Design of novel non-peptide agonists for NPR-C

Key biological collaborator: Dr Adrian Hobbs , UCL; Dr Snezana Djordjevic , UCL

Natriuretic peptides are large cyclic peptides that bind three related receptors NPR1-3. The third receptor NPR1 or NPRC is present in high concentration in cardiovascular and peripheral tissues, it is a potent relaxant of arterial and venous smooth muscle. Small molecule NPR3 agonists are potential treatments for heart failure and ischaemic reperfusion injury.

References

Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ, Hobbs AJ.
Am J Respir Crit Care Med. 2008 Oct 15;178(8):861-9. Epub 2008 Aug 8.

C-type natriuretic peptide