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Published: Apr 13, 2015 12:07:47 PM
Published: Mar 31, 2015 1:47:00 PM
Published: Jan 8, 2015 3:38:17 PM
Light touch (red) and damage-sensing (green and blue) neuron cell bodies from spinal ganglia are the first cells involved in sensing innocuous and painful stimuli. Image courtesy of Dr Simon Beggs..
Image courtesy of Beverley Clark and Michael Hausser.
Purkinje Cell Network
Electronically Coupled Inferior Olive Neurons
A pair of neurons in the inferior olive exhibiting direct coupling via electrical synapses. Simultaneous patch-clamp recordings were made from the two neurons, which were filled with a fluorescent dye and imaged using a confocal microscope. Image courtesy of Beverley Clark and Michael Hausser.
BPAE cells with Mirotracker Red CMXROS (-0005,mitochondria - red), BODIPYFL Phalloidin (-0006, cytoskeleton - green)and DAPI (-0004, nuclei – blue), Molecular Probes FluoCells Prepared Slide #1 Thomas Adejumo.
A network of synthetic neocortical pyramidal cells created using the 'TREES toolbox' software environment. This creates dendritic trees based on local optimization of total wiring and conduction distances which are indistinguishable from dendritic trees of real pyramidal neurons. Michael Hausser..
Inferior Olive Highres
Patch-clamp recordings from inferior olive neurons filled with a fluorescent dye. Michael Hausser..
Pyramidal Call Microcircuit
Receptive Field Map
Receptive field subregion maps (X-Y is visual space, height is normalized spike rate) of the receptive field of three neurons in mouse primary visual cortex depicted using 3D meshes. All three neurons share the same receptive field subregion. Michael Hausser..
Connectivity patterns in inhibitory networks.
Using quadruple patch-clamp recordings from cerebellar interneurons, we found that electrical and chemical interneuron networks in the molecular layer exhibit highly structured nonrandom features of connectivity, including clustered and feedforward motifs. Michael Hausser..
C. elegans connectome
The complete wiring diagram of the nervous system. C. elegans is the only organism where we know the connectome, and it is used by our lab to understand neuronal processing and neurodegenerative disease. Freddie Partridge (Lomas/Sattelle lab).
Calcium-Dependent Protein Kinase 1 (CDPK1)
Cryptosporium parvum is a parasite of major health concern to humans and CDPK1 inhibitors are being developed for the treatment of these infections. Image generated and rendered from PDB 3NCG using PyMOL (TM) 0.99rc6..
Detection of new-born oligodendrocytes in the adult corpus callosum. Biological significance: New oligodendrocytes are produced throughout life in the brain. Confocal imaging. Sarah Jolly (postdoc Richardson lab).
Expression of a GPCR protein in Bergmann glia in the cerebellum. Confocal imaging. Image courtesy of Sarah Jolly.
The activity of neurons in an awake mouse.
When the neurons "light up", they are electrically active, perhaps indicating what the mouse is "thinking" Projection courtesy of Adam Packer (Hausser Lab).
Imaged and stitched using the Leica confocal microcope. This is spinal cord section from an transgenic mouse which reports oligodendrocytes obtained from dorsal and ventral origins simultaneously. Oligodendrocytes from different origins may have different properties and differ in their ability to help and heal in demyelinating diseases like Multiple Sclerosis. (Richa Tripathi).