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Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
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Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials

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Audioslide presentation on Claudia Manzoni's paper examining how fibroblasts with LRRK2 mutations react to starvation conditions and the possible deficits that they have in autophagy.

LRRK2 and autophagy in fibroblasts

In this paper Claudia Manzoni studies how fibroblast cells from people with Parkinson’s disease caused by mutations in LRRK2 react to starvation. Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved – suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles).
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Drosophila fly model - University of Sheffield

Genetic mutations linked to Parkinson's disease

Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...

Autophagy

LRRK2 and autophagy

Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Here, Claudia Manzoni talks about her research (funded by the Rosetrees Trust and the Michael J. Fox Foundation) into what LRRK2 might be doing within the cell: Parkinson’s disease is a brain illness that afflicts 1 in 500 people in the UK. High profile patients, such as the actor Michael J Fox, the boxer Muhammad Ali and the late Pope John Paul II, have raised public awareness of Parkinson’s and its devastating impact. More...

Andrey Abramov

(Co-Investigator)

Andrey Abramov


I obtained my PhD in Biophysics from Tashkent State University. Mitochondria, reactive oxygen species (ROS) production and calcium signaling have been my main research focus since my PhD.

I originally focused on unraveling of the mechanisms of neurodegeneration in Alzheimer`s disease, excitotoxicity and ischeamic damage during my work as a Postdoctoral Fellow in the Department of Physiology, University College London.

I joined the Department of Molecular Neuroscience, UCL Institute of Neurology in 2008, then I was awarded a Senior Research Fellowship from Parkinson`s UK.


Contact details


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Number of items: 98.

2014

Angelova, PR; Agrawalla, BK; Elustondo, PA; Gordon, J; Shiba, T; Abramov, AY; ... Pavlov, EV; + view all (2014) In-situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8. ACS Chem Biol 10.1021/cb5000696.

Deas, E; Piipari, K; Machhada, A; Li, A; Gutierrez-del-Arroyo, A; Withers, DJ; ... Abramov, AY; + view all (2014) PINK1 deficiency in b-cells increases basal insulin secretion and improves glucose tolerance in mice. Open Biol , 4 (5) 140051 - ?.

Deas, E; Piipari, K; Machhada, A; Li, A; Gutierrez-Del-Arroyo, A; Withers, DJ; ... Abramov, AY; + view all (2014) PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice. Open Biol , 4 (5) 140051 - ?. 10.1098/rsob.140051.

Duberley, KE; Heales, SJ; Abramov, AY; Chalasani, A; Land, JM; Rahman, S; Hargreaves, IP; (2014) Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in coenzyme Q10 deficient human neuronal cells. Int J Biochem Cell Biol 10.1016/j.biocel.2014.02.003.

McNeill, A; Magalhaes, J; Shen, C; Chau, KY; Hughes, D; Mehta, A; ... Schapira, AH; + view all (2014) Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain , 137 (5) pp. 1481-1495. 10.1093/brain/awu020. Green and gold open access
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Narayan, P; Holmström, KM; Kim, DH; Whitcomb, DJ; Wilson, MR; St George-Hyslop, P; ... Klenerman, D; + view all (2014) Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage. Biochemistry 10.1021/bi401606f.

Neary, MT; Ng, KE; Ludtmann, MH; Hall, AR; Piotrowska, I; Ong, SB; ... Breckenridge, RA; + view all (2014) Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function. J Mol Cell Cardiol 10.1016/j.yjmcc.2014.06.013.

Tufi, R; Gandhi, S; de Castro, IP; Lehmann, S; Angelova, PR; Dinsdale, D; ... Martins, LM; + view all (2014) Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol 10.1038/ncb2901.

2013

Abramov, AY; (2013) ROLE OF ASTROCYTE SIGNALLING IN THE NEUROTOXICITY OF beta-AMYOID: ROLES OF ASTROCYTES IN NEURONAL DEATH IN ALZHEIMER'S DISEASE? In: GLIA. (pp. S39 - S39).

Baev, AY; Holmstrom, KM; Levitskaya, YV; Abramov, AY; (2013) Role of Polyphosphate in Mitochondria: From Modification of Energy Metabolism to Induction of the Cell Death. In: BIOPHYSICAL JOURNAL. (pp. 660A - 660A).

Bartolome, F; Wu, HC; Burchell, VS; Preza, E; Wray, S; Mahoney, CJ; ... Plun-Favreau, H; + view all (2013) Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels. Neuron , 78 (1) 57 - 64. 10.1016/j.neuron.2013.02.028. Green and gold open access
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Bobkova, NV; Medvinskaya, NI; Kamynina, AN; Aleksandrova, IY; Nesterova, IV; Samokhin, AV; ... Volpina, OM; + view all (2013) Immunization with either prion protein fragment 95-123 or the fragment-specific antibodies rescue memory loss and neurodegenerative phenotype of neurons in olfactory bulbectomized mice. Neurobiol Learn Mem 10.1016/j.nlm.2013.10.019.

Breckenridge, RA; Piotrowska, I; Ng, KE; Ragan, TJ; West, JA; Kotecha, S; ... Mohun, TJ; + view all (2013) Correction: Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism. PLoS Biol , 11 (12) 10.1371/annotation/a9a7f37a-3fa7-4f7f-8310-1339bf5a666e.

Breckenridge, RA; Piotrowska, I; Ng, KE; Ragan, TJ; West, JA; Kotecha, S; ... Mohun, TJ; + view all (2013) Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism. PLoS Biol , 11 (9) e1001666 - ?. 10.1371/journal.pbio.1001666.

Burchell, VS; Nelson, DE; Sanchez-Martinez, A; Delgado-Camprubi, M; Ivatt, RM; Pogson, JH; ... Plun-Favreau, H; + view all (2013) The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci 10.1038/nn.3489.

Domijan, AM; Kovac, S; Abramov, AY; (2013) Lipid peroxidation is essential for phospholipase C activity and IP3 related calcium signal. J Cell Sci 10.1242/jcs.138370.

Duberley, KE; Abramov, AY; Chalasani, A; Heales, SJ; Rahman, S; Hargreaves, IP; (2013) Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. J Inherit Metab Dis , 36 (1) 63 - 73. 10.1007/s10545-012-9511-0.

Elustondo, PA; Angelova, PR; Kawalec, M; Michalak, M; Kurcok, P; Abramov, AY; Pavlov, EV; (2013) Polyhydroxybutyrate Targets Mammalian Mitochondria and Increases Permeability of Plasmalemmal and Mitochondrial Membranes. PLoS One , 8 (9) , Article e75812. 10.1371/journal.pone.0075812. Green and gold open access
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Fitzgerald, JC; Ugun-Klusek, A; Allen, G; De Girolamo, LA; Hargreaves, I; Ufer, C; ... Billett, EE; + view all (2013) Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins. FASEB J 10.1096/fj.13-235481.

Holmström, KM; Baird, L; Zhang, Y; Hargreaves, I; Chalasani, A; Land, JM; ... Abramov, AY; + view all (2013) Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biology Open , 2 761 - 770. 10.1242/bio.20134853. Green and gold open access
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Holmström, KM; Marina, N; Baev, AY; Wood, NW; Gourine, AV; Abramov, AY; (2013) Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun , 4 1362 - ?. 10.1038/ncomms2364. Gold open access

Kamynina, AV; Filatova, MP; Koroev, DO; Abramov, AY; Volpina, OM; (2013) Antibodies to synthetic fragment 95-123 of the prion protein protect neurons and astrocytes from beta-amyloid toxicity. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY , 39 (2) 113 - 120. 10.1134/S1068162013020076.

Kamynina, AV; Holmström, KM; Koroev, DO; Volpina, OM; Abramov, AY; (2013) Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity. Int J Biochem Cell Biol , 45 (4) 899 - 907. 10.1016/j.biocel.2013.01.011.

Kovac, S; Abramov, AY; Walker, MC; (2013) Energy depletion in seizures: anaplerosis as a strategy for future therapies. Neuropharmacology , 69 96 - 104. 10.1016/j.neuropharm.2012.05.012.

Ludtmann, MH; Angelova, PR; Zhang, Y; Abramov, AY; Dinkova-Kostova, AT; (2013) Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation. Biochem J 10.1042/BJ20130863.

Smithen, M; Elustondo, PA; Winkfein, R; Zakharian, E; Abramov, AY; Pavlov, E; (2013) Role of polyhydroxybutyrate in mitochondrial calcium uptake. Cell Calcium 10.1016/j.ceca.2013.04.006.

Suwanjang, W; Abramov, AY; Govitrapong, P; Chetsawang, B; (2013) Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells. J Steroid Biochem Mol Biol 10.1016/j.jsbmb.2013.04.008.

Suwanjang, W; Holmström, KM; Chetsawang, B; Abramov, AY; (2013) Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity. Cell Calcium , 53 (4) 256 - 263. 10.1016/j.ceca.2012.12.006.

Tucci, A; Liu, YT; Preza, E; Pitceathly, RD; Chalasani, A; Plagnol, V; ... Houlden, H; + view all (2013) Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy. Journal of Neurology, Neurosurgery & Psychiatry 10.1136/jnnp-2013-306387. Green and gold open access
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Vaarmann, A; Kovac, S; Holmström, KM; Gandhi, S; Abramov, AY; (2013) Dopamine protects neurons against glutamate-induced excitotoxicity. Cell Death Dis , 4 , Article e455 . 10.1038/cddis.2012.194. Green and gold open access
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Wood-Kaczmar, A; Deas, E; Wood, NW; Abramov, AY; (2013) The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Adv Exp Med Biol , 961 241 - 249. 10.1007/978-1-4614-4756-6_20.

2012

Charlesworth, G; Plagnol, V; Holmström, KM; Bras, J; Sheerin, UM; Preza, E; ... Wood, NW; + view all (2012) Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. The American Journal of Human Genetics , 91 (6) 1041 - 1050. 10.1016/j.ajhg.2012.10.024. Green and gold open access
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Cremades, N; Cohen, SI; Deas, E; Abramov, AY; Chen, AY; Orte, A; ... Klenerman, D; + view all (2012) Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell , 149 (5) 1048 - 1059. 10.1016/j.cell.2012.03.037.

Ding, S; Riddoch-Contreras, J; Abramov, AY; Qi, Z; Duchen, MR; (2012) Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide. J Muscle Res Cell Motil , 33 (5) 339 - ?. 10.1007/s10974-012-9327-4.

Ding, S; Riddoch-Contreras, J; Abramov, AY; Qi, Z; Duchen, MR; (2012) Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide. J Muscle Res Cell Motil , 33 (5) 327 - 337. 10.1007/s10974-012-9318-5.

Domijan, AM; Kovac, S; Abramov, AY; (2012) Impact of fumonisin B1 on glutamate toxicity and low magnesium-induced seizure activity in neuronal primary culture. Neuroscience , 202 10 - 16. 10.1016/j.neuroscience.2011.12.005.

Gandhi, S; Abramov, AY; (2012) Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev , 2012 428010 - ?. 10.1155/2012/428010. Gold open access

Gandhi, S; Vaarmann, A; Yao, Z; Duchen, MR; Wood, NW; Abramov, AY; (2012) Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PLoS One , 7 (5) , Article e37564 . 10.1371/journal.pone.0037564. Green and gold open access
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Holmstrom, KM; Baird, L; Dinkova-Kostova, AT; Abramov, AY; (2012) Nrf2 Controls Mitochondrial Bioenergetics. BIOPHYSICAL JOURNAL , 102 (3) 573A - 573A.

Kamynina, AV; Holmstrom, KM; Koroev, DO; Volpina, OM; Abramov, AY; (2012) Anti-peptide antibodies to synthetic fragments of alpha7-subunit acetylcholine receptor or prion protein protect cells against beta-amyloid toxicity. JOURNAL OF PEPTIDE SCIENCE , 18 S136 - S136.

Kovac, S; Domijan, AM; Walker, MC; Abramov, AY; (2012) Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death. J Cell Sci , 125 (Pt 7) 1796 - 1806. 10.1242/jcs.099176.

Plun-Favreau, H; Burchell, VS; Holmström, KM; Yao, Z; Deas, E; Cain, K; ... Abramov, AY; + view all (2012) HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion. Cell Death and Disease , 3 , Article e335. 10.1038/cddis.2012.77. Green and gold open access
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2011

Abeti, R; Abramov, AY; Duchen, MR; (2011) beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. BRAIN , 134 1658 - 1672. 10.1093/brain/awr104.

Abramov, AY; Duchen, MR; (2011) Measurements of threshold of mitochondrial permeability transition pore opening in intact and permeabilized cells by flash photolysis of caged calcium. Methods Mol Biol , 793 299 - 309. 10.1007/978-1-61779-328-8_19.

Abramov, AY; Gegg, M; Grunewald, A; Wood, NW; Klein, C; Schapira, AHV; (2011) Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease. PLOS ONE , 6 (10) , Article e25622. 10.1371/journal.pone.0025622. Green and gold open access
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Abramov, AY; Ionov, M; Pavlov, E; Duchen, MR; (2011) Membrane cholesterol content plays a key role in the neurotoxicity of beta-amyloid: implications for Alzheimer's disease. AGING CELL , 10 (4) 595 - 603. 10.1111/j.1474-9726.2011.00685.x.

Deas, E; Plun-Favreau, H; Gandhi, S; Desmond, H; Kjaer, S; Loh, SHY; ... Wood, NW; + view all (2011) PINK1 cleavage at position A103 by the mitochondrial protease PARL. Human Molecular Genetics , 20 (5) pp. 867-879. 10.1093/hmg/ddq526. Green open access
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Domijan, AM; Abramov, AY; (2011) Fumonisin B-1 inhibits mitochondrial respiration and deregulates calcium homeostasis-Implication to mechanism of cell toxicity. INT J BIOCHEM CELL B , 43 (6) 897 - 904. 10.1016/j.biocel.2011.03.003.

Ionov, M; Burchell, V; Klajnert, B; Bryszewska, M; Abramov, AY; (2011) MECHANISM OF NEUROPROTECTION OF MELATONIN AGAINST BETA-AMYLOID NEUROTOXICITY. NEUROSCIENCE , 180 229 - 237. 10.1016/j.neuroscience.2011.02.045.

Kovac, S; Domijan, A; Walker, MC; Abramov, AY; (2011) PROLONGED SEIZURE ACTIVITY IMPAIRS MITOCHONDRIAL BIOENERGETICS AND INDUCES CELL DEATH. In: EPILEPSIA. (pp. 85 - 85). WILEY-BLACKWELL

Kovac, S; Domijan, AM; Walker, MC; Abramov, AY; (2011) ROLE OF MITOCHONDRIAL FUNCTION IN SEIZURE-INDUCED NEURONAL CELL DEATH. In: EPILEPSIA. (pp. 45 - 45). WILEY-BLACKWELL

Yao, Z; Gandhi, S; Burchell, VS; Plun-Favreau, H; Wood, NW; Abramov, AY; (2011) Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci , 124 (Pt 24) 4194 - 4202. 10.1242/jcs.088260. Gold open access

2010

Abramov, AY; Duchen, MR; (2010) Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS , 1800 (3) 297 - 304. 10.1016/j.bbagen.2009.08.002.

Abramov, AY; Smulders-Srinivasan, TK; Kirby, DM; Acin-Perez, R; Enriquez, JA; Lightowlers, RN; ... Turnbull, DM; + view all (2010) Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations. BRAIN , 133 797 - 807. 10.1093/brain/awq015.

Ahluwalia, J; Tinker, A; Clapp, LH; Duchen, MR; Abramov, AY; Pope, S; ... Segal, AW; + view all (2010) The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retraction of vol 427, pg 853, 2004). NATURE , 468 (7320) 122 - 122. 10.1038/nature09562.

Burchell, VS; Gandhi, S; Deas, E; Wood, NW; Abramov, AY; Plun-Favreau, H; (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part II. EXPERT OPIN THER TAR , 14 (5) 497 - 511. 10.1517/14728221003730434.

Burchell, VS; Gandhi, S; Deas, E; Wood, NW; Abramov, AY; Plun-Favreau, H; (2010) Targeting mitochondrial dysfunction in neurodegenerative disease: Part I. EXPERT OPIN THER TAR , 14 (4) 369 - 385. 10.1517/14728221003652489.

Igosheva, N; Abramov, AY; Poston, L; Eckert, JJ; Fleming, TP; Duchen, MR; McConnell, J; (2010) Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes. PLOS ONE , 5 (4) , Article e10074. 10.1371/journal.pone.0010074. Green and gold open access
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Pavlov, E; Aschar-Sobbi, R; Campanella, M; Turner, RJ; Gomez-Garcia, MR; Abramov, AY; (2010) Inorganic Polyphosphate and Energy Metabolism in Mammalian Cells. J BIOL CHEM , 285 (13) 9420 - 9428. 10.1074/jbc.M109.013011. Gold open access

Vaarmann, A; Gandhi, S; Abramov, AY; (2010) Dopamine Induces Ca2+ Signaling in Astrocytes through Reactive Oxygen Species Generated by Monoamine Oxidase. J BIOL CHEM , 285 (32) 25018 - 25023. 10.1074/jbc.M110.111450. Gold open access

Vaarmann, A; Gandhi, S; Gourine, AV; Abramov, AY; (2010) Novel pathway for an old neurotransmitter: Dopamine-induced neuronal calcium signalling via receptor-independent mechanisms. CELL CALCIUM , 48 (2-3) 176 - 182. 10.1016/j.ceca.2010.08.008.

Yao, Z; Gandhi, S; Plun-Favreau, H; Wood, NW; Abramov, AY; (2010) PINK1 Deficiency and Mitochondrial Dysfunction in Neurons and Skeletal Myocytes. BIOPHYSICAL JOURNAL , 98 (3) 381A - 381A.

2009

Cantley, J; Selman, C; Shukla, D; Abramov, AY; Forstreuter, F; Esteban, MA; ... Withers, DJ; + view all (2009) Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J CLIN INVEST , 119 (1) 125 - 135. 10.1172/JCI26934.

Galkin, A; Abramov, AY; Frakich, N; Duchen, MR; Moncada, S; (2009) Lack of Oxygen Deactivates Mitochondrial Complex I IMPLICATIONS FOR ISCHEMIC INJURY? J BIOL CHEM , 284 (52) 36055 - 36061. 10.1074/jbc.M109.054346. Gold open access

Gandhi, S; Wood-Kaczmar, A; Wood, NW; Duchen, MR; Abramov, AY; (2009) PINK1 associated Parkinson's disease is caused by neuronal vulnerability to calcium induced cell death. In: MOVEMENT DISORDERS. (pp. S33 - S33). WILEY-LISS

Gandhi, S; Wood-Kaczmar, A; Yao, Z; Plun-Favreau, H; Deas, E; Klupsch, K; ... Abramov, AY; + view all (2009) PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death. MOL CELL , 33 (5) 627 - 638. 10.1016/j.molcel.2009.02.013. Gold open access

Wood-Kaczmar, A; Gandhi, S; Yao, Z; Abramov, AY; Miljan, EA; Keen, G; ... Wood, NW; + view all (2009) PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons. In: JOURNAL OF NEUROCHEMISTRY. (pp. 301 - 302). WILEY-BLACKWELL PUBLISHING, INC

2008

Abramov, AY; Duchen, MR; (2008) Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS , 1777 (7-8) 953 - 964. 10.1016/j.bbabio.2008.04.017.

Abramov, AY; Kasymov, VA; Zinchenko, VP; (2008) Beta amyloid activates synthesis of nitric oxide in hyppocampal astrocytes and causes death of neurons. BIOL MEMBRANY , 25 (1) 11 - 17.

Aschar-Sobbi, R; Abramov, AY; Diao, C; Kargacin, ME; Kargacin, GJ; French, RJ; Pavlov, E; (2008) High sensitivity, quantitative measurements of polyphosphate using a new DAPI-Based approach. J FLUORESC , 18 (5) 859 - 866. 10.1007/s10895-008-0315-4.

Campanella, M; Casswell, E; Chong, S; Farah, Z; Wieckowski, MR; Abramov, AY; ... Duchen, MR; + view all (2008) Regulation of mitochondrial structure and function by the F1FO-ATPase inhibitor protein, IF1. CELL METAB , 8 (1) 13 - 25. 10.1016/j.cmet.2008.06.001.

Wood-Kaczmar, A; Gandhi, S; Yao, Z; Abramov, ASY; Miljan, EA; Keen, G; ... Wood, NW; + view all (2008) PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons. PLOS ONE , 3 (6) , Article e2455. 10.1371/journal.pone.0002455. Green and gold open access
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2007

Abramov, A.Y.; Scorziello, A.; Duchen, M.R.; (2007) Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. Journal of Neuroscience , 27 (5) pp. 1129-1138. 10.1523/JNEUROSCI.4468-06.2007. Green open access
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Abramov, AY; Fraley, C; Diao, CT; Winkfein, R; Colicos, MA; Duchen, MR; ... Pavlov, E; + view all (2007) Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death. P NATL ACAD SCI USA , 104 (46) 18091 - 18096. 10.1073/pnas.0708959104. Gold open access

Abramov, AY; Scorziello, A; Duchen, MR; (2007) Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J NEUROSCI , 27 (5) 1129 - 1138. 10.1523/JNEUROSCI.4468-06.2007.

2005

Abramov, A.Y.; Jacobson, J.; Wientjes, F.; Hothersall, J.; Canevari, L.; Duchen, M.R.; (2005) Expression and modulation of an NADPH oxidase in mammalian astrocytes. Journal of Neuroscience , 25 (40) pp. 9176-9184. 10.1523/JNEUROSCI.1632-05.2005. Green open access
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Abramov, AY; Canevari, L; Duchen, MR; (2005) Expression, function and modulation of an NADPH oxidase in mammalian astrocytes. In: BIOPHYSICAL JOURNAL. (pp. 256A - 257A). BIOPHYSICAL SOCIETY

Abramov, AY; Duchen, MR; (2005) The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES , 360 (1464) 2309 - 2314. 10.1098/rstb.2005.1766. Gold open access

Abramov, AY; Duchen, MR; (2005) Mechanisms underlying the loss of mitochondrial potential calcium homeostasis in neurons during glutamate excitotoxicity. In: JOURNAL OF NEUROCHEMISTRY. (pp. 246 - 246).

Abramov, AY; Jacobson, J; Wientjes, F; Hothersall, J; Canevari, L; Duchen, MR; (2005) Expression and modulation of an NADPH oxidase in mammalian astrocytes. J NEUROSCI , 25 (40) 9176 - 9184. 10.1523/JNEUROSCI.1632-05.2005.

2004

Abramov, A.Y.; Canevari, L.; Duchen, M.R.; (2004) β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. Journal of Neuroscience , 24 (2) pp. 565-575. 10.1523/JNEUROSCI.4042-03.2004. Green open access
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Abramov, AY; Canevari, L; Duchen, MR; (2004) Calcium signals induced by amylold beta peptide and their consequences in neurons and astrocytes in culture. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH , 1742 (1-3) 81 - 87. 10.1016/j.bbamcr.2004.09.006.

Abramov, AY; Canevari, L; Duchen, MR; (2004) beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J NEUROSCI , 24 (2) 565 - 575. 10.1523/JNEUROSCI.4042-03.2004.

Abramov, AY; Canevari, L; Duchen, MR; (2004) Amyloid beta peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. In: BIOPHYSICAL JOURNAL. (pp. 469A - 469A). BIOPHYSICAL SOCIETY

Ahluwalia, J; Tinker, A; Clapp, LH; Duchen, MR; Abramov, AY; Pope, S; ... Segal, AW; + view all (2004) The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retracted article. See vol. 468, 2010). NATURE , 427 (6977) 853 - 858. 10.1038/nature02356.

Ahluwalia, J.; Tinker, A.; Clapp, L.H.; Duchen, M.R.; Abramov, A.Y.; Pope, S.; ... Segal, A.W.; + view all (2004) The large-conductance Ca2+ -activated K+ channel is essential for innate immunity. Nature , 427 (6977) pp. 853-858. 10.1038/nature02356.

Canevari, L; Abramov, AY; Duchen, MR; (2004) Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress. NEUROCHEM RES , 29 (3) 637 - 650.

2003

Abramov, A.Y.; Canevari, L.; Duchen, M.R.; (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. Nature Chemical Biology , 23 (12) pp. 5088-5095. Green open access
file

Abramov, AY; Canevari, L; Duchen, MR; (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J NEUROSCI , 23 (12) 5088 - 5095.

Abramov, AY; Canevari, L; Duchen, MR; (2003) Amyloid beta peptide causes [Ca2+](c) fluctuations and decreases [GSH] in rat astrocytes. In: BIOPHYSICAL JOURNAL. (pp. 389A - 389A). BIOPHYSICAL SOCIETY

Abramov, AY; Duchen, MR; (2003) Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells. CELL CALCIUM , 33 (2) 101 - 112.

2001

Abramov, AY; Zamaraeva, MV; Hagelgans, AI; Azimov, RR; Krasilnikov, OV; (2001) Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers. BBA-BIOMEMBRANES , 1512 (1) 98 - 110.

Sukocheva, OA; Abramov, AY; Levitskaya, JO; Gagelgans, AI; Carpenter, DO; (2001) Modulation of intracellular Ca2+ concentration by vitamin B-12 in rat thymocytes. BLOOD CELL MOL DIS , 27 (5) 812 - 824. 10.1006/bcmd.2001.0450.

1999

Zamaraeva, MV; Hagelgans, AI; Lubnina, LV; Abramov, AY; Ahmedhodjaeva, HS; Saidhodjaev, AI; ... Salakhutdinov, BA; + view all (1999) Hormonal activity and membrane action of plants terpenoids. CELL MOL BIOL LETT , 4 (2) 189 - 201.

1998

Sagdullaev, BT; Abramov, AY; Gagelgans, AI; Dzhakhangirov, FN; Usmanov, PB; (1998) Effect of a diterpene alkaloid series on calcium homeostases of rat cardiomyocites - Structure-activity bond. KHIM PRIR SOEDIN+ (4) 523 - 526.

1997

Zamaraeva, MV; Hagelgans, AI; Abramov, AY; Ternovsky, VI; Merzlyak, PG; Tashmukhamedov, BA; Saidkhodzjaev, AI; (1997) Ionophoretic properties of ferutinin. CELL CALCIUM , 22 (4) 235 - 241.

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Abramov, AY; Human neuronal coenzyme Q(10) deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.

Abramov, AY; Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide.

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