UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
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Researchers, led by BRC-supported Professor Nicholas Wood, UCL Institute of Neurology, have made a breakthrough in their understanding of Parkinson’s disease after they discovered a chromosome deletion linked to Parkinson’s disease and other genetic disorders. More...
Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...
One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...
Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...
A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
(MRC Post-doctoral Fellow)
As an MBPhD graduate (Cambridge University & University College London) and Academic Clinical Fellow in Neurology (London Deanery), I have been lucky enough to receive training in basic research as well as clinical medicine. I have thoroughly enjoyed both and am committed to pursuing a joint clinical and research career in neuroscience. However, I am fully aware that the gap between clinical realities and basic research can be hard to bridge.
During my PhD I investigated the role of a specific signalling system, purinergic signalling, in skeletal muscle development and regeneration under the supervision of Professor Geoffrey Burnstock (University College London). Using techniques such as cell culture, RT-PCR and immunohistochemistry, I was able to dissect out the role of an individual signalling pathway. I demonstrated that activation of the P2X5 receptor for ATP potentiated muscle stem cell differentiation and that this process was dependent on activation of the p38 MAP kinase pathway.
Since my PhD the advent of high through-put microarray and sequencing-based technologies have made it possible to take a systems approach and so have the potential to provide exciting insights into complex neurological diseases. With this is in mind I have sought to develop new skills in biomedical informatics and currently hold an MRC Post-doctoral Training Fellowship in Biomedical Informatics. This fellowship has given me the opportunity to pursue my interest in the pathophysiological basis of risk genetic loci for neurodegenerative diseases and that is the focus of my current research.
Page last modified on 20 mar 13 16:49