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Poster: Parkinson's and the Genetic Revolution: From Genes to Treatments

Video: Parkinson's and the Genetic Revolution: From Genes to Treatments

Dr Patrick Lewis of University College London and Dr Flaviano Giorgini of the University of Leicester, discuss how their work on genetics is helping us develop treatments for Parkinson's.
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Poster for Autophagy in London public lecture

Public lecture: The autophagy signaling network, c-­‐myc and pathology: don't mess with the cell cycle!

You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...

Link to film: Brain Disease Research - Keeping You You

Video: Brain Disease Research - Keeping You You


Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...

Degenerating Brains public symposium - 13th March 2013

Video: Degenerating Brains public symposium


The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...

Colour-enhanced image of a mitochondrion showing the internal membranes (cristae) and enzyme complexes. Credit Dr David Furness, Wellcome Images.

Mutations in VCP gene implicated in a number of neurodegenerative diseases

New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...


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Gavin Charlesworth

(Clinical Research Fellow)

My initial medical training took place at King’s College London and included an intercalated BSc (Hons) in Neuroscience. After my qualification in 2003, my continued interest in the brain led me to seek posts which would help me secure a place on the specialty training program for neurology, which I succeeded in obtaining in 2008. My predominant interests within the field of neurology are movement disorders, neurodegeneration and genetics and so, when the opportunity to do some research in the genetics of Parkinson’s disease arose, I jumped ship and re-entered the world of science! I am currently a Clinical Research Fellow at the Institute of Neurology where I hope to complete my PhD.


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Number of items: 12.

2013

Charlesworth, G and Bhatia, KP (2013) Primary and secondary dystonic syndromes: an update. Curr Opin Neurol 10.1097/WCO.0b013e3283633696.

Rubio-Agusti, I and Pareés, I and Kojovic, M and Stamelou, M and Saifee, TA and Charlesworth, G and Sheerin, UM and Edwards, MJ and Bhatia, KP (2013) Tremulous cervical dystonia is likely to be familial: Clinical characteristics of a large cohort. Parkinsonism Relat Disord , 19 (6) 634 - 638. 10.1016/j.parkreldis.2013.02.017.

Sheerin, UM and Stamelou, M and Charlesworth, G and Shiner, T and Spacey, S and Valente, EM and Wood, NW and Bhatia, KP (2013) Migraine with aura as the predominant phenotype in a family with a PRRT2 mutation. J Neurol , 260 (2) 656 - 660. 10.1007/s00415-012-6747-4.

2012

Charlesworth, G and Gandhi, S and Bras, JM and Barker, RA and Burn, DJ and Chinnery, PF and Gentleman, SM and Guerreiro, R and Hardy, J and Holton, JL and Lees, A and Morrison, K and Sheerin, UM and Williams, N and Morris, H and Revesz, T and Wood, NW (2012) Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiol Aging , 33 (4) 838.e7 - 838.11. 10.1016/j.neurobiolaging.2011.11.001.

Charlesworth, G and Plagnol, V and Holmström, KM and Bras, J and Sheerin, UM and Preza, E and Rubio-Agusti, I and Ryten, M and Schneider, SA and Stamelou, M and Trabzuni, D and Abramov, AY and Bhatia, KP and Wood, NW (2012) Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. Am J Hum Genet , 91 (6) 1041 - 1050. 10.1016/j.ajhg.2012.10.024.

Charlesworth, G and Wood, NW (2012) Mutations in Nuclear Genes That Affect Mitochondrial Function in Parkinson’s Disease. In: Reeve, AK and Krishnan, KJ and Duchen, M and Turnbull, DM, (eds.) Mitochondrial Dysfunction in Neurodegenerative Disorders. (? - ?). Springer Verlag

Sheerin, UM and Charlesworth, G and Bras, J and Guerreiro, R and Bhatia, K and Foltynie, T and Limousin, P and Silveira-Moriyama, L and Lees, A and Wood, N (2012) Screening for VPS35 mutations in Parkinson's disease. Neurobiol Aging , 33 (4) 838.e1 - 838.e5. 10.1016/j.neurobiolaging.2011.10.032.

Tucci, A and Charlesworth, G and Sheerin, UM and Plagnol, V and Wood, NW and Hardy, J (2012) Study of the genetic variability in a Parkinson's Disease gene: EIF4G1. Neurosci Lett , 518 (1) 19 - 22. 10.1016/j.neulet.2012.04.033.

2011

Nalls, MA and Plagnol, V and Hernandez, DG and Sharma, M and Sheerin, UM and Saad, M and Simon-Sanchez, J and Schulte, C and Lesage, S and Sveinbjornsdottir, S and Arepalli, S and Barker, R and Ben-Shlomo, Y and Berendse, HW and Berg, D and Bhatia, K and de Bie, RMA and Biffi, A and Bloem, B and Bochdanovits, Z and Bonin, M and Bras, JM and Brockmann, K and Brooks, J and Burn, DJ and Charlesworth, G and Chen, HL and Chinnery, PF and Chong, S and Clarke, CE and Cookson, MR and Cooper, JM and Corvol, JC and Counsell, C and Damier, P and Dartigues, JF and Deloukas, P and Deuschl, G and Dexter, DT and van Dijk, KD and Dillman, A and Durif, F and Durr, A and Edkins, S and Evans, JR and Foltynie, T and Gao, JJ and Gardner, M and Gibbs, JR and Goate, A and Gray, E and Guerreiro, R and Gustafsson, O and Harris, C and van Hilten, JJ and Hofman, A and Hollenbeck, A and Holton, J and Hu, M and Huang, XM and Huber, H and Hudson, G and Hunt, SE and Huttenlocher, J and Illig, T and Jonsson, PV and Lambert, JC and Langford, C and Lees, A and Lichtner, P and Limousin, P and Lopez, G and Lorenz, D and McNeill, A and Moorby, C and Moore, M and Morris, HR and Morrison, KE and Mudanohwo, E and O'Sullivan, SS and Pearson, J and Perlmutter, JS and Petursson, H and Pollak, P and Post, B and Potter, S and Ravina, B and Revesz, T and Riess, O and Rivadeneira, F and Rizzu, P and Ryten, M and Sawcer, S and Schapira, A and Scheffer, H and Shaw, K and Shoulson, I and Sidransky, E and Smith, C and Spencer, CCA and Stefansson, H and Stockton, JD and Strange, A and Talbot, K and Tanner, CM and Tashakkori-Ghanbaria, A and Tison, F and Trabzuni, D and Traynor, BJ and Uitterlinden, AG and Velseboer, D and Vidailhet, M and Walker, R and van de Warrenburg, B and Wickremaratchi, M and Williams, N and Williams-Gray, CH and Winder-Rhodes, S and Stefansson, K and Martinez, M and Hardy, J and Heutink, P and Brice, A and Gasser, T and Singleton, AB and Wood, NW and Int Parkinson Dis Genomics Consort, and Wellcome Trust Case-Control Consor, (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. LANCET , 377 (9766) 641 - 649. 10.1016/S0140-6736(10)62345-8.

Plagnol, V and Nalls, MA and Bras, JM and Hernandez, DG and Sharma, M and Sheerin, UM and Saad, M and Simon-Sanchez, J and Schulte, C and Lesage, S and Sveinbjornsdottir, S and Amouyel, P and Arepalli, S and Band, G and Barker, RA and Bellinguez, C and Ben-Shlomo, Y and Berendse, HW and Berg, D and Bhatia, K and de Bie, RMA and Biffi, A and Bloem, B and Bochdanovits, Z and Bonin, M and Brockmann, K and Brooks, J and Burn, DJ and Charlesworth, G and Chen, HL and Chinnery, PF and Chong, S and Clarke, CE and Cookson, MR and Cooper, JM and Corvol, JC and Counsell, C and Damier, P and Dartigues, JF and Deloukas, P and Deuschl, G and Dexter, DT and van Dijk, KD and Dillman, A and Durif, F and Durr, A and Edkins, S and Evans, JR and Foltynie, T and Freeman, C and Gao, JJ and Gardner, M and Gibbs, JR and Goate, A and Gray, E and Guerreiro, R and Gustafsson, O and Harris, C and Hellenthal, G and van Hilten, JJ and Hofman, A and Hollenbeck, A and Holton, J and Hu, M and Huang, XM and Huber, H and Hudson, G and Hunt, SE and Huttenlocher, J and Illig, T and Jonsson, PV and Langford, C and Lees, A and Lichtner, P and Limousin, P and Lopez, G and Lorenz, D and McNeill, A and Moorby, C and Moore, M and Morris, H and Morrison, KE and Mudanohwo, E and O'Sullivan, SS and Pearson, J and Pearson, R and Perlmutter, JS and Petursson, H and Pirinen, M and Pollak, P and Post, B and Potter, S and Ravina, B and Revesz, T and Riess, O and Rivadeneira, F and Rizzu, P and Ryten, M and Sawcer, S and Schapira, A and Scheffer, H and Shaw, K and Shoulson, I and Sidransky, E and de Silva, R and Smith, C and Spencer, CCA and Stefansson, H and Steinberg, S and Stockton, JD and Strange, A and Su, Z and Talbot, K and Tanner, CM and Tashakkori-Ghanbaria, A and Tison, F and Trabzuni, D and Traynor, BJ and Uitterlinden, AG and Vandrovcova, J and Velseboer, D and Vidailhet, M and Vukcevic, D and Walker, R and van de Warrenburg, B and Weale, ME and Wickremaratchi, M and Williams, N and Williams-Gray, CH and Winder-Rhodes, S and Stefansson, K and Martinez, M and Donnelly, P and Singleton, AB and Hardy, J and Heutink, P and Brice, A and Gasser, T and Wood, NW and WTCCC2, (2011) A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease. PLOS GENET , 7 (6) , Article e1002142. 10.1371/journal.pgen.1002142.
An open access publication

2009

Charlesworth, G and Soryal, I and Smith, S and Sisodiya, SM (2009) Acute, localised paroxysmal pain as the initial manifestation of focal seizures: A case report and a brief review of the literature. PAIN , 141 (3) 300 - 305. 10.1016/j.pain.2008.11.005.

2005

Docherty, RJ and Charlesworth, G and Farrag, K and Bhattacharjee, A and Costa, S (2005) The use of the rat isolated vagus nerve for functional measurements of the effect of drugs in vitro. J Pharmacol Toxicol Methods , 51 (3) 235 - 242. 10.1016/j.vascn.2004.08.011.

This list was generated on Wed Jun 19 00:37:11 2013 BST.

Page last modified on 19 mar 13 16:35