UK Parkinson's Disease Consortium - UKPDC
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- Degenerating neurons
- Department of Molecular Neuroscience, UCL
- Department of Clinical Neuroscience, UCL
- MRC Protein Phosphorylation Unit, Dundee
- MRC Centre for Developmental and Biomedical Genetics, Sheffield
- Eisai Ltd
- Clinical Movement Disorders Group, UCL
- MRC Centre for Neuromuscular Diseases, UCL
- Neurodegeneration, UCL
- Neurophysiology of Human Development, UCL
- Pathophysiology of Human Movement Disorders, UCL
- Queen Square Brain Bank, UCL
- Reta Lila Weston Institute of Neurological Studies, UCL
- Sobell Department of Motor Neuroscience and Movement Disorders, UCL
- Unit of Functional Neurosurgery, UCL
- UCL Consortium for Mitochondrial Research
- UCL Genetics Institute (UGI)
- UCL Genomics
- Neurogenetics Unit, UCLH
- Neurometabolic Unit, UCLH
- Lysosomal Storage Disorders Unit, Royal Free
- School of Medicine and Dentistry, Aberdeen
- PD Med, Birmingham
- Cambridge Bristol Toronto Hamburg Neurodegenerative Disease Consortium
- Cambridge Centre for Brain Repair
- The Movement Disorders Group, Cambridge
- MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff
- MRC Centre for Regenerative Medicine, Edinburgh
- MRC Sudden Death Brain and Tissue Bank, Edinburgh
- The Institute of Cancer Research
- Bioinformatics, Statistical Genetics & Epigenetics, KCL
- MRC Toxicology Unit, Leicester
- Wellcome Trust Case Control Consortium
- WT/MRC Neurodegenarative Diseases Initiative
- Wellcome Trust Sanger Institute
- AMC Department of Neurology, Amsterdam
- Department of Clinical Genetics, VUMC
- Laboratory of Neurogenetics, NIA/NIH
- French National Institute of Health and Medical Research (Inserm)
- Brain & Spine Institute, Paris
- Centre-de-Physiopathologie-de-Toulouse-Purpan (CPTP)
- Department for Neurodegenerative Diseases, Tübingen
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News
Video: Parkinson's and the Genetic Revolution: From Genes to Treatments
Dr Patrick Lewis of
University College London and Dr Flaviano Giorgini of the University of
Leicester, discuss how their work on genetics is helping us develop treatments for Parkinson's.
More...
Public lecture: The autophagy signaling network, c-‐myc and pathology: don't mess with the cell cycle!
You are invited to a public lecture by Francesco Cecconi, an eminent scientist in the field of autophagy and neurodegeneration, on Thursday the 25th of April at 17:00, in the lecture theatre of 33 Queen Square, University College Hospital London, WC1N. The lecture will be followed by a general discussion with drinks and food. More...
Video: Brain Disease Research - Keeping You You
Have you ever wondered how scientists research the brain?
Have you wondered who digs through that beautiful mass of grey matter between
our ears to understand how it works and why it stops working? Meet the
Neurodegenerative Diseases Initiative. Funded by the Wellcome Trust and MRC, this
team of scientists from around the globe investigates Alzheimer's, Parkinson's
and Motor Neuron Diseases. The team is on the hunt for understanding and
treatments for brain diseases. More...
Video: Degenerating Brains public symposium
The "Degenerating Brains" public symposium was held on the 13th March 2013, as part of Brain Awareness Week. Around 250 people showed up to hear Professors John Hardy (UCL), Chris Shaw (KCL) and David Rubinsztein (Cambridge) discuss new discoveries in neurodegenerative diseases and how they might impact drug treatment. More...
Mutations in VCP gene implicated in a number of neurodegenerative diseases
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS). More...
Pathophysiology of Human Movement Disorders, UCL
Movement disorders cover a diverse range of neurological conditions from Parkinson’s disease to tremor and dystonia. They are thought of primarily as disorders of basal ganglia function, but the consequences of such dysfunction and the contribution of other brain areas are only beginning to be understood. Our current research has three broad aims: 1) To improve and develop clinical categorisation of movement disorders by researching electrophysiological “signatures” or biomarkers of particular disorders, 2) to use electrophysiological and psychophysical techniques to explore the pathophysiology of different movement disorders and 3) to research the possible application of rTMS in the treatment of movement disorders.
The Pathophysiology of Human Movement Disorders lab at the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology is based in number 33 Queen Square with access to state of the art electrophysiology facilities.
We use the following techniques:
- Transcranial magnetic stimulation to measure various parameters of cortical excitability.
- Repetitive transcranial magnetic stimulation, paired associative stimulation to explore brain plasticity.
- EEG
- Psychophysical assessments of reaction time, attention and learning.
Page last modified on 17 mar 11 11:12
