The Wolfson Institute for Biomedical Research
at the Cruciform Building
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Prof. Michael Häusser FMedSci

- 020 7679 6756 / m.hausser@ucl.ac.uk

Neural Computation

Our group is interested in understanding the cellular basis of neural computation in the mammalian brain. Specifically, we are investigating how the integrative properties of neuronal dendrites and the anatomical and functional connectivity of neural circuits contribute to coding and processing of information in the intact brain. We have chosen the cerebellum and neocortex as our model systems, where we use a combined strategy of in vitro and in vivo imaging and electrophysiology, taking advantage of a range of high-tech approaches developed in the lab. These include two-photon imaging techniques, patch-clamp recordings from axons and dendrites and simultaneous recordings from multiple synaptically connected cells. Our experiments are complemented by computational models of single neurons and networks of neurons. At each stage of our work, our aim is to link different levels of brain function, in order to reveal how activity in single neurons and neural circuits encodes defined behaviours and, importantly, what kinds of changes take place within these circuits during learning. 

also see our Neural Computation Lab page.

 

Selected publications

Packer, A, Roska, B, Häusser, M (2013). Targeting neurons and photons for optogenetics. Nature Neuroscience 16:805-15.

Schmidt-Hieber, C, Häusser, M (2013). Cellular mechanisms of spatial navigation in the medial entorhinal cortex. Nature Neurosci. 16(3):325-31

Smith, SL, Smith IT, Branco T, Häusser M (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature 503:115-20

Haider B, Häusser M, Carandini M (2013). Inhibition dominates sensory responses in the awake cortex. Nature 493:97-100.

Branco T, Häusser M. (2011). Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69:885-92..

 

Academic Career

2011-present Wellcome Trust Principal Research Fellow and Professor of Neuroscience - UCL

2012 FMedSci

2001-2011 Wellcome Trust Senior Research Fellow and Professor of Neuroscience - UCL

1997-2001 Wellcome Trust Career Development Research Fellow -UCL

1995-1997 Postdoc with Philippe Ascher - Ecole Normale Superieure, Paris, France

1992-1995 Postdoc with Bert Sakmann - Max Planck Institute for Medical Research, Heidelberg

1992 PhD University of Oxford


Funding

ERC

Wellcome Trust

Gatsby Charitable Foundation

 


Wolfson Institute for Biomedical Research - The Cruciform Building - University College London
Gower Street - London - WC1E 6BT -------------------------- Telephone: +44 (0)20 7679 2000 Copyright © 1999-2008 UCL