Prof. Michael Häusser FMedSci
- 020 7679 6756 / email@example.com
Our group is interested in understanding the cellular basis of neural computation in the mammalian brain. Specifically, we are investigating how the integrative properties of neuronal dendrites and the anatomical and functional connectivity of neural circuits contribute to coding and processing of information in the intact brain. We have chosen the cerebellum and neocortex as our model systems, where we use a combined strategy of in vitro and in vivo imaging and electrophysiology, taking advantage of a range of high-tech approaches developed in the lab. These include two-photon imaging techniques, patch-clamp recordings from axons and dendrites and simultaneous recordings from multiple synaptically connected cells. Our experiments are complemented by computational models of single neurons and networks of neurons. At each stage of our work, our aim is to link different levels of brain function, in order to reveal how activity in single neurons and neural circuits encodes defined behaviours and, importantly, what kinds of changes take place within these circuits during learning.
also see our Neural Computation Lab page.
Schmidt-Hieber C, Häusser M. (2013). Cellular mechanisms of spatial navigation in the medial entorhinal cortex. Nature Neurosci. 16(3):325-31
Branco T, Clark BA, Häusser M. (2010). Dendritic discrimination of temporal input sequences in cortical neurons.
London M, Roth A, Beeren L, Häusser M, Latham PE. (2010). Sensitivity to perturbations in vivo implies high noise and suggests rate coding in cortex.
Mathy A, Ho SS, Davie JT, Duguid IC, Clark BA, Häusser M. (2009). Encoding of oscillations by axonal bursts in inferior olive neurons.
Watt AJ, Cuntz H, Mori M, Nusser Z, Sjöström PJ, Häusser M.
(2009).Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity.
Nature Neurosci. 12(4):463-73.
Kitamura K, Judkewitz B, Kano M, Denk W, Häusser M.
(2008). Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo.
Nature Methods. 5(1):61-7.
2011-present Wellcome Trust Principal Research Fellow and Professor of Neuroscience - UCL
2001-2011 Wellcome Trust Senior Research Fellow and Professor of Neuroscience - UCL
1997-2001 Wellcome Trust Career Development Research Fellow -UCL
1995-1997 Postdoc with Philippe Ascher - Ecole Normale Superieure, Paris, France
1992-1995 Postdoc with Bert Sakmann - Max Planck Institute for Medical Research, Heidelberg
1992 PhD University of Oxford
Gatsby Charitable Foundation