Wolfson Institute for Biomedical Research
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Medicine News

CABI at Royal Society Summer Science Exhibition 2014

Published: Jun 30, 2014 4:22:47 PM

UCL Stroke Case Collection (UStroc)

Published: Jun 30, 2014 4:17:48 PM

Rajiv Jalan

Published: Jun 30, 2014 11:28:01 AM

Teaching

Researchers within the Wolfson Institute for Biomedical Research contribute to several distinguished taught courses at UCL.

Programmes available

Testimonials

Georgia Denning

"The broad range of topics covered during the course gave me an intricate understanding of all aspects of drug discovery, consisting of a range of cutting edge skills and techniques in molecular modelling and chemoinformatics to bioinformatics and even evaluation of patenting within the pharmaceutical industry. These skills are reinforced with an even greater theoretical knowledge via the modules studied, with lectures being delivered from leading experts in their fields whether that be academia or industry.

"This course sets you up with a comprehensive knowledge and understanding that is essential to break into the world of pharma, I personally found myself drawn to the fast paced environment of industry and with much thanks due to the MSc in Drug Design at UCL I now work as a chemoinformatician for one of the worlds leading pharmaceutical companies.

"Having studied for a BSc in Biological Sciences at the University of Exeter I found that I was intrigued by the evolution and treatment of disease and the modules studied during the MSc in Drug Design at UCL gave me a fantastic opportunity to delve further into the drug discovery process." Georgia Dennin (2011) Cheminformatian at AstraZeneca

Lorcan Browne

"The course itself exposed me to a range of techniques and skills; including the use of Molecular Modelling software and Statistical analysis programmes. It also delivering a broad range of lecture topics; from stem cell research and pharmacogenomics to X-ray crystallography and NMR, from both lectures in UCL and experts from industry.

"I plan to continue on to do a PhD and feel that this master provides a comprehensive background in many of the tools and techniques that are employed at the frontier of research today.

"My background was primarily Organic Chemistry, but I was more interested in pursuing the Medicinal side of chemistry so the MSc in Drug design provided a great oppurtunity to devolop my knowledge and skills in this area. I chose UCL for its great reputation and for its role as one of the top research colleges in Europe." Lorcan Browne (2011)  PhD studentship at UCL, UK

Sami Jaffar

"Having read a first degree in Chemistry, the MSc in Drug Design at UCL was a fantastic opportunity to equip myself with the cutting-edge techniques that drive innovation at the forefront of Big Pharma and Biotech.

The comprehensive nature of the course allowed me to develop in-depth knowledge of aspects essential to Drug Discovery & Design. Modules covering Fragment Based Drug Design, Molecular Modelling and Cheminformatics were especially interesting, with specialist lectures being delivered by leading speakers from academia and industry, such as GSK, Cresset & Astex Pharmaceuticals – providing an invaluable insight into current industry opinion.

I believe the MSc Drug Design at UCL is essential for anyone looking to gain entry into a career in Pharma or Academia. It certainly sets you apart from the 'crowd'.Sami Jaffar (2011) PhD studentship at Oxford University, UK

Graduate Progression

PhD Studentships

UK

  • Oxford University
  • UCL
  • Imperial College
  • Southampton

Europe

  • SEMM European School of Molecular Medicine, University of Milan, Italy
  • Institut Laue-Langevin, Grenoble, France
  • TUM - Technische Universität München, Germany
  • Pier Helmholtz Graduate School, Hamburg, Germany
  • European Molecular Biology Laboratory, Heidelberg, Germany
  • University of Würzburg, Germany
  • ETH Zurich, Switerland

USA and others

  • Univeristy of Kanas, USA
  • Fudan University, China

Jobs in Industry

  • Cheminformatian, AstraZeneca, UK
  • Database Administrator, ACM Global, UK
  • Account Manager, Genesis Medical, UK
  • Sales Engineer , COMSOL, UK
  • Business development, DSGI, UK
  • Teaching positions, Universities, UK
  • Research Associates, Universities, UK and Overseas

Resources

Here is a list of commerical and academic software, databases and programs that we use in our degree programme. We are grateful that these organisations and their scientists grant us the permission to use them.

UCL

Software

Comprehensive:
MOE (CCG) - Comprehensive computational software for Drug Discovery process

Molecular Modeling/Cheminformatics:
Pipeline Pilot (Accelrys)- Comprehensive cheminformatics tools 
Cresset Field Technolgy - molecular Field technology 
GOLD (CCDC) - Protein-Ligand Docking 
YASARA (Yasara) - Modeling and SImulation 
Accelrys Draw (Accelrys) - Chemical structure drawing tool, Tutorial
COOT - Crystallographic Object-Oriented Toolkit

Bioinformatics:
BioEdit - Biological sequence alignment editor 
PyMOL - Open-source molecular graphics visualisation, PyMOL examples
RasMol - Molecular graphics visualisation 
Swiss-Pdb Viewer - PDB viewer

Others:
Origin (OriginLab) - Data analysis, publication-quality graphing, and programming. 

Databases

Codon usage database - Codon usage database

DrugBank - Drug/Target information

EBI - EBI home

ExPASy - ExPASy proteomics server 

NCBI - NCBI home 

PDB - Research Collaboratory for Structural Bioinformatics (RCSB) 

PDBsum - Summaries and structural analyses of PDB data files 

Swiss-Prot - Protein sequence and function 

Mobyle@pasteur - codon calculation 

UniProt - Protein sequence and functio

Web programs

NCBI Blast - Similarity between biological sequences

Optimizer - Optimize a DNA or protein sequence 

phyre - Protein Homology/analogY Recognition Engine 

RaCC - Rare Codon Calculator 

Rare codon search (Bioline) 

Reading Materials

Please do not feel obliged to buy all these books as together, they will be expensive.

You can find some of these in the Library.

Another good resource is the NCBI Bookshelf.

More importantly, read research articles and reviews from E-journals which are free from UCL Library Services.

Throughout the course, lecturers will also provide PDFs of specialized materials from Journals.

Drug discovery
Discovery and development of sorafenib
A New Class of Raf Kinase Inhibitors
Fragment-Based Drug Discovery Applied to Hsp90
A Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design
Can the pharmaceutical industry reduce attrition rates?
Rebuilding big pharma's business model
 
Bioinformatics
Applied Bioinformatics: An Introduction, Selzer et al
Essential Bioinformatics , Xiong
Bioinformatics (Advanced Texts) , Orengo et al
Understanding Bioinformatics, Zvelebil et al
Structural Bioinformatics, Gu, Bourne (eds)
 
Structural biology
Protein Structure and Function (Primers in Biology), Petsko et al
 
Cheminformatics / modelling of drugs
An Introduction to Chemoinformatics
An Introduction to Medicinal Chemistry
Fundamentals of Medicinal Chemistry
Chemistry of Drugs (New Chemistry)
 
Biological molecules as therapies
Computational Structural Biology: Methods And Applications
 
Biology of drug discovery programmes
Calorimetry and thermodynamics in drug design
 
FBDD
The rise of fragment-based drug discovery
The benefits of constructing leads from fragment hits
Design of HSP90 inhibitors
 
Target selection
Target selection in drug discovery