The Wolfson Institute for Biomedical Research
at the Cruciform Building
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CANCER RESEARCH U.K.
VIRAL ONCOLOGY GROUP

Translational Cancer Research

Nadege Presneau PhD
Cecilia Lai PhD

SARCOMA: Synovial sarcoma (SS) is a highly malignant tumour that is characterized by a chromosomal translocation t(X;18)(p11.2;q11.2) and accounts for 10% of soft tissue tumours. SS can be distinguished into two histological subtypes: biphasic (BSS), containing both epithelial-like cells and spindle cells and monophasic (MSS), containing predominantly spindle cells. Nadege Presneau studies the biology of synovial sarcoma (SS) and particularly the mechanism of epithelial differentiation that occurs in BSS. This would permit us to identify targets that could be useful for diagnosis and developing specific treatment for this aggressive disease.

LUNG CANCER: We are working on a biological study associated with a large randomized Phase III clinical trial (TOPICAL, Dr Ming Lee) on Tarceva (Erlotinib, Roche), an anti-EGFR small molecule, in non-small cell lung cancer (NSCLC). The study investigates the clinical benefit (survival and response rate) of Tarceva, versus placebo in individuals with NSCLC, too ill for conventional cytotoxic therapy. Cecilia Lai will uncover germline and somatic genetic variations in these patients, and correlate their genetic profiles with the clinical benefits they derived from receiving treatment. This information should provide insight into the possibility of personalized medicine using targeted cancer therapy.



Selected publications

Academic Career

Funding

 


Wolfson Institute for Biomedical Research - The Cruciform Building - University College London
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