Andrei image 1Andrei image 2Andrei image 3Andrei image 4

Andrei L. Okorokov

Transcriptional and post-transcriptional control of pain
Andrei L Okorokov Photo

020 7679 0959

Pain is a major clinical problem and affects more people than diabetes, heart disease and cancer combined. Pain is a cofactor in many medical conditions yet pain medicines are often only partially effective, and the problem is increasing with an aging population. By understanding the cellular and molecular processes that lead to the sensation of pain, more effective targeted therapies can be developed to alleviate suffering.

One way of doing so is analysing genetic conditions in which patients have altered levels of pain sensitivity, in particular the cases where pain sensitivity and perception are diminished. Identifying human genes, which are responsible for such a phenotype and their functional products, allows us to pinpoint the key players in the chain of molecular events providing for pain sensation.

After two decades of work in transcriptional and post-transcriptional regulation of tumour suppression (p53 field), I am now establishing a new research direction into the transcriptional and post-transcriptional regulation of pain pathways.

Academic Career

  • 2004-date Lecturer, UCL, WIBR, London
  • 2002-2004 Senior Research Fellow, Birkbeck College, London
  • 1995-2002 Postdoc, University of York
  • 1991-1994 Researcher,Engelhardt Institute of Molecular Biology, Moscow
  • 1987-1991 PhD, Moscow All-Union Institute of Genetics


Kearns, S., Lurz, R., Orlova, E. V., & Okorokov, A. L. (2016). Two p53 tetramers bind one consensus DNA response element. Nucleic Acids Res. doi: 10.1093/nar/gkw215 free access

Koenig J, Werdehausen R, Linley JE, Habib AM, Vernon J, Lolignier S, Eijkelkamp N, Zhao J, Okorokov AL, Woods CG, Wood JN, Cox JJ. (2015)  Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia.  PLoS One. 2015 Jun 2;10(6):e0128830. free access

Fatoba ST, Tognetti S, Berto M, Leo E, Mulvey CM, Godovac-Zimmermann J, Pommier Y, Okorokov AL. (2013) Human SIRT1 regulates DNA-binding of the Mcm10 DNA replication factor via deacetylation. Nucleic Acids Res. 41(7):4065-79 free access

Fatoba ST, Okorokov AL. (2011) Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation. Cell Cycle. 10(14):2317-22. free access

Aramayo R, Sherman MB, Brownless K, Lurz R, Okorokov AL, Orlova EV. (2011) Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance. Nucleic Acids Res. 39(20):8960-71. free access

Okorokov AL, Orlova EV. (2009) Structural biology of the p53 tumour suppressor. Curr Opin Struct Biol. 19(2):197-202. free access

Further publication information can be viewed at