UK Parkinson's Disease Consortium - UKPDC
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Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...
A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...
Vincent was educated in Paris, France, where he obtained his Bachelor of Mathematics at the Ecole Normale Superieure. He then started working in the field of applied mathematics and statistics and following a MS in Theoretical Probability Theory he started his PhD in Applied Mathematics and Computational Biology at the University of Southern California, Los Angeles, under the supervision of Simon Tavare. Following this PhD he moved in 2006 to the University of Cambridge and the Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory to study the genetics of autoimmune disorders, in particular type 1 diabetes. He then joined the UCL Genetics Institute in October 2009.
Vincent is interested in genetics in a broad sense, with a particular interest for autoimmune disorders. His research interest consists in using genetics data as a tool to investigate the molecular mechanisms underlying complex disorders. To achieve this goal typical tools include gene expression studies, high throughput sequencing of analysis but also analysis of protein data, for example by flow cytometry.esearcherID
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