The Wolfson Institute for Biomedical Research
at the Cruciform Building
UCL logo

CANCER RESEARCH U.K.
VIRAL ONCOLOGY GROUP

Endothelial Precursors

Dimitra Bourboulia PhD
Lola Martinez BSc

We have shown that the genetic profile of Kaposi sarcoma (KS) is closer to that of lymphatic endothelial cells (LECs) than to blood vessel ECs. In addition, that lymphangiogenic molecules including VEGF-D and Angiopoietin-2 are highly expressed in individuals with KS. Adult bone marrow-derived circulating endothelial progenitor cells (CEPs) participate in neoangiogenesis during wound healing, tumour formation and cardiac damage (Figure 4). We hypothesize that CEPs are infected by KSHV and that the virus steers the differentiation of CEPs towards LECs. Lola Martinez and Dimitra Bourboulia have optimised a flow cytometric-based method to identify and characterize CEPs. They will study the role of CEPs during KS formation.


Selected publications

Academic Career

Funding

 


Wolfson Institute for Biomedical Research - The Cruciform Building - University College London
Gower Street - London - WC1E 6BT -------------------------- Telephone: +44 (0)20 7679 2000 Copyright © 1999-2008 UCL