Wolfson Institute for Biomedical Research
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Our group is interested in understanding the cellular basis of neural computation in the mammalian brain. Specifically, we are investigating how the integrative properties of neuronal dendrites and the anatomical and functional connectivity of neural circuits contribute to coding and processing of information in the intact brain.
We have chosen the cerebellum and neocortex as our model systems, where we use a combined strategy of in vitro and in vivo imaging and electrophysiology, taking advantage of a range of high-tech approaches developed in the lab. These include two-photon imaging techniques, patch-clamp recordings from axons and dendrites and simultaneous recordings from multiple synaptically connected cells.
Our experiments are complemented by computational models of single neurons and networks of neurons. At each stage of our work, our aim is to link different levels of brain function, in order to reveal how activity in single neurons and neural circuits encodes defined behaviours and, importantly, what kinds of changes take place within these circuits during learning.
- 2011-present Wellcome Trust Principal Research Fellow and Professor of Neuroscience - UCL
- 2012 FMedSci
- 2001-2011 Wellcome Trust Senior Research Fellow and Professor of Neuroscience - UCL
- 1997-2001 Wellcome Trust Career Development Research Fellow -UCL
- 1995-1997 Postdoc with Philippe Ascher - Ecole Normale Superieure, Paris, France
- 1992-1995 Postdoc with Bert Sakmann - Max Planck Institute for Medical Research, Heidelberg
- 1992 PhD University of Oxford
Packer, A, Roska, B, Häusser, M (2013). Targeting neurons and photons for optogenetics. Nature Neuroscience 16:805-15.
Schmidt-Hieber, C, Häusser, M (2013). Cellular mechanisms of spatial navigation in the medial entorhinal cortex. Nature Neurosci. 16(3):325-31
Smith, SL, Smith IT, Branco T, Häusser M (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature 503:115-20
Haider B, Häusser M, Carandini M (2013). Inhibition dominates sensory responses in the awake cortex. Nature 493:97-100.
Branco T, Häusser M. (2011). Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69:885-92..
Further publication information can be viewed at https://iris.ucl.ac.uk/iris/browse/profile?upi=MHAUS91