UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
- Research Groups
- Cell Physiology
- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
- Contact us
Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
You are invited to an evening (13th March 2013) exploring the very latest in cutting edge research into neurodegenerative diseases. Supported by the Wellcome Trust, scientists investigating Alzheimer's, Parkinson's and Motor Neuron disease will explain how our understanding of these disorders is changing in the light of new discoveries in genetics and cell biology, and how these discoveries impact on developing new drugs for these diseases.
18.00 Welcome and introduction
18.10 Lectures commence
Drosophila Genetics Group
We are using the fruit fly, Drosophila melanogaster, as a genetic model to understand the causes of nervous system diseases, such as Parkinson’s disease. By studying the function of the fly counterparts of genes linked to Parkinson’s disease we will better understand the normal function of these genes and the consequences of when they fail.
Figure 1. Scanning electron micrograph of Drosophilia eye from (left) wild type and (right) fly co-expressing Parkin and PINK1 in the eye, demonstratting a synergistic genetic interaction disrupting the eye morphology.
We use Drosophila as a model system for Parkinson’s disease as it presents an excellent opportunity to bring in vivo genetic techniques to further our understanding of this disease. We have a wide array of tools available in Drosophila which provide very powerful approaches to unravel the basis of biological malfunctions associated with a disease.
Neurodegenerative diseases such as Parkinson’s disease present a major challenge to modern medicine. The identification of genes responsible for relatively rare heritable forms of this syndrome have provided valuable insight into the mechanisms of pathology.
Page last modified on 26 jan 11 14:14