UK Parkinson's Disease Consortium - UKPDC
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Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
You are invited to an evening (13th March 2013) exploring the very latest in cutting edge research into neurodegenerative diseases. Supported by the Wellcome Trust, scientists investigating Alzheimer's, Parkinson's and Motor Neuron disease will explain how our understanding of these disorders is changing in the light of new discoveries in genetics and cell biology, and how these discoveries impact on developing new drugs for these diseases.
18.00 Welcome and introduction
18.10 Lectures commence
(Senior Postdoctoral Research Fellow)
My interest in studying basic molecular and biochemical pathways and their dysregulation in disease has been the driving force behind the progression of my scientific career. I graduated from Edinburgh University in 2000 with a BSc Hons in Developmental Biology and was selected to undertake a PhD within the laboratory of Professor Pascal Meier at the prestigious Toby Robins Breakthrough Breast Cancer centre within the Institute of Cancer Research, London. My PhD studies focused on apoptosis pathways, specifically mechanisms of caspase activation using Drosophila melanogaster as a model organism and translating the findings into mammalian studies. During this work I identified a novel kinase involved in caspase activation. After graduating with my PhD in 2005, I undertook a short postdoctoral appointment at the School of Pharmacy in Professor Robert Harvey’s laboratory studying the Parkinson’s Disease (PD) related protein kinase PINK1. I was subsequently hired by Professor Nicholas W Wood at the UCL Institute of Neurology in 2007 to continue these studies using mammalian cell systems. I am currently a senior postdoctoral researcher employed under a strategic award from the MRC/Wellcome trust to investigate the underlying mechanisms of PD and aim to establish my own laboratory within the Institute of Neurology in the near future. At present Dr Deas supervises BSc and clinical MSc students in addition to aiding in PhD student supervision. Postdoctoral appointments under Dr Deas are currently under consideration with the relevant funding bodies
|Link to Publications|
|Duran, R and Mencacci, NE and Angeli, AV and Shoai, M and Deas, E and Houlden, H and Mehta, A and Hughes, D and Cox, TM and Deegan, P and Schapira, AH and Lees, AJ and Limousin, P and Jarman, PR and Bhatia, KP and Wood, NW and Hardy, J and Foltynie, T (2013) The glucocerobrosidase E326K variant predisposes to Parkinson's disease, but does not cause Gaucher's disease. Mov Disord , 28 (2) 232 - 236. 10.1002/mds.25248. |
|Siddall, HK and Yellon, DM and Ong, SB and Mukherjee, UA and Burke, N and Hall, AR and Angelova, PR and Ludtmann, MH and Deas, E and Davidson, SM and Mocanu, MM and Hausenloy, DJ (2013) Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury. PLoS One , 8 (4) e62400 - ?. 10.1371/journal.pone.0062400. |
|Wood-Kaczmar, A and Deas, E and Wood, NW and Abramov, AY (2013) The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Adv Exp Med Biol , 961 241 - 249. 10.1007/978-1-4614-4756-6_20. |
|Cremades, N and Cohen, SI and Deas, E and Abramov, AY and Chen, AY and Orte, A and Sandal, M and Clarke, RW and Dunne, P and Aprile, FA and Bertoncini, CW and Wood, NW and Knowles, TP and Dobson, CM and Klenerman, D (2012) Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell , 149 (5) 1048 - 1059. 10.1016/j.cell.2012.03.037. |
|Pimenta de Castro, I and Costa, AC and Lam, D and Tufi, R and Fedele, V and Moisoi, N and Dinsdale, D and Deas, E and Loh, SH and Martins, LM (2012) Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. Cell Death Differ , 19 (8) 1308 - 1316. 10.1038/cdd.2012.5. |
|Plun-Favreau, H and Burchell, VS and Holmström, KM and Yao, Z and Deas, E and Cain, K and Fedele, V and Moisoi, N and Campanella, M and Miguel Martins, L and Wood, NW and Gourine, AV and Abramov, AY (2012) HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion. Cell Death Dis , 3 e335 - ?. 10.1038/cddis.2012.77. |
|Deas, E and Plun-Favreau, H and Gandhi, S and Desmond, H and Kjaer, S and Loh, SHY and Renton, AEM and Harvey, RJ and Whitworth, AJ and Martins, LM and Abramov, AY and Wood, NW (2011) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Human Molecular Genetics , 20 (5) pp. 867-879. 10.1093/hmg/ddq526. |
|Deas, E and Wood, NW and Plun-Favreau, H (2011) Mitophagy and Parkinson's disease: The PINK1-parkin link. BBA-MOL CELL RES , 1813 (4) 623 - 633. 10.1016/j.bbamcr.2010.08.007. |
|Burchell, VS and Gandhi, S and Deas, E and Wood, NW and Abramov, AY and Plun-Favreau, H (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part II. EXPERT OPIN THER TAR , 14 (5) 497 - 511. 10.1517/14728221003730434. |
|Burchell, VS and Gandhi, S and Deas, E and Wood, NW and Abramov, AY and Plun-Favreau, H (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. EXPERT OPIN THER TAR , 14 (4) 369 - 385. 10.1517/14728221003652489. |
|Deas, E and Dunn, L (2010) Unraveling LRRK2 Pathogenesis: Common Pathways for Complex Genes? J NEUROSCI , 30 (5) 1577 - 1579. 10.1523/JNEUROSCI.5531-09.2010. |
|Deas, E and Plun-Favreau, H and Wood, NW (2009) PINK1 function in health and disease. EMBO MOL MED , 1 (3) 152 - 165. 10.1002/emmm.200900024. |
|Gandhi, S and Wood-Kaczmar, A and Yao, Z and Plun-Favreau, H and Deas, E and Klupsch, K and Downward, J and Latchman, DS and Tabrizi, SJ and Wood, NW and Duchen, MR and Abramov, AY (2009) PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death. MOL CELL , 33 (5) 627 - 638. 10.1016/j.molcel.2009.02.013. |
|Kalscheuer, VM and Musante, L and Fang, C and Hoffmann, K and Fuchs, C and Carta, E and Deas, E and Venkateswarlu, K and Menzel, C and Ullmann, R and Tommerup, N and Dalpra, L and Tzschach, A and Selicorni, A and Luscher, B and Ropers, HH and Harvey, K and Harvey, RJ (2009) A Balanced Chromosomal Translocation Disrupting ARHGEF9 Is Associated With Epilepsy, Anxiety, Aggression, and Mental Retardation. HUM MUTAT , 30 (1) 61 - 68. 10.1002/humu.20814. |
|Neumann, J and Bras, J and Deas, E and O'Sullivan, SS and Parkkinen, L and Lachmann, RH and Li, A and Holton, J and Guerreiro, R and Paudel, R and Segarane, B and Singleton, A and Lees, A and Hardy, J and Houlden, H and Revesz, T and Wood, NW (2009) Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. BRAIN , 132 1783 - 1794. 10.1093/brain/awp044. |
|Neumann, J and Parkkinen, L and Bras, J and O'sullivan, SS and Deas, E and Lachmann, H and Li, A and Holton, L and Guerreiro, R and Paudel, R and Segarane, B and Singleton, A and Lees, A and Hardy, J and Houlden, H and Revesz, T and Wood, NW (2009) Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. In: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. (pp. 3 - 3). BLACKWELL PUBLISHING |
|Plun-Favreau, H and Gandhi, S and Wood-Kaczmar, A and Deas, E and Yao, Z and Wood, NW (2008) What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease? MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS , 1147 30 - 36. 10.1196/annals.1427.032. |
|Wood-Kaczmar, A and Gandhi, S and Yao, Z and Abramov, ASY and Miljan, EA and Keen, G and Stanyer, L and Hargreaves, I and Klupsch, K and Deas, E and Downward, J and Mansfield, L and Jat, P and Taylor, J and Heales, S and Duchen, MR and Latchman, D and Tabrizi, SJ and Wood, NW (2008) PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons. PLOS ONE , 3 (6) , Article e2455. 10.1371/journal.pone.0002455. |
|Plun-Favreau, H and Klupsch, K and Moisoi, N and Gandhi, S and Kjaer, S and Frith, D and Harvey, K and Deas, E and Harvey, RJ and McDonald, N and Wood, NW and Martins, LM and Downward, J (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. NAT CELL BIOL , 9 (11) 1243 - U63. 10.1038/ncb1644. |
|Abou-Sleiman, PM and Muqit, MMK and McDonald, NQ and Yang, YX and Gandhi, S and Healy, DG and Harvey, K and Harvey, RJ and Deas, E and Hatia, K and Quinn, N and Lees, A and Latchman, DS and Wood, NW (2006) A heterozygous effect for PINK1 mutations in Parkinson's disease? ANN NEUROL , 60 (4) 414 - 419. 10.1002/ana.20960. |
|Muqit, MM and Gandhi, S and Deas, E and Abou-Sleiman, PM and Harvey, K and Harvey, RJ and Wood, NW and Latchman, DS (2006) A site-directed mutagenesis study of putative cleavage sites of the Parkinson's disease associated gene, PINK1. In: MOVEMENT DISORDERS. (pp. S560 - S560). WILEY-LISS |
|Muqit, MMK and Abou-Sleiman, PM and Saurin, AT and Harvey, K and Gandhi, S and Deas, E and Eaton, S and Smith, MDP and Venner, K and Matilla, A and Healy, DG and Gilks, WP and Lees, AJ and Holton, J and Revesz, T and Parker, PJ and Harvey, RJ and Wood, NW and Latchman, DS (2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J NEUROCHEM , 98 (1) 156 - 169. 10.1111/j.1471-4159.2006.03845.x. |
|Ditzel, M and Wilson, R and Tenev, T and Zachariou, A and Paul, A and Deas, E and Meier, P (2003) Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. NAT CELL BIOL , 5 (5) 467 - 473. 10.1038/ncb984. |
Page last modified on 19 mar 13 16:57