The Wolfson Institute for Biomedical Research
at the Cruciform Building
UCL logo

Dr. Ingvar Ferby
- 020 7679 6293 / i.ferby@ucl.ac.uk

Cell Signalling Group

Lab summary

The EGF receptor family of growth factor receptors (the ErbB family) regulates complex morphogenetic processes during development and tissue homeostasis.

To date we know a lot about the canonical signalling pathways triggered upon receptor activation. However, little is known about the negative regulatory circuits that ensure accurate spatial and temporal signal attenuation.

In recent years numerous negative regulators of the ErbB receptors have been identified, such as Mig6, LRig, Argos, Sprouty and Spred. Loss of function genetics of some of these players reveals their important role in regulating cell fate decisions and the balance between cell proliferation and differentiation.

Our group is interested in how negative regulatory circuits of the ErbB signalling network control fundamental biological processes such as:

  • Maintenance and differentiation of epithelial stem cells.
  • Epithelial morphogenesis
  • Epithelial carcinogenesis

Towards this aim we are combining the use of transgenic mouse models and ex vivo primary epithelial cell culture systems with state-of-the-art molecular and proteomic techniques.

Selected publications

Reschke M, Ferby I, Stepniak E, et al. (2009) Mig-6 is a negative regulator of EGFR signaling in hepatocytes and human hepatocellular carcinoma. Hepatology in press.

Ferby I, Reschke M, Kudlacek O, et al. (2006) Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumour formation. Nature Med. 12:568-573.

Gutierrez GJ, Vogtlin A, Castro A, et al. (2006) Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation. Nature Cell Biol. 8:1084-1094.

Antonio C, Ferby I, Wilhelm H, et al. (2000) Xkid, a chromokinesin required for chromosome alignment on the metaphase plate. Cell 102:425-435.

Ferby I, Blazquez M, Palmer A, Eritja R, Nebreda AR. (2000) A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes. Genes Dev. 13:2177-2189.

More...

Academic Career

2007-Date Group Leader, WIBR, UCL

2001-2006 Postdoc, Max-Planck Institute, Munich, Germany

1996-2001 PhD at EMBL, Heidelberg Germany

1992-1996 MSc at Stockholm University, Sweden

Funding

BBSRC

AICR

Royal Soceity


Wolfson Institute for Biomedical Research - The Cruciform Building - University College London
Gower Street - London - WC1E 6BT -------------------------- Telephone: +44 (0)20 7679 2000 Copyright © 1999-2008 UCL