UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
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- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
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Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
You are invited to an evening (13th March 2013) exploring the very latest in cutting edge research into neurodegenerative diseases. Supported by the Wellcome Trust, scientists investigating Alzheimer's, Parkinson's and Motor Neuron disease will explain how our understanding of these disorders is changing in the light of new discoveries in genetics and cell biology, and how these discoveries impact on developing new drugs for these diseases.
18.00 Welcome and introduction
18.10 Lectures commence
(Former MRC Clinical Research Fellow)
I am an MRC-funded clinical research fellow and trainee in neurology. My interest is in understanding the mechanisms that underpin neurodegeneration, and currently I am using iPS cell models of Parkinson's disease to study the impact of genetic mutations that cause familial Parkinson's disease on human dopaminergic neurons. The overall aim of this work is to help shed light on the biological processes that occur in neurodegeneration, in order to help start to make mechanistic treatments that can change the course of the disease process.
|Toot, S and Hoe, J and Ledgerd, R and Burnell, K and Devine, M and Orrell, M (2013) Causes of crises and appropriate interventions: the views of people with dementia, carers and healthcare professionals. Aging Ment Health , 17 (3) 328 - 335. 10.1080/13607863.2012.732037. |
|Devine, MJ (2012) Patient-derived cell models of Parkinson’s disease. Doctoral thesis, UCL (University College London). |
|Devine, M and Bentley, P and Jones, B and Jenkins, H and Malhotra, P (2011) PERSISTENT PSYCHOSIS IN THREE SUSCEPTIBLE INDIVIDUALS WITH RIGHT INFERIOR FRONTAL LOBE STROKE. In: EUROPEAN JOURNAL OF NEUROLOGY. (pp. 420 - 420). WILEY-BLACKWELL |
|Devine, MJ and Gwinn, K and Singleton, A and Hardy, J (2011) Parkinson's Disease and alpha-Synuclein Expression. MOVEMENT DISORD , 26 (12) 2160 - 2168. 10.1002/mds.23948. |
|Devine, MJ and Kaganovich, A and Ryten, M and Mamais, A and Trabzuni, D and Manzoni, C and McGoldrick, P and Chan, D and Dillman, A and Zerle, J and Horan, S and Taanman, JW and Hardy, J and Marti-Masso, JF and Healy, D and Schapira, AH and Wolozin, B and Bandopadhyay, R and Cookson, MR and van der Brug, MP and Lewis, PA (2011) Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PLOS ONE , 6 (7) , Article e22489. 10.1371/journal.pone.0022489. |
|Devine, MJ and Plun-Favreau, H and Wood, NW (2011) Parkinson's disease and cancer: two wars, one front. NAT REV CANCER , 11 (11) 812 - +. 10.1038/nrc3150. |
|Devine, MJ and Ryten, M and Vodicka, P and Thomson, AJ and Burdon, T and Houlden, H and Cavaleri, F and Nagano, M and Drummond, NJ and Taanman, JW and Schapira, AH and Gwinn, K and Hardy, J and Lewis, PA and Kunath, T (2011) Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. NAT COMMUN , 2 , Article 440. 10.1038/ncomms1453. |
|Gwinn, K and Devine, MJ and Jin, LW and Johnson, J and Bird, T and Muenter, M and Waters, C and Adler, CH and Caselli, R and Houlden, H and Lopez, G and Singleton, A and Hardy, J and Singleton, A (2011) Clinical Features, with Video Documentation, of the Original Familial Lewy Body Parkinsonism Caused By alpha-Synuclein Triplication (Iowa Kindred). MOVEMENT DISORD , 26 (11) 2134 - 2136. 10.1002/mds.23776. |
|Devine, MJ and Lewis, PA (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J , 275 (23) 5748 - 5757. 10.1111/j.1742-4658.2008.06707.x. |
|Devine, MJ and Wilkinson, PA and Doherty, JF and Jarman, PR (2008) Neuroschistosomiasis presenting as brainstem encephalitis. NEUROLOGY , 70 (23) 2262 - 2264. |
|Devine, ME and Fonseca, JAS and Walker, RWH and Sikdar, T and Stevens, T and Walker, Z (2007) Cerebral white matter changes and rate of progression of dementia during cholinesterase inhibitor treatment: a retrospective cohort study. INT J GERIATR PSYCH , 22 (11) 1120 - 1126. 10.1002/gps.1799. |
|Devine, MJ and Duncan, JS (2007) Development of psychogenic non-epileptic seizures in response to auditory hallucinations. SEIZURE-EUR J EPILEP , 16 (8) 717 - 721. 10.1016/j.seizure.2007.06.001. |
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