UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
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- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
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- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
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One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...
Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...
A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
(Alzheimer's Research Trust Research Fellow)
I studied Biochemistry and Biological Chemistry at the University of Nottingham, where I first became interested in neurodegenerative disease after undertaking a project in Dr Rob Layfield’s laboratory, examining the role of Parkin in Parkinson’s disease. After graduating in 2004, I joined Dr Diane Hanger’s lab at the MRC Centre for Neurodegeneration Research, King’s College London, where I first became interested in the role of the microtubule protein tau in neurodegenerative disease. My PhD was awarded in 2008, and in 2009 I subsequently joined Professor John Hardy’s group in the Department of Molecular Neuroscience, where I am involved in multiple projects investigating the molecular mechanisms of frontotemporal lobar degeneration. My research continues to have a particular focus on tau-mediated neurodegeneration and I was recently awarded a research fellowship from the Alzheimer’s Research Trust to support this work. In addition to my research projects, I also coordinate a BUPA/Alzheimer’s Society funded project (led by Professor Martin Rossor) which aims to generate a biobank of familial dementia patient-derived cell lines.
Page last modified on 20 mar 13 16:58