UK Parkinson's Disease Consortium - UKPDC
- Principal Investigators
- Research Groups
- Cell Physiology
- Clinical Neuroscience
- Clinical Studies
- Drosophila Genetics
- Molecular Biology and Biochemistry
- Molecular Neuropathology
- Neurological Biochemistry
- Neurological Signalling
- Protein Phosphorylation
- Contact us
Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Have you ever wondered how scientists research the brain? Have you wondered who digs through that beautiful mass of grey matter between our ears to understand how it works and why it stops working? Meet the Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this team of scientists from around the globe investigates Alzheimer's, Parkinson's and Motor Neuron Diseases. The team is on the hunt for understanding and treatments for brain diseases. More...
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
You are invited to an evening (13th March 2013) exploring the very latest in cutting edge research into neurodegenerative diseases. Supported by the Wellcome Trust, scientists investigating Alzheimer's, Parkinson's and Motor Neuron disease will explain how our understanding of these disorders is changing in the light of new discoveries in genetics and cell biology, and how these discoveries impact on developing new drugs for these diseases.
18.00 Welcome and introduction
18.10 Lectures commence
Clinical Studies Group
Parkinsonism is a descriptive term that includes Parkinson’s disease and other disorders that have similar symptoms. The commonest features of these conditions include abnormal stiffness, slowness of movement or shakiness. These outward changes are caused by the progressive loss of function and eventual death of certain key nerve cells within the brain.
One aim of our study is to understand as much as possible about what causes these nerve cells to die prematurely in people with parkinsonism. It is thought likely that both agents in the environment and genetic factors play a role in this process, but to varying degrees in individual cases. Several changes in the genes that influence the risk of developing parkinsonism have already been discovered during previous studies; it is likely, however, that there are many more which remain to be found. By looking at the genetic material (also called DNA) of people with parkinsonism and comparing it with that of people who do not have parkinsonism, we hope to identify new, unknown changes in the genes that increase the risk of developing this problem. From participants who carry such changes in their genes, we will seek to collect urine, blood and skin cells to study how they affect the normal workings of living cells in order to cause parkinsonism.
At present, we do not have a reliable way of identifying individuals who are at the very earliest stage in the disease. This would be important because if we develop medicines that slow down or maybe halt the progression of Parkinson’s disease, it is at this stage of the disease that they will be most beneficial. Another aim of this project is thus to study individuals, who we know are at higher risk of parkinsonism because they carry a change in their genes which is known to predispose to the condition, closely over a period of time in order to capture the very earliest stage of the condition.
The overall goal is to improve medical knowledge and understanding of Parkinson’s disease. It is hoped that scientific research into this disorder will ultimately help us to design a medicine that can slow down or stop the progress of the disease.
We would be interested to hear from any individuals with Parkinson’s disease who have a family history of the disorder as we are currently recruiting for research studies. Please contact Dr Una-Marie Sheerin here.
An increased prevalence of Parkinson's disease amongst sufferers and carriers of Gaucher disease has been confirmed by recent studies. The current project also aims to understand why Gaucher disease patients and
carriers have an increased chance of Parkinson's disease. To do this
we will assess a large group of people with Gaucher disease and carriers
for signs of early Parkinson's disease. If you would like to take part please contact Dr Alisdair McNeill here.
Page last modified on 31 jan 11 17:52