule inhibitors of the serine/threonine protein kinases of Gram positive bacterial pathogens|
|Probing host-HIV interactions using small molecule inhibitors|
|Exploration of a new scaffold as a potential new class of a kinase inhibitor|
|Modified analogues of an established scaffold with potential for the treatment of neurodegenerative conditions|
|Computational, Cheminformatics, Bioinformatics, and computer-based literature projects|
|Drug repositioning using internal technology|
|Fragment-based design of peptidomimetic drugs|
|Natural hormones and neurotransmitters as drug leads|
|Structural and Molecular Biology|
|Crystal structure determination of protein-ligand complexes|
|Cloning and NMR study of Drug protein target|
|PK/ADME, Assay development|
|Development of PK/ADME assay for a Cancer project|
Teaching and Learning
The programme is delivered through a combination of lectures, seminars, tutorials and problem classes, critical journal clubs and research project. Assessment is through coursework, practicals, laboratory work, examination, dissertation and oral presentation.
There are no optional modules for this programme.
Programme Director - Professor David Selwood
Professor Selwood is a medicinal chemist with 12 years experience in big pharma at the Wellcome Foundation latterly Glaxo-Wellcome. Whilst at Wellcome Prof Selwood worked on the successful anti-migraine drug zolimitriptan (over $1 billion dollars in sales) and also invented GW4991W94 a compound which completed phase 2 clinical trials.
Prof Selwood moved to UCL in December 1995 to become head of the chemistry group at the Wolfson Institute for Biomedical Research. He founded several spin out companies: ProAxon Ltd, NCE discovery (now Domainex) and Canbex Therapeutics, a spin-out company focussed on MS Therapies.
Programme Coordinator - Dr Edith Chan
Dr Chan has over 17 years pharmaceutical and biotech experiences in the area of molecular modeling, cheminformatics, structure/ligand-based drug design, and bio-computing.
She worked in big phama and biotech: Sanofi Aventis and Inpharmatica, which involved all spectrum of drug discovery program. While working in Sanofi Aventis, she helped design ICE inhibitors, one of which has achieved Phase II status. She joined UCL in 2009 and her research is focused on computational drug design.
Graduate Tutor - Dr Andrei Okorokov
Dr Okorokov's research interest is in cell, molecular and structural biology of the protein machineries and signalling pathways controlling and maintaining the integrity of our chromosomes.
An upper second-class UK Bachelor’s degree in a relevant subject (for example, life sciences, medicine, chemistry ) or an overseas qualification of an equivalent standard, or an appropriate professional qualification, or a minimum of three years’ relevant work experience.
English level: Standard
How to apply
You may choose to apply online or download application materials, for details visit www.ucl.ac.uk/gradapps
Students are advised to apply as early as possible due to competition for places. Those applying for scholarship funding (particularly overseas applicants) should take note of application deadlines. The deadline for application is 15 August 2014.(Wording for this para – additional how to apply statement - can be altered up to maximum of 100 words)
Who can apply?
This MRes is ideal for suitably qualified graduates who wish to obtain a broad understanding of the drug design process, either to establish a career in drug discovery, or to undertake further research in this field. It is also suitable for industry professionals wishing to refresh their existing knowledge and skills and become familiar with cutting-edge research and developments.
What are we looking for?
When we assess your application we would like to learn:
- why you want to study Drug Design at graduate level
- why you want to study Drug Design at UCL
- what particularly attracts you to the chosen programme
- how your academic and professional background meets the demands of this challenging programme
- where you would like to go professionally with your degree
Together with essential academic requirements, the personal statement is your opportunity to illustrate whether your reasons for applying to this programme match what the programme will deliver. Applicants who have a portfolio are strongly recommended to submit it when they apply.
Contact: Dr Edith Chan
Tel: +44 (0)20 7679 6710
|UK/EU 2014/15||Overseas 2014/15|
|£8500 (FT)||£21,700 (FT)|
FundingTwo bursaries of £2500 each will be awarded to applicants based on their academic excellence. Apply to UK and EU students only.
For those students working to organize scholarship funding (particularly overseas applicants), early application for admission is strongly encouraged (preferably by May 1st for the following academic year).
Links to UCL information for prospective students on scholarships and funding.
Links to UCL and Santander Master's Scholarships.
The post genomics era has brought a basic change in traditional drug discovery. This programme reflects the rapid changes in this subject in the last few years.
Research Assessment Rating
75% rated 4* (world-leading) or 3* (internationally excellent)
UCL Division of Medicine