Leonard Wolfson Experimental Neurology Centre (LWENC)

The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials


Audioslide presentation on Claudia Manzoni's paper examining how fibroblasts with LRRK2 mutations react to starvation conditions and the possible deficits that they have in autophagy.

LRRK2 and autophagy in fibroblasts

In this paper Claudia Manzoni studies how fibroblast cells from people with Parkinson’s disease caused by mutations in LRRK2 react to starvation. Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved – suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles).

Drosophila fly model - University of Sheffield

Genetic mutations linked to Parkinson's disease

Research led by consortium researchers Dr Helene Plun-Favreau (UCL Institute of Neurology) and Dr Alex Whitworth (University of Sheffield), and collaborator Dr Heike Laman (University of Cambridge), has discovered how genetic mutations linked to Parkinson’s disease might play a key role in the death of brain cells, potentially paving the way for the development of more effective drug treatments. In the new study, published in Nature Neuroscience, the team of cross-institutional researchers showed how defects in the Parkinson’s gene Fbxo7 cause problems with mitophagy. More...


LRRK2 and autophagy

Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. Here, Claudia Manzoni talks about her research (funded by the Rosetrees Trust and the Michael J. Fox Foundation) into what LRRK2 might be doing within the cell: Parkinson’s disease is a brain illness that afflicts 1 in 500 people in the UK. High profile patients, such as the actor Michael J Fox, the boxer Muhammad Ali and the late Pope John Paul II, have raised public awareness of Parkinson’s and its devastating impact. More...

GBA neurons

GBA and mitochondria

Dr Laura Osellame tells us about her recent paper in Cell Metabolism about Mitochondrial dysfunction linked to loss of an enzyme called GBA: Gaucher Disease (GD) is a rare inherited disease, belonging to the family of lysosomal storage disorders. Mutations in the gene glucocerebrosidase (GBA) are responsible for the disease and can increase susceptibility to Parkinson’s disease (PD). Genetic studies undertaken at UCL and other hospitals around the world suggest that mutations in GBA are the most common genetic risk factor currently known for PD. More...

Video: Parkinson's and the Genetic Revolution: From Genes to Treatments

17 June 2013

Dr Patrick Lewis of University College London and Dr Flaviano Giorgini of the University of Leicester, discuss how their work on genetics is helping us develop treatments for Parkinson's.

The last ten years have seen a revolution in our understanding of genetics, demonstrated by the truly monumental sequencing of the human genome. This has, in turn, had a massive impact on the way in which we approach the research of human conditions -- including Parkinson's.

Poster: Parkinson's and the Genetic Revolution: From Genes to Treatments

We now know that there are many genes that are linked to Parkinson's, and much of the research into this condition over the past decade has attempted to bridge the gap between identifying these genes and figuring out why they cause nerve cells to die.

In this lecture, we will take you on a journey through the genetics of Parkinson's. We talk about how we as scientists are using genetics to learn about the causes of the condition -- providing us with new potential targets in the hunt for better treatments.

The Gretschen Amphlet Memorial Lecture 2013. Film footage of the lecture and Q&A taken at Fitzwilliam College Cambridge on the 17 April 2013.

Page last modified on 17 jun 13 10:15