UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
- Research Groups
- Cell Physiology
- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
- Contact us
A study published in Brain, led by researchers
at UCL Institute of Neurology, has shown that genetic mutations which
cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
In this paper Claudia Manzoni studies how fibroblast
cells from people with Parkinson’s disease caused by mutations in LRRK2
react to starvation. Although the changes are quite subtle, there are
differences between the way that fibroblasts that contain mutant LRRK2
respond to being starved – suggesting that there may be changes in the
way that these cells regulate a key process called autophagy (a term
which comes from the greek meaning to eat yourself, and is one of the
ways that cells get rid of waste and recycle proteins and organellles).
Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...
Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Here, Claudia Manzoni talks about her research (funded by the Rosetrees Trust and the Michael J. Fox Foundation) into what LRRK2 might be doing within the cell: Parkinson’s disease is a brain illness that afflicts 1 in 500 people in the UK. High profile patients, such as the actor Michael J Fox, the boxer Muhammad Ali and the late Pope John Paul II, have raised public awareness of Parkinson’s and its devastating impact. More...
Drosophila Genetics Group
We are using the fruit fly, Drosophila melanogaster, as a genetic model to understand the causes of nervous system diseases, such as Parkinson’s disease. By studying the function of the fly counterparts of genes linked to Parkinson’s disease we will better understand the normal function of these genes and the consequences of when they fail.
Figure 1. Scanning electron micrograph of Drosophilia eye from (left) wild type and (right) fly co-expressing Parkin and PINK1 in the eye, demonstratting a synergistic genetic interaction disrupting the eye morphology.
We use Drosophila as a model system for Parkinson’s disease as it presents an excellent opportunity to bring in vivo genetic techniques to further our understanding of this disease. We have a wide array of tools available in Drosophila which provide very powerful approaches to unravel the basis of biological malfunctions associated with a disease.
Neurodegenerative diseases such as Parkinson’s disease present a major challenge to modern medicine. The identification of genes responsible for relatively rare heritable forms of this syndrome have provided valuable insight into the mechanisms of pathology.
Page last modified on 26 jan 11 14:14