CANCER RESEARCH U.K.
VIRAL ONCOLOGY GROUP

Laboratory Director: Chris Boshoff MRCP PhD FMedSci

Themes of Research:

STEM CELLS	Mark Clements PhD Lucy Smithers PhD (with Roger Pederson, Cambridge) Claire Westwood, PhD student Sonja Vujovic, PhD student
VIRAL ONCOLOGY	Dimitrios Lagos PhD Marie Malcles PhD Mark Cannon MD Juan Funes PhD Richard Vart PhD Student
ENDOTHELIAL PRECURSORS	Dimitra Bourboulia PhD Lola Martinez BSc
TRANSLATIONAL CANCER RESEARCH	Nadege Presneau PhD Cecilia Lai PhD
BIOINFORMATICS	Stephen Henderson PhD Matthew Trotter PhD
	Lab staff contact information >

Funding:

Selected Publications:

Boshoff-C, Endo-Y, Collins-PD, Takeuchi-Y, Reeves-JD, Siani-MA, Williams-TJ, Moore-PS, Chang-Y, Weiss-RA. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science. 1997; 278: 290-294

Boshoff-C. Coupling herpesvirus to angiogenesis. Nature 1998, 391: 24-25.

Dupin-N, Fisher-C, Kellam-P, Ariad-S, Tulliez-M, Franck-N, van Marck-E, Salmon-D, Gorin-I, Escande-JP, Weiss-RA, Alitalo-K, Boshoff-C. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.
Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4546-51

Radkov-S, Kellam-P, Boshoff-C. The latent nuclear antigen of KSHV targets the retinoblastome-E2F pathway and with the oncogene Hras transforms primary rat cells. Nature Medicine 2000, 6: 1121-1127

Davidovici-B, Karakis-I, Bourboulia-D, Ariad-S, Zong-JC, Benharroch-D, Dupin-N Weiss-RA, Hayward-G, Sarov-B, Boshoff-C. The sero- and molecular epidemiology of KSHV in Israel.
J Natl Cancer Inst 2001, 93: 194-202

Wang-HW, Sharp-T, Koumi-A, Koumi-A, Hollyman-D, Koentges-G, Boshoff-C. Characterisation of an apoptotic glycoprotein encoded by KSHV which resembles a spliced variant of human survivin.
J EMBO 2002, 3;21(11):2602-15

Jenner RG, Maillard K, Cattini N, Weiss RA, Boshoff C, Wooster R, Kellam P. Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile.
Proc Natl Acad Sci U S A. 2003, 100:10399-10404

Bourboulia D, Aldam, D, Lagos, Allen E, Williams I, Cornforth, D, Copas A, Boshoff C. Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia.
AIDS 2004, 18: 485-493

Wang H-W, Trotter_M, Lagos-D, Bourboulia-D, Elliman-S, Mäkinen¬_T, Henderson-_S, Flanagan_AM, Alitalo_K, Boshoff-C. KSHV Cellular Reprogramming Contributes to the Lymphatic Endothelial Gene Expression in Kaposi Sarcoma. Nature Genetics 2004, 36:687-693
http://www.nature.com/ng/journal/v36/n7/abs/ng1384.html

Sharp-TV, Munoz F, Bourboulia D, Presneau N, Darai-E, Wang-H-W, Cannon-M, Burcher-DN, Nicholson-AG, Klein-G, Imreh-S, Boshoff-C. LIMD1, a tumor suppressor at 3p21.3, binds pRb and represses E2F-driven transcription.
Proc Natl Acad Sci 2004; 10: 16531-16536
http://www.pnas.org/cgi/content/full/101/47/16531

McLean-S, Weisz-M, Hartzoulakis-B, Frow-R, Whelan-J, Selwood-D, Boshoff-C. Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala.
Molecular Cancer Therapeutics, in press 2005

Henderson-SR, Presneau-N, Guiliano-D, McLean-S, Frow-R, Anderson-J, Whelan-J, Athanasou-N, Flanagan-A, Boshoff-C. A Molecular Map of Mesenchymal Tumours. Genome Biology, 2005;6(9):R76. Epub 2005 Aug 26
http://genomebiology.com/2005/6/9/R76

Laman H, Funes JM, Ye H, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin C/cdk6.
EMBO J, 2005 Sep 7;24(17):3104-16

Cannon-ML, Cesarman-E, Boshoff-C. The KSHV G protein-coupled receptor inhibits lytic gene transcription in primary effusion lymphoma cells via p21-mediated inhibition of Cdk2.
Blood. 2005 Sep 8; [Epub ahead of print]

Selected Reviews:

Boshoff-C, Weiss-R. Epidemiology and pathogenesis of Kaposi’s sarcoma- associated herpesvirus.
Philos Trans Royal Soc Lond 2001, 356: 517-534

Boshoff-C, Chang-Y. Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus. Annu Rev Med. 2001;52:453-70.

Boshoff-C, Weiss-R. AIDS –related malignancies. Nature Reviews Cancer 2002, 2(5):373-82
http://www.nature.com/nrc/journal/v2/n5/abs/nrc797_fs.html;jsessionid=8AD0BB09F3E2DDD5882D7475F8C1B09C

Boshoff-C. Kaposi virus scores cancer coup and Kohn to Kaposi. Nature Med. 2003 Mar;9(3):261-2.
http://www.nature.com/nm/journal/v9/n3/full/nm0303-261.html

Godfrey-A, Laman-H, Boshoff-C. RNA interference: a potential tool against Kaposi’s sarcoma-associated herpesvirus. Curr Opin Infect Dis. 2003 Dec;16(6):593-600.

Wang-H-W, Boshoff-C. Linking Kaposi virus to cancer-related cytokines. Trends in Molecular Medicine. 2005,11:309-12.

Selected publications

Academic Career

Funding