UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
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- Clinical Neuroscience
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- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
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Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
You are invited to an evening (13th March 2013) exploring the very latest in cutting edge research into neurodegenerative diseases. Supported by the Wellcome Trust, scientists investigating Alzheimer's, Parkinson's and Motor Neuron disease will explain how our understanding of these disorders is changing in the light of new discoveries in genetics and cell biology, and how these discoveries impact on developing new drugs for these diseases.
18.00 Welcome and introduction
18.10 Lectures commence
I studied Biotechnology at the University of Applied Sciences in Vienna and finished my studies in June 2007. As part of my degree I was working on a 10-months ERASMUS studentship at the Institute of Phsychiatry (King's College London). My work at the IoP was carried out in Dr. Jonathan Cooper's lab which is investigating a group of lysosomal storage disorders called Batten Disease. After finishing my degree I stayed on in the Cooper lab as a PhD student investigating cell renewal (neurogenesis) and microglial biology in various models of Batten Disease. In February 2011 I joined the Department of Molecular Neuroscience where I am working under the supervision of Dr. Patrick Lewis. Within my project I am aiming to characterise the functions and properties of MASL1, one of the ROCO proteins which have an involvement in Parkinson Disease and other disorders.
Link to publications
|Manzoni, C and Mamais, A and Dihanich, S and Tooze, S and Bandopadhyay, R and Lewis, PA (2013) LRRK2 regulates autophagy. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 10 - 10). |
|Dihanich, S (2012) MASL1: a neglected ROCO protein. Biochem Soc Trans , 40 (5) 1090 - 1094. 10.1042/BST20120127. |
|Jebelli, JD and Dihanich, S and Civiero, L and Manzoni, C and Greggio, E and Lewis, PA (2012) GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. Sci Rep , 2 695 - ?. 10.1038/srep00695. |
|Dihanich, S and Manzoni, C (2011) LRRK2: A Problem Lurking in Vesicle Trafficking? J NEUROSCI , 31 (27) 9787 - 9788. 10.1523/JNEUROSCI.1976-11.2011. |
|Kielar, C and Wishart, TM and Palmer, A and Dihanich, S and Wong, AM and Macauley, SL and Chan, CH and Sands, MS and Pearce, DA and Cooper, JD and Gillingwater, TH (2009) Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease. HUM MOL GENET , 18 (21) 4066 - 4080. 10.1093/hmg/ddp355. |
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