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John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
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Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials

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Audioslide presentation on Claudia Manzoni's paper examining how fibroblasts with LRRK2 mutations react to starvation conditions and the possible deficits that they have in autophagy.

LRRK2 and autophagy in fibroblasts

In this paper Claudia Manzoni studies how fibroblast cells from people with Parkinson’s disease caused by mutations in LRRK2 react to starvation. Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved – suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles).
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Rohan de Silva

(Reader)

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Born in Sri Lanka, Rohan obtained his degree in Biochemistry in 1987 (Universität Bern, Switzerland) and a D.Phil. in Molecular Biology, 1991 (Oxford University).  From 1991-1995 he worked at Duke University Medical Center, North Carolina (genetics of Alzheimer’s Disease), where he was involved with the first identification of mutations in the presenilin-1 gene and, in collaboration with the late Dr Tsunao Saitoh (UCSD) first identified promoter variants of the alpha-synuclein gene (SNCA) that are now associated with Parkinson’s disease risk. In 1995-1996, he briefly worked at the Marie Curie Research Institute in Oxted, Surrey (genetics of bladder cancer) and 1996-1999 at Imperial College School of Medicine (investigation of role of cytokines in amyloid precursor protein gene expression and splicing). Since 1999 he has been at the RLWI  where he has been working on the genetics, biochemistry and cell biology of Parkinson’s disease, progressive supranuclear palsy and related disorders. His primary interests are the investigation of the tau (MAPT) and SNCA genes and their roles in neurodegeneration.

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