Prof. Gareth H. Williams and Dr. Kai Stoeber
- 020 76796304 / gareth.williams@ucl.ac.uk
- 020 76796302 / k.stoeber@ucl.ac.uk

Chromosomal Replication Group

Lab summary

The initiation of DNA replication is a crucial decision point in cell proliferation. Chromosomal replication lies at the point of convergence of oncogenic signalling pathways and transduction pathways that trigger proliferation. Unlike these complex redundant pathways, there appears to be only a single mechanism of DNA replication initiation that is conserved in all eukaryotic species studied. This feature makes it a potentially attractive target for both diagnostic and therapeutic intervention.

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Selected publications

Ayaru L, Stoeber K, Webster GJ, Hatfield AR, Wollenschlaeger A, Okoturo O, Rashid M, Williams G, Pereira SP. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates. Br J Cancer. 2008 Apr 15; [Epub ahead of print]

Williams GHW and Stoeber K. Cell cycle markers in clinical oncology.Curr Opin Cell Biol. 2007 Dec;19(6):672-9

Kulkarni AA, Loddo M,Leo E, Rashid M, Eward KL, Fanshawe TR, Butcher J, Frost A, Ledermann JA, Williams GH and Stoeber K. DNA replication licensing factors and Aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma. Clin Cancer Res. 2007 Oct 15;13(20):6153-61

Okorokov AL, Waugh A, Hodgkinson J, Murthy A, Hong HK, Leo E, Sherman MB, Stoeber K, Orlova EV, Williams GH. Hexameric ring structure of human MCM10 DNA replication factor. EMBO Rep. 2007 Oct;8(10):925-30

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Academic Career

Funding

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