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John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
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Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials

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Audioslide presentation on Claudia Manzoni's paper examining how fibroblasts with LRRK2 mutations react to starvation conditions and the possible deficits that they have in autophagy.

LRRK2 and autophagy in fibroblasts

In this paper Claudia Manzoni studies how fibroblast cells from people with Parkinson’s disease caused by mutations in LRRK2 react to starvation. Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved – suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles).
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Sybille Dihanich

(Former Post-doctoral Researcher)

I studied Biotechnology at the University of Applied Sciences in Vienna and finished my studies in June 2007. As part of my degree I was working on a 10-months ERASMUS studentship at the Institute of Phsychiatry (King's College London). My work at the IoP was carried out in Dr. Jonathan Cooper's lab which is investigating a group of lysosomal storage disorders called Batten Disease. After finishing my degree I stayed on in the Cooper lab as a PhD student investigating cell renewal (neurogenesis) and microglial biology in various models of Batten Disease. In February 2011 I joined the Department of Molecular Neuroscience where I am working under the supervision of Dr. Patrick Lewis. Within my project I am aiming to characterise the functions and properties of MASL1, one of the ROCO proteins which have an involvement in Parkinson Disease and other disorders.


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Jump to: 2013 | 2012 | 2011 | 2009
Number of items: 6.

2013

Mamais, A; Raja, M; Manzoni, C; Dihanich, S; Lees, A; Moore, D; ... Bandopadhyay, R; + view all (2013) Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases. Neurobiol Dis , 58 pp. 183-190. 10.1016/j.nbd.2013.05.017. Green open access
file

Manzoni, C; Mamais, A; Dihanich, S; Tooze, S; Bandopadhyay, R; Lewis, PA; (2013) LRRK2 regulates autophagy. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 10 - 10).

2012

Dihanich, S; (2012) MASL1: a neglected ROCO protein. Biochem Soc Trans , 40 (5) 1090 - 1094. 10.1042/BST20120127.

Jebelli, JD; Dihanich, S; Civiero, L; Manzoni, C; Greggio, E; Lewis, PA; (2012) GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. Sci Rep , 2 695 - ?. 10.1038/srep00695. Gold open access

2011

Dihanich, S; Manzoni, C; (2011) LRRK2: A Problem Lurking in Vesicle Trafficking? J NEUROSCI , 31 (27) 9787 - 9788. 10.1523/JNEUROSCI.1976-11.2011. Gold open access

2009

Kielar, C; Wishart, TM; Palmer, A; Dihanich, S; Wong, AM; Macauley, SL; ... Gillingwater, TH; + view all (2009) Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease. HUM MOL GENET , 18 (21) 4066 - 4080. 10.1093/hmg/ddp355.

This list was generated on Mon May 25 13:05:59 2015 BST.

Page last modified on 13 aug 13 12:40