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Wolfson Institute for Biomedical Research

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David B Sattelle

Molecular Neurobiology
David B Sattelle

Tel: 020 7679 6613
Email: d.sattelle@ucl.ac.uk

We are interested in the mechanisms underlying neurodegenerative and neuromuscular diseases and in exploring new routes to therapy. We address these goals using the powerful genetic model organism Caenorhabditis elegans with its transgenic lines, mutants as well as access to forward and reverse genetics. We are currently focussing on Alzheimer's disease, Fronto-Temporal Dementia, Spinal Muscular Atrophy and Congenital Myasthenia. We have developed high-throughput, automated, phenotyping, which permits library-scale, in vivo, drug screening of our disease models with the aim of finding new or re-profiled drugs to ameliorate symptoms of these devastating diseases.

We also study human ligand-gated ion channels as targets for drugs aimed at ameliorating symptoms of nervous system disorders. Invertebrate ligand-gated ion channels are investigated as targets for drugs / chemicals with benefits for animal health and agriculture. 

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