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chromosome 22q deletion

Parkinson's chromosome deletion linked to other genetic disorders

Researchers, led by BRC-supported Professor Nicholas Wood, UCL Institute of Neurology, have made a breakthrough in their understanding of Parkinson’s disease after they discovered a chromosome deletion linked to Parkinson’s disease and other genetic disorders. More...

Prof John Hardy

Prof John Hardy is the first UK winner of $3m Breakthrough Prize in Life Sciences

Professor John Hardy (UCL Institute of Neurology) has been awarded the $3 million Breakthrough Prize in Life Sciences for his pioneering research into the genetic causes of Alzheimer’s disease, other forms of dementia and Parkinson’s disease. More...

John Hardy, PhD, right, accepted the 2015 Robert A. Pritzker Prize from MJFF VP Brian Fiske, PhD, and Michael J. Fox on April 15.

John Hardy awarded 2015 Robert A. Pritzker Prize for Leadership in Parkinson's Research

One of the UK Parkinson's Disease Consortium Principal Investigators, Prof John Hardy, has been awarded the 2015 Robert A. Pritzker Prize for his leadership in Parkinson's genetics research. The award was presented by Michael J. Fox at a ceremony in New York on April 15. From the Michael J. Fox Foundation website: More...

Webcast - Prof Nicholas Wood - Advances in Genetic Understanding of Parkinson's Disease.

Video: Advances in Genetic Understanding of Parkinson's Disease

Webcast of the presentation entitled ‘Advances in Genetic Understanding of Parkinson's Disease’ given by Nicholas Wood (University College London, United Kingdom) presented at the Biochemical Society Hot Topic event, PINK1-Parkin Signalling in Parkinson’s Disease and Beyond, held in December 2014. More...

Pedigrees and I-FP-CIT SPECT scan images of the four families with GCH1 mutations involved in this study.

GCH1 gene and Parkinson's risk

A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine production in the brain and lead to a form of childhood-onset Dystonia, also play a role in the development of Parkinson’s disease.
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Michael Duchen

(Co-Investigator)

Michael Duchen


We are interested in a wide range of issues related to mitochondrial biology and cell signaling. Much of our current work is focused on interrelationships between calcium signaling, mitochondria and free radicals in cell physiology and pathophysiology. This work embraces questions about the contributions of mitochondrial function to intracellular calcium signaling; about the contributions of mitochondrial dysfunction to cell injury and cell death - by necrosis or apoptosis - in situations such as ischaemia, reperfusion injury.

As well as being a founding PI of the UK Parkinson's Disease Consortium, Prof Duchen is a founding PI of the MRC Centre for Neuromuscular Diseases and coordinator of the UCL Consortium for Mitochondrial research (UCL CfMR).

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Number of items: 297.

2015

Corona, JC; Duchen, MR; (2015) Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets? J Bioenerg Biomembr , 47 (1-2) 89 - 99. 10.1007/s10863-014-9576-6. Green open access
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Corona, JC; Duchen, MR; (2015) PPARγ and PGC-1α as therapeutic targets in Parkinson's. Neurochem Res , 40 (2) 308 - 316. 10.1007/s11064-014-1377-0.

2014

Blacker, TS; Mann, ZF; Gale, JE; Ziegler, M; Bain, AJ; Szabadkai, G; Duchen, MR; (2014) Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nat Commun , 5 , Article 3936. 10.1038/ncomms4936. Green open access
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Childs, AM; Pysden, K; Roper, H; Chow, G; Niks, EH; Kriek, M; Chinnery, PF; (2014) Clinical and pathological features associated with mutations in MICU1. In: NEUROMUSCULAR DISORDERS. (pp. 848 - 849).

Chouchani, E; Pell, V; Gaude, E; Aksentijevic, D; Shattock, M; Davidson, S; Duchen, M; (2014) P439Comparative metabolomics identifies conserved metabolic pathways that control mitochondrial ROS production during ischaemia reperfusion injury. Cardiovasc Res , 103 Suppl 1 S81 - ?. 10.1093/cvr/cvu091.118.

Chouchani, ET; Pell, VR; Gaude, E; Aksentijević, D; Sundier, SY; Robb, EL; Logan, A; (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. [Letter]. Nature , 515 (7527) 431 - 435. 10.1038/nature13909. Green open access
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Corona, JC; de Souza, SC; Duchen, MR; (2014) PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol , 253 16 - 27. 10.1016/j.expneurol.2013.12.012.

Duchen, MR; (2014) Pathways to calcium mediated neuronal injury: Starvation in the midst of plenty. ACTA PHYSIOLOGICA , 211 43 - 43.

Galvao, J; Davis, B; Tilley, M; Normando, E; Duchen, MR; Cordeiro, MF; (2014) Unexpected low-dose toxicity of the universal solvent DMSO. FASEB J , 28 (3) 1317 - 1330. 10.1096/fj.13-235440.

Ivanes, F; Faccenda, D; Gatliff, J; Ahmed, AA; Cocco, S; Cheng, CH; Allan, E; (2014) The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol , 171 (18) 4193 - 4206. 10.1111/bph.12638.

Kotiadis, VN; Duchen, MR; Osellame, LD; (2014) Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health. Biochim Biophys Acta , 1840 (4) pp. 1254-1265. 10.1016/j.bbagen.2013.10.041. Green open access
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Levine, AP; Duchen, MR; Segal, AW; (2014) The HVCN1 channel conducts protons across the phagocytic vacuole of neutrophils. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION , 44 16 - 16.

Logan, CV; Sharpe, JA; De Stefani, D; Raffaello, A; Rizzuto, R; Duchen, MR; Muntoni, F; (2014) Genetic defects in mitochondrial calcium handling cause neuromuscular disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION , 44 47 - 47.

Logan, CV; Szabadkai, G; Sharpe, JA; Parry, DA; Torelli, S; Childs, AM; Kriek, M; (2014) Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet , 46 (2) 188 - 193. 10.1038/ng.2851.

Osellame, LD; Duchen, MR; (2014) Quality Control Gone Wrong: Mitochondria, Lysosomal Storage Disorders and Neurodegeneration. Br J Pharmacol , 171 (8) pp. 1958-1972. 10.1111/bph.12453. Green open access
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Schwarzländer, M; Wagner, S; Ermakova, YG; Belousov, VV; Radi, R; Beckman, JS; Buettner, GR; (2014) The 'mitoflash' probe cpYFP does not respond to superoxide. Nature , 514 (7523) E12 - E14. 10.1038/nature13858.

2013

Alfieri, A; Srivastava, S; Siow, R; Modo, M; Duchen, M; Fraser, P; Mann, G; (2013) Sulforaphane pre-treatment reduces blood-brain barrier disruption in experimental stroke by inducing heme oxygenase-1 expression in the glio-vascular complex of the peri-infarct region. In: FASEB JOURNAL.

Alfieri, A; Srivastava, S; Siow, RC; Cash, D; Modo, M; Duchen, MR; Fraser, PA; (2013) Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke. Free Radic Biol Med , 65 1012 - 1022. 10.1016/j.freeradbiomed.2013.08.190.

Blacker, TS; Marsh, RJ; Duchen, MR; Bain, AJ; (2013) Activated barrier crossing dynamics in the non-radiative decay of NADH and NADPH. CHEMICAL PHYSICS , 422 184 - 194. 10.1016/j.chemphys.2013.02.019.

Chlystun, M; Campanella, M; Law, AL; Duchen, MR; Fatimathas, L; Levine, TP; Gerke, V; (2013) Regulation of mitochondrial morphogenesis by annexin a6. PLoS One , 8 (1) , Article e53774. 10.1371/journal.pone.0053774. Green open access
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Cleeter, MW; Chau, KY; Gluck, C; Mehta, A; Hughes, DA; Duchen, M; Wood, NW; (2013) Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage. Neurochem Int , 62 (1) 1 - 7. 10.1016/j.neuint.2012.10.010. Gold open access

Corona, JC; Duchen, MR; (2013) Rosiglitazone protects human neuron-like cells against complex I inhibition through improvement of mitochondrial function. In: JOURNAL OF NEUROCHEMISTRY. (pp. 177 - 178).

Faccenda, D; Tan, CH; Duchen, MR; Campanella, M; (2013) Mitochondrial IF1 preserves cristae structure to limit apoptotic cell death signaling. CELL CYCLE , 12 (16) 2530 - 2532. 10.4161/cc.25840.

Faccenda, D; Tan, CH; Duchen, MR; Campanella, M; (2013) Mitochondrial IF₁ preserves cristae structure to limit apoptotic cell death signaling. Cell Cycle , 12 (16) 2530 - 2532. 10.4161/cc.25840.

Faccenda, D; Tan, CH; Seraphim, A; Duchen, MR; Campanella, M; (2013) IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ , 20 (5) 686 - 697. 10.1038/cdd.2012.163.

Osellame, LD; Duchen, MR; (2013) Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases. Autophagy , 9 (10) pp. 1633-1635. 10.4161/auto.25878. Green open access
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Osellame, LD; Duchen, MR; (2013) Lysosomal dysfunction caused by glucocerebrosidase loss causes mitochondrial dysfunction as a consequence of impaired autophagy. In: JOURNAL OF NEUROSCIENCE RESEARCH. (pp. 1086 - 1086).

Osellame, LD; Rahim, AA; Hargreaves, IP; Gegg, ME; Richard-Londt, A; Brandner, S; Waddington, SN; (2013) Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease. Cell Metabolism , 17 (6) pp. 941-953. 10.1016/j.cmet.2013.04.014. Green open access
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Sadeghian, M; Haddad, AR; Mastrolia, V; Schiza, D; Sajic, M; Duchen, M; Smith, K; (2013) Loss of mitochondrial function and impaired mitochondrial trafficking at the onset of neurological deficits in a neuroinflammatory model of multiple sclerosis (MS) studied by in vivo confocal imaging. In: MULTIPLE SCLEROSIS JOURNAL. (pp. 46 - 47).

Sajic, M; Mastrolia, V; Lee, CY; Trigo, D; Sadeghian, M; Mosley, AJ; Gregson, NA; (2013) Impulse conduction increases mitochondrial transport in adult Mammalian peripheral nerves in vivo. PLoS Biol , 11 (12) , Article e1001754. 10.1371/journal.pbio.1001754. Green open access
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Zhou, H; Rokach, O; Feng, L; Munteanu, I; Mamchaoui, K; Wilmshurst, JM; Sewry, C; (2013) RyR1 deficiency in congenital myopathies disrupts excitation-contraction coupling. Hum Mutat , 34 (7) 986 - 996. 10.1002/humu.22326.

2012

Abeti, R; Duchen, MR; (2012) Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease. Neurochem Res , 37 (11) 2589 - 2596. 10.1007/s11064-012-0895-x.

Baruch, N; Duchen, M; Hanna, MG; (2012) Muscle degeneration in ion channel dysfunction. In: NEUROMUSCULAR DISORDERS. (pp. S16 - S16).

Blacker, TS; Mann, ZF; Gale, JE; Ziegler, M; Bain, AJ; Duchen, MR; (2012) Separation of NADPH and NADH Fluorescence Emission in Live Cells using Flim. In: BIOPHYSICAL JOURNAL. (pp. 196A - 196A).

Corona, JC; Duchen, MR; (2012) Rosiglitazone protects differentiated SH-SY5Y cells against damage induced by rotenone through mitochondrial biogenesis and by anti-oxidative mechanisms. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS , 1817 S68 - S68. 10.1016/j.bbabio.2012.06.192.

Davidson, SM; Duchen, MM; Yellon, DM; (2012) Slow calcium waves and redox changes precede mPTP opening occur during hypoxia and reoxygenation in the intact heart. In: CARDIOVASCULAR RESEARCH. (pp. S88 - S88).

Davidson, SM; Duchen, MR; (2012) Imaging mitochondrial calcium signalling with fluorescent probes and single or two photon confocal microscopy. Methods Mol Biol , 810 219 - 234. 10.1007/978-1-61779-382-0_14.

Davidson, SM; Yellon, DM; Murphy, MP; Duchen, MR; (2012) Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. Cardiovasc Res , 93 (3) 445 - 453. 10.1093/cvr/cvr349.

Ding, S; Riddoch-Contreras, J; Abramov, AY; Qi, Z; Duchen, MR; (2012) Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide. J Muscle Res Cell Motil , 33 (5) 339 - ?. 10.1007/s10974-012-9327-4.

Ding, S; Riddoch-Contreras, J; Abramov, AY; Qi, Z; Duchen, MR; (2012) Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide. J Muscle Res Cell Motil , 33 (5) 327 - 337. 10.1007/s10974-012-9318-5.

Duchen, MR; (2012) Mitochondria, calcium-dependent neuronal death and neurodegenerative disease. Pflugers Arch , 464 (1) 111 - 121. 10.1007/s00424-012-1112-0. Gold open access

Gandhi, S; Vaarmann, A; Yao, Z; Duchen, MR; Wood, NW; Abramov, AY; (2012) Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PLoS One , 7 (5) , Article e37564. 10.1371/journal.pone.0037564. Green open access
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Girard, M; Larivière, R; Parfitt, DA; Deane, EC; Gaudet, R; Nossova, N; Blondeau, F; (2012) Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Proc Natl Acad Sci U S A , 109 (5) 1661 - 1666. 10.1073/pnas.1113166109.

Munteanu, I; Zhou, H; Hargreaves, I; Yasukawa, T; Duchen, MR; Muntoni, F; (2012) Investigating mitochondria in cell culture models of core myopathies. In: NEUROMUSCULAR DISORDERS. (pp. S30 - S30).

Osellame, LD; Blacker, TS; Duchen, MR; (2012) Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab , 26 (6) 711 - 723. 10.1016/j.beem.2012.05.003. Gold open access

Osellame, LD; Rahim, A; Gegg, ME; Waddington, S; Schapira, AHV; Duchen, MR; (2012) Accumulation of damaged mitochondria in neuropathic Gaucher disease, the most prevalent risk factor for Parkinson's disease, is due to defective cellular degradation machinery. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S79 - S80).

Papkovskaia, TD; Chau, KY; Inesta-Vaquera, F; Papkovsky, DB; Healy, DG; Nishio, K; Staddon, J; (2012) G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. Hum Mol Genet , 21 (19) 4201 - 4213. 10.1093/hmg/dds244. Gold open access

Sadeghian, M; Mosely, A; Mastrolia, V; Mullali, G; Bowen, S; Sajic, M; Duchen, M; (2012) Mitochondrial fragmentation and loss of function at the onset of neurological deficit in a neuroinflammatory model of multiple sclerosis (MS) studied by in vivo imaging. In: JOURNAL OF NEUROIMMUNOLOGY. (pp. 124 - 125).

Schwarzländer, M; Murphy, MP; Duchen, MR; Logan, DC; Fricker, MD; Halestrap, AP; Müller, FL; (2012) Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol , 22 (10) 503 - 508. 10.1016/j.tcb.2012.07.007.

Traba, J; Del Arco, A; Duchen, MR; Szabadkai, G; Satrústegui, J; (2012) SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. Cell Death Differ , 19 (4) 650 - 660. 10.1038/cdd.2011.139.

Zhou, H; Feng, L; Munteanu, I; Duchen, M; Treves, S; Jungbluth, H; Muntoni, F; (2012) RyR1 deficiency in congenital myopathies disrupts excitation-contraction coupling and induces the second calcium release system via IP3R. In: NEUROMUSCULAR DISORDERS. (pp. S32 - S32).

2011

Abeti, R; Abramov, AY; Duchen, MR; (2011) beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. BRAIN , 134 1658 - 1672. 10.1093/brain/awr104.

Abramov, AY; Duchen, MR; (2011) Measurements of threshold of mitochondrial permeability transition pore opening in intact and permeabilized cells by flash photolysis of caged calcium. Methods Mol Biol , 793 299 - 309. 10.1007/978-1-61779-328-8_19.

Abramov, AY; Ionov, M; Pavlov, E; Duchen, MR; (2011) Membrane cholesterol content plays a key role in the neurotoxicity of beta-amyloid: implications for Alzheimer's disease. AGING CELL , 10 (4) 595 - 603. 10.1111/j.1474-9726.2011.00685.x.

Duchen, MR; Heath, K; Baruch, NB; Hanna, MG; Muntoni, F; (2011) Dysregulation of calcium and mitochondrial function as potential therapeutic targets in muscle disease. In: NEUROMUSCULAR DISORDERS. (pp. S1 - S2). PERGAMON-ELSEVIER SCIENCE LTD

Girard, M; Lariviere, R; Parfitt, D; Deane, E; Gaudet, R; Blondeau, F; Prenosil, G; (2011) Mitochondrial dysfunction and Purkinje cell loss in the human spastic ataxia ARSACS. In: MOLECULAR BIOLOGY OF THE CELL.

Hall, AM; Crawford, C; Unwin, RJ; Duchen, MR; Peppiatt-Wildman, CM; (2011) Multiphoton Imaging of the Functioning Kidney. J AM SOC NEPHROL , 22 (7) 1297 - 1304. 10.1681/ASN.2010101054.

2010

Abramov, AY; Duchen, MR; (2010) Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS , 1800 (3) 297 - 304. 10.1016/j.bbagen.2009.08.002.

Abramov, AY; Smulders-Srinivasan, TK; Kirby, DM; Acin-Perez, R; Enriquez, JA; Lightowlers, RN; Duchen, MR; (2010) Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations. BRAIN , 133 797 - 807. 10.1093/brain/awq015.

Ahluwalia, J; Tinker, A; Clapp, LH; Duchen, MR; Abramov, AY; Pope, S; Nobles, M; (2010) The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retraction of vol 427, pg 853, 2004). NATURE , 468 (7320) 122 - 122. 10.1038/nature09562.

Averaimo, S; Milton, RH; Duchen, MR; Mazzanti, M; (2010) Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress. FEBS LETT , 584 (10) 2076 - 2084. 10.1016/j.febslet.2010.02.073.

Duchen, MR; Szabadkai, G; (2010) Roles of mitochondria in human disease. ESSAYS BIOCHEM , 47 115 - 137. 10.1042/BSE0470115.

El-Kadi, AM; Bros-Facer, V; Deng, WH; Philpott, A; Stoddart, E; Banks, G; Jackson, GS; (2010) The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease. J BIOL CHEM , 285 (24) 18627 - 18639. 10.1074/jbc.M110.129320. Gold open access

Hall, AM; Campanella, M; Loesch, A; Duchen, MR; Unwin, RJ; (2010) Albumin Uptake in OK Cells Exposed to Rotenone: A Model for Studying the Effects of Mitochondrial Dysfunction on Endocytosis in the Proximal Tubule? NEPHRON PHYSIOL , 115 (2) P9 - P19. 10.1159/000314540.

Igosheva, N; Abramov, AY; Poston, L; Eckert, JJ; Fleming, TP; Duchen, MR; McConnell, J; (2010) Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes. PLOS ONE , 5 (4) , Article e10074. 10.1371/journal.pone.0010074. Green open access
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Munteanu, I; Yasukawa, T; Duchen, MR; Muntoni, F; (2010) Uncovering the role of mitochondria in the pathogenesis of core myopathies. In: NEUROMUSCULAR DISORDERS. (pp. S24 - S24). PERGAMON-ELSEVIER SCIENCE LTD

Ng, KE; Schwarzer, S; Duchen, MR; Tinker, A; (2010) The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1. J MEMBRANE BIOL , 234 (2) 137 - 147. 10.1007/s00232-010-9241-x.

Traba, J; Amigo, I; Rueda, C; Szabadkai, G; Duchen, MR; Satrustegui, J; del Arco, A; (2010) The Ca2+-dependent ATP-Mg/Pi carriers as novel regulators of the mitochondrial permeability transition pore. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. 130 - 130). ELSEVIER SCIENCE BV

2009

Campanella, M; Parker, N; Tan, CH; Hall, AM; Duchen, MR; (2009) IF1: setting the pace of the F1Fo-ATP synthase. TRENDS BIOCHEM SCI , 34 (7) 343 - 350. 10.1016/j.tibs.2009.03.006.

Campanella, M; Seraphim, A; Abeti, R; Casswell, E; Echave, P; Duchen, MR; (2009) IF1, the endogenous regulator of the F1Fo-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS , 1787 (5) 393 - 401. 10.1016/j.bbabio.2009.02.023.

Cantley, J; Selman, C; Shukla, D; Abramov, AY; Forstreuter, F; Esteban, MA; Claret, M; (2009) Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J CLIN INVEST , 119 (1) 125 - 135. 10.1172/JCI26934.

Dumollard, R; Carroll, J; Duchen, MR; Campbell, K; Swann, K; (2009) Mitochondrial function and redox state in mammalian embryos. SEMIN CELL DEV BIOL , 20 (3) 346 - 353. 10.1016/j.semcdb.2008.12.013.

Echave, P; Machado-da-Silva, G; Arkell, RS; Duchen, MR; Jacobson, J; Mitter, R; Lloyd, AC; (2009) Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis. J CELL SCI , 122 (24) 4516 - 4525. 10.1242/jcs.049734. Gold open access

Galkin, A; Abramov, AY; Frakich, N; Duchen, MR; Moncada, S; (2009) Lack of Oxygen Deactivates Mitochondrial Complex I IMPLICATIONS FOR ISCHEMIC INJURY? J BIOL CHEM , 284 (52) 36055 - 36061. 10.1074/jbc.M109.054346. Gold open access

Gandhi, S; Wood-Kaczmar, A; Wood, NW; Duchen, MR; Abramov, AY; (2009) PINK1 associated Parkinson's disease is caused by neuronal vulnerability to calcium induced cell death. In: MOVEMENT DISORDERS. (pp. S33 - S33). WILEY-LISS

Gandhi, S; Wood-Kaczmar, A; Yao, Z; Plun-Favreau, H; Deas, E; Klupsch, K; Downward, J; (2009) PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death. MOL CELL , 33 (5) 627 - 638. 10.1016/j.molcel.2009.02.013. Gold open access

Hall, AM; Unwin, RJ; Parker, N; Duchen, MR; (2009) Multiphoton Imaging Reveals Differences in Mitochondrial Function between Nephron Segments. J AM SOC NEPHROL , 20 (6) 1293 - 1302. 10.1681/ASN.2008070759. Gold open access

Mann, ZF; Duchen, MR; Gale, JE; (2009) Mitochondria modulate the spatio-temporal properties of intra- and intercellular Ca2+ signals in cochlear supporting cells. CELL CALCIUM , 46 (2) 136 - 146. 10.1016/j.ceca.2009.06.005.

Szabadkai, G; Duchen, MR; (2009) Mitochondria mediated cell death in diabetes. APOPTOSIS , 14 (12) 1405 - 1423. 10.1007/s10495-009-0363-5.

Wood-Kaczmar, A; Gandhi, S; Yao, Z; Abramov, AY; Miljan, EA; Keen, G; Stanyer, L; (2009) PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons. In: JOURNAL OF NEUROCHEMISTRY. (pp. 301 - 302). WILEY-BLACKWELL PUBLISHING, INC

Zolfaghari, P; Singer, M; Duchen, MR; (2009) UNCOUPLING PROTEIN-3 MEDIATES THE LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL IN SEVERE SEPSIS. In: INTENSIVE CARE MEDICINE. (pp. 164 - 164). SPRINGER

2008

Abramov, AY; Duchen, MR; (2008) Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS , 1777 (7-8) 953 - 964. 10.1016/j.bbabio.2008.04.017.

Bilsland, LG; Nirmalananthan, N; Yip, J; Greensmith, L; Duchen, MR; (2008) Expression of mutant SOD1(G93A) in astrocytes induces functional deficits in motoneuron mitochondria. J NEUROCHEM , 107 (5) 1271 - 1283. 10.1111/j.1471-4159.2008.05699.x.

Campanella, M; Casswell, E; Chong, S; Farah, Z; Wieckowski, MR; Abramov, AY; Tinker, A; (2008) Regulation of mitochondrial structure and function by the F1FO-ATPase inhibitor protein, IF1. CELL METAB , 8 (1) 13 - 25. 10.1016/j.cmet.2008.06.001.

Campanella, M; Tan, C; Abramov, A; Tinker, A; Duchen, M; (2008) Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S76 - S76). ELSEVIER SCIENCE BV

Davidson, SM; Duchen, M; Yellon, DM; (2008) Using multiphoton microscopy to examine the response of the heart to ischaemia and reperfusion injury. In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. (pp. 778 - 778). ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

Duchen, MR; Verkhratsky, A; Muallem, S; (2008) Mitochondria and calcium in health and disease. CELL CALCIUM , 44 (1) 1 - 5. 10.1016/j.ceca.2008.02.001.

Hall, AM; Unwin, RJ; Hanna, MG; Duchen, MR; (2008) Renal function and mitochondrial cytopathy (MC): more questions than answers. QJM-INT J MED , 101 (10) 755 - 766. 10.1093/qjmed/hcn060.

Milton, RH; Abeti, R; Averaimo, S; DeBiasi, S; Vitellaro, L; Jiang, L; Curmi, PMG; (2008) CLIC1 Function Is Required for beta-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia. J NEUROSCI , 28 (45) 11488 - 11499. 10.1523/JNEUROSCI.2431-08.2008.

Szabadkai, G; Duchen, MR; (2008) Mitochondria: The hub of cellular Ca2+ signaling (vol 23, pg 84, 2008). PHYSIOLOGY , 23 (4) 230 - 230. 10.1152/physiol.00101.2008.

Szabadkai, G; Duchen, MR; (2008) Mitochondria: The hub of cellular Ca2+ signaling. PHYSIOLOGY , 23 (2) 84 - 94. 10.1152/physiol.00046.2007.

Tan, CH; Campanella, M; Seraphim, A; Farah, Z; Conte, A; Duchen, MR; (2008) The inhibitory protein 1F(1) regulates cellular sensitivity to staurosporine-induced cell death. In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. S84 - S85). ELSEVIER SCIENCE BV

Wood-Kaczmar, A; Gandhi, S; Yao, Z; Abramov, ASY; Miljan, EA; Keen, G; Stanyer, L; (2008) PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons. PLOS ONE , 3 (6) , Article e2455. 10.1371/journal.pone.0002455. Green open access
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2007

Abramov, A; Fraley, C; Diao, C; Winkfein, R; Duchen, M; French, R; Pavlov, E; (2007) Polyphosphate in mitochondrial function. In: BIOPHYSICAL JOURNAL. (pp. 436A - 436A).

Abramov, AY; Fraley, C; Diao, CT; Winkfein, R; Colicos, MA; Duchen, MR; French, RJ; (2007) Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death. P NATL ACAD SCI USA , 104 (46) 18091 - 18096. 10.1073/pnas.0708959104. Gold open access

Abramov, AY; Scorziello, A; Duchen, MR; (2007) Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J NEUROSCI , 27 (5) 1129 - 1138. 10.1523/JNEUROSCI.4468-06.2007.

Campanella, M; Tinker, A; Duchen, MR; (2007) Studies of the endogenous inhibitor of the mitochondrial ATPase, IFt, in intact cells. In: BIOPHYSICAL JOURNAL. (pp. 640A - 640A). BIOPHYSICAL SOCIETY

Davidson, SM; Duchen, MR; (2007) Endothelial mitochondria - Contributing to vascular function and disease. CIRC RES , 100 (8) 1128 - 1141. 10.1161/01.RES.0000261970.18328.1d.

Davidson, SM; Yellon, D; Duchen, MR; (2007) Assessing mitochondrial potential, calcium, and redox state in isolated mammalian cells using confocal microscopy. Methods Mol Biol , 372 421 - 430. 10.1007/978-1-59745-365-3_30.

Dumollard, R; Duchen, M; Carroll, J; (2007) The role of mitochondrial function in the oocyte and embryo. CURR TOP DEV BIOL , 77 21 - +. 10.1016/S0070-2153(06)77002-8.

Dumollard, R; Ward, Z; Carroll, J; Duchen, MR; (2007) Regulation of redox metabolism in the mouse oocyte and embryo. DEVELOPMENT , 134 (3) 455 - 465. 10.1242/dev.02744.

Dumollard, R; Ward, Z; Carroll, J; Duchen, MR; (2007) Regulation of redox metabolism in the mouse oocyte and embryo. Development , 134 (3) 455 - 465.

McKenzie, M; Liolitsa, D; Akinshina, N; Campanella, M; Sisodiya, S; Hargreaves, I; Nirmalananthan, N; (2007) Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. J BIOL CHEM , 282 (51) 36845 - 36852. 10.1074/jbc.M704158200. Gold open access

Ogston, N; Hosseinzadeh-Attar, M; Duchen, M; Horakova, O; Kopecky, J; Johnston, S; Speakman, J; (2007) Prostacyclin synthase activity regulates the adipose depot specific IL-6 secretion. In: INTERNATIONAL JOURNAL OF OBESITY. (pp. S69 - S69). NATURE PUBLISHING GROUP

Ogston, NC; Sharpe, MA; Flachs, P; Ricquier, D; Kopecky, J; Duchen, MR; Mohamed-Ali, V; (2007) Uncoupling protein-2 expression and activity in white adipocytes: modulation of mitochondrial membrane potential and cellular redox state in response to lipid load and reactive oxygen species. DIABETIC MED , 24 41 - 41.

2006

Brennan, JP; Berry, RG; Baghai, M; Duchen, MR; Shattock, MJ; (2006) FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation. CARDIOVASC RES , 72 (2) 322 - 330. 10.1016/j.cardiores.2006.08.006.

Brennan, JP; Southworth, R; Medina, RA; Davidson, SM; Duchen, MR; Shattock, MJ; (2006) Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of K-ATP channel activation. CARDIOVASC RES , 72 (2) 313 - 321. 10.1016/j.cardiores.2006.07.019.

Davidson, SM; Duchen, MR; (2006) Calcium microdomains and oxidative stress. CELL CALCIUM , 40 (5-6) 561 - 574. 10.1016/j.ceca.2006.08.017.

Davidson, SM; Duchen, MR; (2006) Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance. CARDIOVASC RES , 71 (1) 10 - 21. 10.1016/j.cardiores.2006.01.019.

Davidson, SM; Hausenloy, D; Duchen, MR; Yellon, DM; (2006) Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. INT J BIOCHEM CELL B , 38 (3) 414 - 419. 10.1016/j.biocel.2005.09.017.

Dumollard, R; Duchen, M; Sardet, C; (2006) Calcium signals and mitochondria at fertilisation. Semin Cell Dev Biol , 17 (2) 314 - 323. 10.1016/j.semcdb.2006.02.009.

Jia, HY; Bagherzadeh, A; Bicknell, R; Duchen, MR; Liu, D; Zachary, I; (2006) Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells (vol 279, pg 36148, 2004). J BIOL CHEM , 281 (8) 5328 - 5328. Gold open access

Smart, N; Mojet, MH; Latchman, DS; Marber, MS; Duchen, MR; Heads, RJ; (2006) IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. CARDIOVASC RES , 69 (1) 164 - 177. 10.1016/j.cardiores.2005.08.017.

2005

Abramov, AY; Canevari, L; Duchen, MR; (2005) Expression, function and modulation of an NADPH oxidase in mammalian astrocytes. In: BIOPHYSICAL JOURNAL. (pp. 256A - 257A). BIOPHYSICAL SOCIETY

Abramov, AY; Duchen, MR; (2005) The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES , 360 (1464) 2309 - 2314. 10.1098/rstb.2005.1766. Gold open access

Abramov, AY; Duchen, MR; (2005) Mechanisms underlying the loss of mitochondrial potential calcium homeostasis in neurons during glutamate excitotoxicity. In: JOURNAL OF NEUROCHEMISTRY. (pp. 246 - 246).

Abramov, AY; Jacobson, J; Wientjes, F; Hothersall, J; Canevari, L; Duchen, MR; (2005) Expression and modulation of an NADPH oxidase in mammalian astrocytes. J NEUROSCI , 25 (40) 9176 - 9184. 10.1523/JNEUROSCI.1632-05.2005.

Abrarnov, AY; Wientjes, F; Canevari, L; Duchen, MR; (2005) An NADPH oxidase in astrocytes: Expression, function and pathophysiological role in the neurotoxicity of beta amyloid. In: JOURNAL OF NEUROCHEMISTRY. (pp. 66 - 66). BLACKWELL PUBLISHING

Jacobson, J; Duchen, MR; Hothersall, J; Clark, JB; Heales, SJR; (2005) Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism. J NEUROCHEM , 95 (2) 388 - 395. 10.1111/j.1471-4159.2005.03374.x.

Kouri, K; Duchen, MR; Lemmens-Gruber, R; (2005) Effects of beauvericin on the metabolic state and ionic homeostasis of ventricular myocytes of the guinea pig. CHEM RES TOXICOL , 18 (11) 1661 - 1668. 10.1021/tx050096g.

Liolitsa, D; McKenzie, M; Hargreaves, I; Heales, S; Land, J; Sisodiya, SM; Wood, NW; (2005) MELAS, a young-onset stroke disorder associated with a homoplasmic ND5 mitochondrial DNA mutation. EUR J NEUROL , 12 158 - 159.

Pitter, JG; Szanda, G; Duchen, MR; Spat, A; (2005) Prostaglandin F-2 alpha potentiates the calcium dependent activation of mitochondrial metabolism in luteal cells. CELL CALCIUM , 37 (1) 35 - 44. 10.1016/j.ceca.2004.06.004.

Shanmuganathan, S; Hausenloy, DJ; Duchen, MR; Yellon, DM; (2005) Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. AM J PHYSIOL-HEART C , 289 (1) H237 - H242. 10.1152/ajpheart.01192.2004.

2004

Abramov, A.Y.; Canevari, L.; Duchen, M.R.; (2004) β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. Journal of Neuroscience , 24 (2) pp. 565-575. 10.1523/JNEUROSCI.4042-03.2004. Green open access
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Abramov, AY; Canevari, L; Duchen, MR; (2004) Calcium signals induced by amylold beta peptide and their consequences in neurons and astrocytes in culture. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH , 1742 (1-3) 81 - 87. 10.1016/j.bbamcr.2004.09.006.

Abramov, AY; Canevari, L; Duchen, MR; (2004) beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J NEUROSCI , 24 (2) 565 - 575. 10.1523/JNEUROSCI.4042-03.2004.

Abramov, AY; Canevari, L; Duchen, MR; (2004) Amyloid beta peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. In: BIOPHYSICAL JOURNAL. (pp. 469A - 469A). BIOPHYSICAL SOCIETY

Ahluwalia, J; Tinker, A; Clapp, LH; Duchen, MR; Abramov, AY; Pope, S; Nobles, M; (2004) The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retracted article. See vol. 468, 2010). NATURE , 427 (6977) 853 - 858. 10.1038/nature02356.

Ahluwalia, J.; Tinker, A.; Clapp, L.H.; Duchen, M.R.; Abramov, A.Y.; Pope, S.; Nobles, M.; (2004) The large-conductance Ca2+ -activated K+ channel is essential for innate immunity. Nature , 427 (6977) pp. 853-858. 10.1038/nature02356.

Canevari, L; Abramov, AY; Duchen, MR; (2004) Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress. NEUROCHEM RES , 29 (3) 637 - 650.

Davidson, SM; Hausenloy, D; Duchen, MR; Yellon, DM; (2004) Insulin inhibits opening of the mitochondrial permeability transition pore via the reperfusion injury salvage kinase (RISK) pathway. In: CIRCULATION. (pp. 29 - 29). LIPPINCOTT WILLIAMS & WILKINS

Duchen, MR; (2004) Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol Aspects Med , 25 (4) 365 - 451. 10.1016/j.mam.2004.03.001.

Duchen, MR; (2004) Roles of mitochondria in health and disease. DIABETES , 53 S96 - S102.

Dumollard, R; Marangos, P; Fitzharris, G; Swann, K; Duchen, M; Carroll, J; (2004) Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production. DEVELOPMENT , 131 (13) 3057 - 3067. 10.1242/dev.01181.

Hausenloy, D; Wynne, A; Duchen, M; Yellon, D; (2004) Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. CIRCULATION , 109 (14) 1714 - 1717. 10.1161/01.CIR.0000126294.81407.7D. Green open access
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Hausenloy, D; Wynne, A; Yellon, DM; Duchen, M; (2004) Does the mitochondrial permeability transition have a role in preconditioning? Response. CIRCULATION , 110 (11) E303 - E303.

Hausenloy, DJ; Wynne, A; Duchen, M; Yellon, DM; (2004) Does the mitochondrial permeability transition pore have a role in preconditioning?-letter to editor. UNSPECIFIED

Hausenloy, DJ; Yellon, DM; Mani-Babu, S; Duchen, MR; (2004) Preconditioning protects by inhibiting the mitochondrial permeability transition. AM J PHYSIOL-HEART C , 287 (2) H841 - H849. 10.1152/ajpheart.00678.2003.

Jacobson, J; Duchen, MR; (2004) Interplay between mitochondria and cellular calcium signalling. MOL CELL BIOCHEM , 256 (1-2) 209 - 218.

Jia, HY; Bagherzadeh, A; Bicknell, R; Duchen, MR; Liu, D; Zachary, I; (2004) Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. J BIOL CHEM , 279 (34) 36148 - 36157. 10.1074/jbc.M401538200. Gold open access

McKenzie, M; Liolitsa, D; Sisodiya, S; Wood, N; Duchen, M; Hanna, M; (2004) A homoplasmic ND5 mutation associated with MELAS: mitochondria as ATP consumers? In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. (pp. 41 - 41). ELSEVIER SCIENCE BV

Rizzuto, R; Duchen, MR; Pozzan, T; (2004) Flirting in little space: the ER/mitochondria Ca2+ liaison. Sci STKE , 2004 (215) re1 - ?. 10.1126/stke.2152004re1.

Rizzuto, R; Duchen, MR; Pozzan, T; (2004) Flirting in little space: the ER/mitochondria Ca2+ liaison. Sci STKE , 215 re1, 13 - ?.

Shanmuganathan, S; Hausenloy, DJ; Duchen, MR; Yellon, DM; (2004) Inhibiting mitochondrial permeability transition pore opening protects the human myocardium from ischemia-reperfusion injury. In: CIRCULATION. (pp. 235 - 235). LIPPINCOTT WILLIAMS & WILKINS

Surin, AM; Storozhevykh, TP; Vinskaya, NP; Pinelis, VG; Duchen, MR; Khodorov, BI; (2004) Does mitochondrial ATp synthase reversal play a crucial role in glutamate-induced deterioration of Ca2+ homeostasis in mature hippocampal cultured neurons? BIOL MEMBRANY , 21 (2) 157 - 159.

2003

Abramov, A.Y.; Canevari, L.; Duchen, M.R.; (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. Nature Chemical Biology , 23 (12) pp. 5088-5095. Green open access
file

Abramov, AY; Canevari, L; Duchen, MR; (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J NEUROSCI , 23 (12) 5088 - 5095.

Abramov, AY; Canevari, L; Duchen, MR; (2003) Amyloid beta peptide causes [Ca2+](c) fluctuations and decreases [GSH] in rat astrocytes. In: BIOPHYSICAL JOURNAL. (pp. 389A - 389A). BIOPHYSICAL SOCIETY

Abramov, AY; Duchen, MR; (2003) Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells. CELL CALCIUM , 33 (2) 101 - 112.

Duchen, MR; (2003) Mitochondria and calcium signalling; point counter point. In: Berridge, M, (ed.) Handbook of Cell Signalling. (73 - 77). Elsevier: USA.

Duchen, MR; Surin, A; Jacobson, J; (2003) Imaging mitochondrial function in intact cells. METHOD ENZYMOL , 361 353 - 389.

Hausenloy, D.J.; Duchen, M.R.; Yellon, D.M.; (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia–reperfusion injury. Cardiovascular Research , 60 (3) pp. 617-625. 10.1016/j.cardiores.2003.09.025.

Hausenloy, DJ; Duchen, MR; Yellon, DM; (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. CARDIOVASC RES , 60 (3) 617 - 625. 10.1016/j.cardiores.2003.09.025.

Hausenloy, DJ; Wynne, AM; Duchen, MR; Yellon, DM; (2003) Transient mitochondrial permeability transition pore opening mediates ischemic preconditioning-induced protection. In: CIRCULATION. (pp. 220 - 220). LIPPINCOTT WILLIAMS & WILKINS

Monastyrkaya, EA; Andreeva, LV; Duchen, MR; Manuknina, EB; Malyshev, IY; (2003) Direct and cross-protective effects of heat adaptation in cultured cells. B EXP BIOL MED+ , 135 (2) 127 - 129.

Monastyrskaya, EA; Andreeva, LV; Duchen, MR; Wiegant, F; Bayda, LA; Manukhina, EB; Malyshev, IY; (2003) Adaptation to heat of cardiomyoblasts in culture protects them against heat shock: Role of nitric oxide and heat shock proteins. BIOCHEMISTRY-MOSCOW+ , 68 (7) 816 - 821.

Monastyrskaya, EA; Duchen, MR; Andreeva, LV; Viegant, F; Manukhina, EB; Malyshev, IY; (2003) Antiapoptotic effect of heat adaptation in cultured cells. B EXP BIOL MED+ , 135 (2) 123 - 126.

2002

Brennan, JP; Duchen, MR; Shattock, MJ; (2002) The anti-ischemic effect of low-dose FCCP involves mitochondrial oxidation without detectable depolarisation. J MOL CELL CARDIOL , 34 (6) A13 - A13.

Casley, CS; Land, JM; Sharpe, MA; Clark, JB; Duchen, MR; Canevari, L; (2002) beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. NEUROBIOL DIS , 10 (3) 258 - 267.

Duchen, MR; (2002) Roles of mitochondria, calcium and NO in glutamate excitotoxicity. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. 10S - 10S). CAMBRIDGE UNIV PRESS

Duchen, MR; Surin, AM; (2002) On the roles of mitochondria and calcium in glutamate induced neurotoxicity in hippocampal neurons in culture. BIOL MEMBRANY , 19 (1) 4 - 16.

Hausenloy, DJ; Mani-Babu, S; Duchen, MR; Yellon, DM; (2002) Mitochondrial KATP channel activation protects the myocyte against oxidative stress by inhibiting mitochondrial permeability transition pore opening. In: CIRCULATION. (pp. 230 - 230). LIPPINCOTT WILLIAMS & WILKINS

Jacobson, J; Duchen, MR; (2002) Mitochondrial oxidative stress and cell death in astrocytes - requirement for stored Ca2+ and sustained opening of the permeability transition pore. J CELL SCI , 115 (6) 1175 - 1188.

Jacobson, J; Duchen, MR; Heales, SJR; (2002) Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass. J NEUROCHEM , 82 (2) 224 - 233.

Krieger, C; Duchen, MR; (2002) Mitochondria, Ca2+ and neurodegenerative disease. EUR J PHARMACOL , 447 (2-3) 177 - 188.

Mohamed-Ali, V; Goodrick, SJ; Erusalimsky, JD; Mathur, A; Sharpe, M; Duchen, MR; (2002) Redox state, mitochondrial membrane potential and UCP expression in relation to lipid content in adipocytes. BIOPHYS J , 82 (1) 344A - 344A.

Robb, SJ; Brealey, D; Karyampudi, S; Duchen, MR; Bellingan, G; Singer, M; (2002) Decrease in VO2 in renal tubules from septic rats relates to clinical severity and nitric oxide. In: INTENSIVE CARE MEDICINE. (pp. S64 - S64). SPRINGER-VERLAG

Robb, SJ; Goss, A; Duchen, MR; Singer, M; (2002) Nitric oxide independent inhibition of the mitochondrial respiratory chain in HepG2 cells. In: INTENSIVE CARE MEDICINE. (pp. S63 - S63). SPRINGER-VERLAG

Song, GJ; Harding, SE; Duchen, MR; Tunwell, R; O'Gara, P; Hawkins, TE; Moss, SE; (2002) Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice. FASEB J , 16 (2) 622 - +. 10.1096/fj.01-0892fje.

2001

Duchen, M; Abramov, A; (2001) Actions of Ca(2+) ionophores on mitochondria in intact cells. BIOPHYSICAL JOURNAL , 80 (1) 614A - 615A.

Duchen, M; Mojet, M; Jacobson, DJ; Keelan, J; Vergun, O; (2001) Imaging mitochondrial function in single cells. In: Periasamy, A, (ed.) Methods in Cellular Imaging. (88 - 111). American Physiological Society, Oxford University Press

Jacobson, J; Duchen, MR; (2001) What nourishes me, destroys me': towards a new mitochondrial biology. CELL DEATH DIFFER , 8 (10) 963 - 966.

Jacobson, J; Duchen, MR; Clark, JB; Heales, SJR; (2001) Assay of mitochondrial cardiolipin content in cortical astrocytes. J NEUROCHEM , 78 25 - 25.

Keelan, J; Allen, NJ; Antcliffe, D; Pal, S; Duchen, MR; (2001) Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane. J NEUROSCI RES , 66 (5) 873 - 884.

Rakhit, RD; Mojet, MH; Marber, MS; Duchen, MR; (2001) Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. CIRCULATION , 103 (21) 2617 - 2623.

Vergun, O; Sobolevsky, AI; Yelshansky, MV; Keelan, J; Khodorov, BI; Duchen, MR; (2001) Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. J PHYSIOL-LONDON , 531 (1) 147 - 163.

2000

Beltran, B; Mathur, A; Duchen, MR; Erusalimsky, JD; Moncada, S; (2000) The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. P NATL ACAD SCI USA , 97 (26) 14602 - 14607.

Duchen, MR; (2000) Mitochondria and calcium: from cell signalling to cell death. JOURNAL OF PHYSIOLOGY-LONDON , 529 (1) 57 - 68.

Duchen, MR; (2000) Symposium overview. J PHYSIOL-LONDON , 529 (1) 2 - 2.

Duchen, MR; (2000) Mitochondria and Ca2+ in cell physiology and pathophysiology. CELL CALCIUM , 28 (5-6) 339 - 348. 10.1054/ceca.2000.0170.

Duchen, MR; (2000) Mitochondria and Ca<sup>2+</sup> in cell physiology and pathophysiology<b> </b>. Cell Calcium , 28 (5) 339 - 348.

Keelan, J; Allen, NJ; Antcliffe, D; Pal, S; Heales, S; Duchen, MR; (2000) Quantitative confocal microscopic measurement of glutathione levels in mixed hippocampal cultures. J PHYSIOL-LONDON , 525 68P - 69P.

Mojet, M; Jacobson, DJ; Keelan, J; Vergun, O; Duchen, MR; (2000) Monitoring mitochondrial function in single cells. In: Tepikin, A, (ed.) Calcium Signalling. (79 - 110). IRL Press,OUP: Oxford.

1999

Ashmore, JF; Bolsover, SR; Cockcroft, S; Duchen, MR; Koffer, A; Moss, SE; Swann, K; (1999) Imaging as applied to cell signalling: work from the Physiology Imaging Consortium (UCL.PIC). In: Journal of Physiology. (pp. 25 - ?).

Boitier, E; Rea, R; Duchen, MR; (1999) Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes. J CELL BIOL , 145 (4) 795 - 808.

Boitier, E; Rea, R; Duchen, MR; (1999) Modulation of the propagation of intracellular calcium waves by mitochondria in rat cortical astrocytes. In: BIOPHYS J. (pp. A223 - A223). BIOPHYSICAL SOCIETY

Boitier, E; Rea, R; Duchen, MR; (1999) Mitochondria exert a negative feedback control on the propagation of intracellular [Ca<sup>2+</sup>]<sub>i</sub> waves in adult rat cortical astrocytes. The Journal of Cell Biology , 145 795 - 808.

Duchen, MR; (1999) Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J PHYSIOL-LONDON , 516 (1) 1 - 17.

Duchen, MR; (1999) Mitochondrial contributions to animal physiology: from homeostatic sensor to calcium signalling and cell death. The Journal of Physiology , 516 1 - 17.

Duchen, MR; Boitier, E; Jacobson, D; Keelan, J; Vergun, O; (1999) Imaging mitochondrial function and cytosolic calcium in single mammalian cells. In: Journal of Physiology. (pp. 6 - ?).

Ibarreta, D; Duchén, M; Ma, D; Qiao, L; Kozikowski, AP; Etcheberrigaray, R; (1999) Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells. Neuroreport , 10 (5) 1035 - 1040.

Keelan, J; Vergun, O; Duchen, MR; (1999) Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons. J PHYSIOL-LONDON , 520 (3) 797 - 813.

Keelan, J; Vergun, O; Duchen, MR; (1999) Dynamics of intracellular calcium and mitochondrial potential during excitotoxicity in hippocampal neurons. In: Society for Neuroscience Abstracts. (pp. 1603 - 1603).

Keelan, J; Vergun, O; Duchen, MR; (1999) The synergistic action of calcium and nitric oxide causes mitochondrial depolarisation during toxic glutamate exposure in hippocampal neurones. The Journal of Physiology , 520 (3) 797 - 813.

Mojet, MH; Duchen, MR; (1999) Imaging transmission spectroscopy in the isolated carotid body (with simultaneous recordings of carotid sinus nerve activity). In: Journal of Physiology. (pp. 5 - ?).

Rakhit, RD; Mojet, MH; Duchen, MR; (1999) Mitochondrial depolarisation by nitric oxide protects cardiomyocytes against calcium overload injury during simulated ischemia-reperfusion (I/R). In: CIRCULATION. (pp. 243 - 243). LIPPINCOTT WILLIAMS & WILKINS

Rakhit, RD; Mojet, MH; Edwards, RJ; Aldous, A; Duchen, MR; Marber, MS; (1999) Nitric oxide modulates mitochondrial function in neonatal cardiocytes by reversible inhibition of respiration. In: European Heart Journal. (pp. 123 - 123).

Song, GJ; Harding, SE; Duchen, M; O'Gara, P; Hawkins, T; Moss, SE; (1999) Altered cardiomyocyte dynamics in annexin VI knockout mice. CIRCULATION , 100 (18) 762 - 763.

Vergun, O; Keelan, J; Duchen, MR; (1999) Contribution of reactive oxygen species (ROS) to the mitochondrial depolarization and perturbation of calcium homeostasis associated with glutamate toxicity. In: Society for Neuroscience Abstracts. (pp. 1866 - 1866).

Vergun, O; Keelan, J; Khodorov, BI; Duchen, MR; (1999) Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones. J PHYSIOL-LONDON , 519 (2) 451 - 466.

1998

Duchen, MR; Leyssens, A; Crompton, M; (1998) Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes. J CELL BIOL , 142 (4) 975 - 988.

Duchen, MR; Leyssens, A; Crompton, M; (1998) Transient mitochondrial depolarisations in response to focal SR calcium release in single rat cardiomyocytes. The Journal of Cell Biology , 142 975 - 988.

Jacobson, D; Duchen, MR; (1998) Fluorescence imaging of the mitochondrial permeability transition in rat cortical astrocytes in culture. In: J PHYSIOL-LONDON. (pp. 75P - 76P). CAMBRIDGE UNIV PRESS

Jacobson, D; Duchen, MR; (1998) Fluorescence imaging of the mitochondrial permeability transition in rat cortical astrocytes in culture. In: Journal of Physiology. (pp. 75 - ?).

Keelan, J; Hersson-Ringskog, J; Sioftanos, G; Sritharan, K; Vergun, O; Duchen, MR; (1998) Nitric oxide contributes to glutamate-induced mitochondrial dysfunction in rat hippocampal neurones in culture. J PHYSIOL-LONDON , 511P 122P - 123P.

Keelan, J; Vergun, O; Duchen, MR; (1998) Is there a role for the mitochondrial permeability transition in the initial stages of glutamate excitotoxicity? In: Society for Neuroscience Abstracts. (pp. 1453 - ?).

Keelan, J; Vergun, O; Hersson-Ringskog, J; Sritharan, K; Sioftanos, G; Duchen, MR; (1998) Nitric oxide contributes to glutamate-induced mitochondrial dysfunction in rat hippocampal neurons in culture. In: Journal of Physiology. (pp. 122 - ?).

Keelan, J; Vergun, O; Khodorov, B; Duchen, MR; (1998) Calcium-dependent mitochondrial depolarisation specific to toxic glutamate stimulation in cultured rat hippocampal neurones. In: Journal of Physiology. (pp. 75 - ?).

Keelan, J; Vergun, O; Khodorov, BI; Duchen, MR; (1998) Calcium-dependent mitochondrial depolarization specific to toxic glutamate stimulation in cultured rat hippocampal neurones. In: J PHYSIOL-LONDON. (pp. 75P - 75P). CAMBRIDGE UNIV PRESS

Morris, SH; Keelan, J; Patterson, DL; Duchen, MR; Bindman, LJ; (1998) Group I metabotropic glutamate receptor (mGluR) agonists raise intracellular [Ca<sup><i>2+</sup></i>] in medial frontal cortical neurones of the rat. In: Society for Neuroscience Abstracts. (pp. 2024 - ?).

Nowicky, AV; Duchen, MR; (1998) Changes in [Ca2+](i) and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons. J PHYSIOL-LONDON , 507 (1) 131 - 145.

Nowicky, AV; Duchen, MR; (1998) Changes in [Ca<sup>2+</sup>]i and membrane currents in response to impaired mitochondrial metabolism in dissociated rat hippocampal neurons. The Journal of Physiology , 507 131 - 146.

Vergun, O; Khodorov, B; Duchen, MR; (1998) Does mitochondrial function underlie the glutamate induced deterioration of neuronal calcium homeostasis? In: Society for Neuroscience Abstracts. (pp. 1452 - ?).

1997

Duchen, MR; Boitier, E; Jacobson, J; Leyssens, A; Peuchen, S; (1997) Mitochondria, free radicals & intracellular calcium in cell injury studied in single mammalian cells. In: BIOPHYS J. (pp. WP260 - WP260). BIOPHYSICAL SOCIETY

Keelan, J; Vergun, O; Patterson, DL; Duchen, MR; (1997) Excitotoxicity, cellular calcium signalling and mitochondrial (dys)function in cultured hippocampal neurons. In: Society for Neuroscience Abstracts.

Mojet, MH; Mills, E; Duchen, MR; (1997) Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration. J PHYSIOL-LONDON , 504 (1) 175 - 189.

Peuchen, S; Bolanos, JP; Heales, S; Duchen, MR; Clark, JB; (1997) Interrelationships between astrocyte function, oxidative stress and antioxidant status in the CNS. Progress in Neurobiology , 52 261 - 281.

Peuchen, S; Bolanos, JP; Heales, SJR; Almeida, A; Duchen, MR; Clark, JB; (1997) Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. PROG NEUROBIOL , 52 (4) 261 - 281.

Peuchen, S; Duchen, MR; Clark, JB; (1997) Modulation of gluthathione redox state in adult astrocytes. In:

1996

Duchen, MR; (1996) Raised intramitochondrial calcium stimulates ATP depletion by the mitochondrial F1F0-ATPase during metabolic inhibition in single mouse sensory neurons in culture. J PHYSIOL-LONDON , 491P P134 - P134.

Duchen, MR; Leyssens, A; Mojet, MH; Peuchen, S; (1996) Properties of rhod-2 as an indicator of intra-mitochondrial calcium. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. P6 - P7). CAMBRIDGE UNIV PRESS

Leyssens, A; Crompton, M; Duchen, MR; (1996) A role of the mitochondrial permeability transition pore in cell injury by reactive oxygen species in isolated rat cardiomyocytes. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. P109 - P110). CAMBRIDGE UNIV PRESS

Leyssens, A; Nowicky, AV; Patterson, L; Crompton, M; Duchen, MR; (1996) The relationship between mitochondrial state, ATP hydrolysis, [Mg2+], and [Ca2+](i) studied in isolated rat cardiomyocytes. J PHYSIOL-LONDON , 496 (1) 111 - 128.

Mojet, MH; Mills, E; Duchen, MR; (1996) Hypoxia-induced catecholamine secretion by adrenal chromaffin cells isolated from newborn rat is mediated by a fall in [ATP](i) and influx of extracellular Ca2+. In: JOURNAL OF PHYSIOLOGY-LONDON. (pp. P80 - P81). CAMBRIDGE UNIV PRESS

Mojet, MH; Mills, E; Duchen, MR; (1996) Hypoxia-induced catecholamine secretion in adrenal chromaffin cells isolated from newborn rat. PROG BIOPHYS MOL BIO , 65 PC101 - PC101.

Peuchen, S; Clark, JB; Duchen, MR; (1996) Mechanisms of intracellular calcium regulation in adult astrocytes. NEUROSCIENCE , 71 (3) 871 - 883.

Peuchen, S; Duchen, MR; Clark, JB; (1996) Modulation of the glutathione redox state in adult astrocytes. In: BIOCHEMICAL SOCIETY TRANSACTIONS. (pp. S449 - S449). PORTLAND PRESS

Peuchen, S; Duchen, MR; Clark, JB; (1996) Modulation of the glutathione redox state in adult astrocytes. Biochem Soc Trans , 24 (3) 449S - ?.

Peuchen, S; Duchen, MR; Clark, JB; (1996) Energy metabolism of adult astrocytes in vitro. NEUROSCIENCE , 71 (3) 855 - 870.

1995

LEYSSENS, A; NOWICKY, AV; PATTERSON, L; CROMPTON, M; DUCHEN, MR; (1995) CHANGES IN INTRACELLULAR MAGNESIUM AND ATP-REGULATED K+ CHANNEL ACTIVITY WITH CHANGING METABOLIC STATE IN ISOLATED RAT CARDIOMYOCYTES. J PHYSIOL-LONDON , 483P P9 - P10.

LEYSSENS, A; RASTOGHI, R; CRASKE, M; CROMPTON, M; DUCHEN, MR; (1995) TRANSIENT DEPOLARIZATIONS OF MITOCHONDRIA LOCALIZED TO DISCRETE AREAS OF SINGLE-RAT CARDIOMYOCYTES CAUSED BY FREE-RADICALS AND LOCAL CALCIUM-RELEASE - A MODEL FOR FREE RADICAL-INDUCED CELL INJURY. J PHYSIOL-LONDON , 487P P123 - P124.

MOJET, MH; MILLS, E; DUCHEN, MR; (1995) CHANGES IN MITOCHONDRIAL-FUNCTION, [CA2+](I) AND CATECHOLAMINE SECRETION IN RESPONSE TO HYPOXIA IN CHROMAFFIN CELLS DISSOCIATED FROM THE NEWBORN RAT ADRENAL. J PHYSIOL-LONDON , 487P P59 - P59.

NOWICKY, AV; DUCHEN, MR; (1995) INHIBITION OF MITOCHONDRIAL-FUNCTION INDUCES A CALCIUM-DEPENDENT POTASSIUM CURRENT IN DISSOCIATED RAT CA1 HIPPOCAMPAL-NEURONS. J PHYSIOL-LONDON , 487P P60 - P60.

PEARCE, RJ; DUCHEN, MR; (1995) ELECTROPHYSIOLOGICAL AND METABOLIC EFFECTS OF A CONVULSANT BARBITURATE ON DISSOCIATED MOUSE PRIMARY SENSORY NEURONS. J PHYSIOL-LONDON , 483 (2) 407 - 420.

SMITH, PA; DUCHEN, MR; ASHCROFT, FM; (1995) A FLUOROMETRIC AND AMPEROMETRIC STUDY OF CALCIUM AND SECRETION IN ISOLATED MOUSE PANCREATIC BETA-CELLS. PFLUG ARCH EUR J PHY , 430 (5) 808 - 818.

TERAKAWA, S; KUMAKURA, K; DUCHEN, MR; (1995) SPATIOTEMPORAL ANALYSIS OF QUANTAL SECRETORY EVENTS FROM SINGLE BOVINE ADRENAL CHROMAFFIN CELLS IN CULTURE. J PHYSIOL-LONDON , 487P P59 - P60.

1994

DUCHEN, MR; NOWICKY, AV; LEYSSENS, A; (1994) SIMULTANEOUS MEASUREMENTS OF MITOCHONDRIAL POTENTIAL AND NAD(P)H AUTOFLUORESCENCE FROM SINGLE ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON , 476P P2 - P3.

DUCHEN, MR; PEUCHEN, S; LEYSSENS, A; NOWICKY, AV; CLARK, JB; (1994) IMAGING MITOCHONDRIAL-FUNCTION IN SINGLE ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON , 475P P7 - P8.

LEYSSENS, A; DUCHEN, MR; (1994) CHANGES IN INTRACELLULAR FREE MAGNESIUM WITH ATP DEPLETION IN SINGLE ISOLATED RAT CARDIOMYOCYTES. J PHYSIOL-LONDON , 480P P90 - P90.

NOWICKY, AV; DUCHEN, MR; (1994) RELATIONSHIP BETWEEN MITOCHONDRIAL POTENTIAL AND INTRACELLULAR CALCIUM IN DISSOCIATED RAT HIPPOCAMPAL-NEURONS. J PHYSIOL-LONDON , 475P P148 - P148.

PEARCE, RJ; DUCHEN, MR; (1994) DIFFERENTIAL EXPRESSION OF MEMBRANE CURRENTS IN DISSOCIATED MOUSE PRIMARY SENSORY NEURONS. NEUROSCIENCE , 63 (4) 1041 - 1056.

PEUCHEN, S; CLARK, JB; DUCHEN, MR; (1994) CHARACTERIZATION OF [CA2+](I) TRANSIENTS INDUCED BY NUCLEOTIDE RECEPTOR ACTIVATION IN ASTROCYTES CULTURED FROM THE FOREBRAIN OF THE ADULT-RAT. J PHYSIOL-LONDON , 475P P106 - P106.

SMITH, P; DUCHEN, M; ASHCROFT, FM; (1994) VOLTAMMETRIC MONITORING OF 5-HT SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS. J PHYSIOL-LONDON , 475P P157 - P157.

1993

DUCHEN, MR; (1993) VOLTAMMETRIC DETECTION OF QUANTAL SECRETORY EVENTS FROM ISOLATED RAT PERITONEAL MAST-CELLS. J PHYSIOL-LONDON , 467 P2 - P2.

DUCHEN, MR; CROMPTON, M; PEUCHEN, S; NOWICKY, AV; (1993) THE USE OF A CARBOCYANINE DYE, JC-1, TO MONITOR CHANGES OF MITOCHONDRIAL POTENTIAL IN ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON , 473 P7 - P7.

DUCHEN, MR; MCGUINNESS, O; BROWN, LA; CROMPTON, M; (1993) ON THE INVOLVEMENT OF A CYCLOSPORINE-A SENSITIVE MITOCHONDRIAL PORE IN MYOCARDIAL REPERFUSION INJURY. CARDIOVASC RES , 27 (10) 1790 - 1794.

DUCHEN, MR; PEUCHEN, S; NOWICKY, A; (1993) CHANGES IN MITOCHONDRIAL-FUNCTION IN RESPONSE TO CHANGES IN CYTOSOLIC CA-2+ CONCENTRATION. In: BIOMEDICAL RESEARCH-TOKYO. (pp. 139 - 146). BIOMED RES FOUND Gold open access

DUCHEN, MR; SMITH, PA; ASHCROFT, FM; (1993) SUBSTRATE-DEPENDENT CHANGES IN MITOCHONDRIAL-FUNCTION, INTRACELLULAR FREE CALCIUM-CONCENTRATION AND MEMBRANE CHANNELS IN PANCREATIC BETA-CELLS. BIOCHEM J , 294 35 - 42.

DUCHEN, MR; SMITH, PA; ASHCROFT, FM; (1993) SUBSTRATE-DEPENDENT CHANGES IN MITOCHONDRIAL-FUNCTION, [CA-2+]I AND KATP CHANNELS IN MOUSE PANCREATIC BETA-CELLS INVITRO. J PHYSIOL-LONDON , 459 P266 - P266.

NOWICKY, AV; PEUCHEN, S; CLARK, JB; DUCHEN, MR; (1993) SIMULTANEOUS MEASUREMENTS OF INTRACELLULAR CALCIUM AND MITOCHONDRIAL POTENTIAL IN ISOLATED MAMMALIAN-CELLS. J PHYSIOL-LONDON , 473 P10 - P10.

PEUCHEN, S; CLARK, JB; DUCHEN, MR; (1993) CHANGES IN [CA2+](I) IN RESPONSE TO ATP IN ASTROCYTES CULTURED FROM THE FOREBRAIN OF THE ADULT-RAT. J PHYSIOL-LONDON , 473 P42 - P42.

PEUCHEN, S; DUCHEN, MR; CLARK, JB; (1993) MODULATION OF INTRACELLULAR CALCIUM IN CULTURED ADULT MAMMALIAN ASTROCYTES. J NEUROCHEM , 61 S44 - S44.

1992

DUCHEN, MR; (1992) CA2+-DEPENDENT CHANGES IN THE MITOCHONDRIAL ENERGETICS IN SINGLE DISSOCIATED MOUSE SENSORY NEURONS. BIOCHEM J , 283 41 - 50.

DUCHEN, MR; BISCOE, TJ; (1992) MITOCHONDRIAL-FUNCTION IN TYPE-I CELLS ISOLATED FROM RABBIT ARTERIAL CHEMORECEPTORS. J PHYSIOL-LONDON , 450 13 - 31.

DUCHEN, MR; BISCOE, TJ; (1992) RELATIVE MITOCHONDRIAL-MEMBRANE POTENTIAL AND [CA2+]I IN TYPE-I CELLS ISOLATED FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 450 33 - 61.

PEARCE, RJ; DUCHEN, MR; (1992) ACTIONS OF THE CONVULSANT BARBITURATE 5-(2-CYCLOHEXYLIDINE-ETHYL)-5-ETHYL BARBITURIC-ACID (CHEB) ON DISSOCIATED MOUSE SENSORY NEURONS. J PHYSIOL-LONDON , 446 P136 - P136.

1991

DUCHEN, MR; (1991) CALCIUM-INDUCED CHANGES IN MITOCHONDRIAL-FUNCTION IN SINGLE DISSOCIATED MOUSE NEURONS. J PHYSIOL-LONDON , 438 P206 - P206.

FARQUHARSON, D; DUCHEN, MR; PEARCE, RJ; BISCOE, TJ; (1991) APPARATUS FOR SIMULTANEOUS FLASH-PHOTOLYSIS AND MICROFLUORIMETRY. J PHYSIOL-LONDON , 438 P142 - P142.

TATHAM, PER; DUCHEN, MR; MILLAR, J; (1991) MONITORING EXOCYTOSIS FROM SINGLE MAST-CELLS BY FAST VOLTAMMETRY. PFLUG ARCH EUR J PHY , 419 (3-4) 409 - 414.

1990

BISCOE, TJ; DUCHEN, MR; (1990) MONITORING PO2 BY THE CAROTID CHEMORECEPTOR. NEWS PHYSIOL SCI , 5 229 - 233.

BISCOE, TJ; DUCHEN, MR; (1990) RESPONSES OF TYPE-I CELLS DISSOCIATED FROM THE RABBIT CAROTID-BODY TO HYPOXIA. J PHYSIOL-LONDON , 428 39 - 59.

BISCOE, TJ; DUCHEN, MR; (1990) CELLULAR BASIS OF TRANSDUCTION IN CAROTID CHEMORECEPTORS. AM J PHYSIOL , 258 (6) L271 - L278.

DUCHEN, MR; (1990) EFFECTS OF METABOLIC INHIBITION ON THE MEMBRANE-PROPERTIES OF ISOLATED MOUSE PRIMARY SENSORY NEURONS. J PHYSIOL-LONDON , 424 387 - 409.

DUCHEN, MR; BISCOE, TJ; (1990) CHANGES IN MITOCHONDRIAL-MEMBRANE POTENTIAL AND [CA-2+]I WITH HYPOXIA IN TYPE-I CELLS ISOLATED FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 426 P65 - P65.

DUCHEN, MR; BISCOE, TJ; VALDEOLMILLOS, M; (1990) BIOPHYSICAL STUDIES OF CELLS FROM THE CAROTID-BODY OF THE RABBIT. In: EYZAGUIRRE, C and FIDONE, SJ and FITZGERALD, RS and LAHIRI, S and MCDONALD, DM, (eds.) ARTERIAL CHEMORECEPTION. (pp. 31 - 43). SPRINGER-VERLAG

DUCHEN, MR; MILLAR, J; BISCOE, TJ; (1990) VOLTAMMETRIC MEASUREMENT OF CATECHOLAMINE RELEASE FROM ISOLATED RAT CHROMAFFIN CELLS. J PHYSIOL-LONDON , 426 P5 - P5.

DUCHEN, MR; PEARCE, RJ; BISCOE, TJ; (1990) USE OF MICROFLUORIMETRY TO MONITOR MITOCHONDRIAL-MEMBRANE POTENTIAL IN SINGLE DISSOCIATED MAMMALIAN-CELLS. J PHYSIOL-LONDON , 426 P2 - P2.

DUCHEN, MR; VALDEOLMILLOS, M; ONEILL, SC; EISNER, DA; (1990) EFFECTS OF METABOLIC BLOCKADE ON THE REGULATION OF INTRACELLULAR CALCIUM IN DISSOCIATED MOUSE SENSORY NEURONS. J PHYSIOL-LONDON , 424 411 - 426.

PEARCE, RJ; DUCHEN, MR; (1990) DIFFERENTIAL EXPRESSION OF MEMBRANE CURRENTS IN ISOLATED MOUSE PRIMARY SENSORY NEURONS. J PHYSIOL-LONDON , 425 P70 - P70.

1989

BISCOE, TJ; DUCHEN, MR; (1989) HYPOXIA RAISES INTRACELLULAR CALCIUM IN TYPE-I CELLS ISOLATED FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 418 P128 - P128.

BISCOE, TJ; DUCHEN, MR; (1989) ELECTROPHYSIOLOGICAL RESPONSES OF DISSOCIATED TYPE-I CELLS OF THE RABBIT CAROTID-BODY TO CYANIDE. J PHYSIOL-LONDON , 413 447 - 468.

BISCOE, TJ; DUCHEN, MR; EISNER, DA; ONEILL, SC; VALDEOLMILLOS, M; (1989) MEASUREMENTS OF INTRACELLULAR CA-2+ IN DISSOCIATED TYPE-I CELLS OF THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 416 421 - 434.

BISCOE, TJ; DUCHEN, MR; FRY, JP; RICKETS, C; (1989) PURIFICATION AND ACTIONS OF ENDOGENOUS BENZODIAZEPINE-LIKE IMMUNOREACTIVITY ISOLATED FROM THE BRAIN OF THE MOUSE. J PHYSIOL-LONDON , 415 P50 - P50.

DUCHEN, MR; (1989) GABAA RESPONSES OF DISSOCIATED MOUSE NEURONS ARE ATTENUATED BY METABOLIC BLOCKADE. J PHYSIOL-LONDON , 415 P48 - P48.

DUCHEN, MR; PEARCE, RJ; (1989) A PREPARATION OF NEURONS FRESHLY DISSOCIATED FROM MOUSE DORSAL-ROOT GANGLIA FOR ELECTROPHYSIOLOGICAL STUDY. J PHYSIOL-LONDON , 415 P6 - P6.

1988

BISCOE, TJ; DUCHEN, MR; EISNER, DA; ONEILL, SC; VALDEOLMILLOS, M; (1988) THE EFFECTS OF GLUCOSE REMOVAL AND CYANIDE ON INTRACELLULAR CA-2+ IN ISOLATED, SINGLE-MOUSE DORSAL-ROOT GANGLION-CELLS. J PHYSIOL-LONDON , 401 P60 - P60.

BISCOE, TJ; DUCHEN, MR; EISNER, DA; ONEILL, SC; VALDEOLMILLOS, M; (1988) CYANIDE INCREASES [CA-2+]I IN ISOLATED TYPE-I CELLS FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 396 P99 - P99.

BISCOE, TJ; DUCHEN, MR; KIRBY, GC; PATTERSON, DL; PONTE, J; (1988) VOLTAGE-CLAMP STUDY OF THE EFFECTS OF CYANIDE ON DISSOCIATED TYPE-I CELLS OF THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 396 P178 - P178.

DUCHEN, MR; CADDY, KWT; KIRBY, GC; PATTERSON, DL; PONTE, J; BISCOE, TJ; (1988) BIOPHYSICAL STUDIES OF THE CELLULAR-ELEMENTS OF THE RABBIT CAROTID-BODY. NEUROSCIENCE , 26 (1) 291 - 311.

DUCHEN, MR; SOMJEN, GG; (1988) EFFECTS OF CYANIDE AND LOW GLUCOSE ON THE MEMBRANE CURRENTS OF DISSOCIATED MOUSE PRIMARY SENSORY NEURONS. J PHYSIOL-LONDON , 401 P61 - P61.

1987

BISCOE, TJ; CADDY, KWT; DUCHEN, MR; KIRBY, GC; PATTERSON, DL; PONTE, J; (1987) PREPARATION AND IDENTIFICATION OF FRESHLY DISSOCIATED CELLS FROM THE RABBIT CAROTID-BODY FOR ELECTROPHYSIOLOGICAL STUDY. J PHYSIOL-LONDON , 392 P11 - P11.

BISCOE, TJ; DUCHEN, MR; KIRBY, GC; PATTERSON, DL; PONTE, J; (1987) ELECTROPHYSIOLOGICAL CHARACTERIZATION OF FRESHLY DISSOCIATED TYPE-I CELLS FROM THE RABBIT CAROTID-BODY. J PHYSIOL-LONDON , 392 P36 - P36.

BISCOE, TJ; DUCHEN, MR; PATTERSON, DL; (1987) DUAL ACTIONS OF GLYCINE ON DISSOCIATED MOUSE SPINAL NEURONS. J PHYSIOL-LONDON , 382 P133 - P133.

YU, YB; DUCHEN, MR; BISCOE, TJ; (1987) PRIMARY AFFERENT TERMINAL EXCITABILITY IN THE NORMAL AND SPASTIC MUTANT MOUSE SPINAL-CORD. EUR J PHARMACOL , 141 (3) 371 - 382.

1986

BISCOE, TJ; DUCHEN, MR; (1986) SYNAPTIC PHYSIOLOGY OF SPINAL MOTONEURONS OF NORMAL AND SPASTIC MICE - AN INVITRO STUDY. J PHYSIOL-LONDON , 379 275 - 292.

BISCOE, TJ; DUCHEN, MR; PATTERSON, L; (1986) VOLTAGE-CLAMP STUDY OF ACUTELY DISSOCIATED MOUSE SPINAL NEURONS. J PHYSIOL-LONDON , 377 P10 - P10.

DUCHEN, MR; (1986) EXCITATION OF MOUSE MOTONEURONS BY GABA-MEDIATED PRIMARY AFFERENT DEPOLARIZATION. BRAIN RES , 379 (1) 182 - 187.

1985

BISCOE, TJ; DUCHEN, MR; (1985) ACTIONS AND INTERACTIONS OF GABA AND BENZODIAZEPINES IN THE MOUSE HIPPOCAMPAL SLICE. Q J EXP PHYSIOL CMS , 70 (3) 313 - 328.

BISCOE, TJ; DUCHEN, MR; (1985) THE ANION SELECTIVITY OF GABA-MEDIATED POST-SYNAPTIC POTENTIALS IN MOUSE HIPPOCAMPAL CELLS. Q J EXP PHYSIOL CMS , 70 (3) 305 - 312.

BISCOE, TJ; DUCHEN, MR; (1985) AN INTRACELLULAR STUDY OF DENTATE, CA1 AND CA3 NEURONS IN THE MOUSE HIPPOCAMPAL SLICE. Q J EXP PHYSIOL CMS , 70 (2) 189 - 202.

BISCOE, TJ; DUCHEN, MR; WILSON, MGA; (1985) USE OF THE RML MICROCOMPUTER 380Z FOR ONLINE TESTING OF PRIMARY AFFERENT TERMINAL EXCITABILITY IN THE MOUSE SPINAL-CORD INVITRO. J PHYSIOL-LONDON , 365 (AUG) P2 - P2.

DUCHEN, MR; (1985) EXCITATION OF MOTONEURONES BY GABA-MEDIATED PRIMARY AFFERENT DEPOLARIZATION IN THE MOUSE SPINAL-CORD INVITRO. J PHYSIOL-LONDON , 364 (JUL) P45 - P45.

DUCHEN, MR; BURTON, NR; BISCOE, TJ; (1985) AN INTRACELLULAR STUDY OF THE INTERACTIONS OF N-METHYL-DL-ASPARTATE WITH KETAMINE IN THE MOUSE HIPPOCAMPAL SLICE. BRAIN RES , 342 (1) 149 - 153.

1983

BISCOE, TJ; DUCHEN, MR; PASCOE, JE; (1983) GABA BENZODIAZEPINE INTERACTIONS IN THE MOUSE HIPPOCAMPAL SLICE. J PHYSIOL-LONDON , 341 (AUG) P8 - P9.

BISCOE, TJ; DUCHEN, MR; PASCOE, JE; (1983) USE OF THE RML-380Z MICROCOMPUTER FOR ONLINE MEASUREMENT OF INPUT RESISTANCE OF CELLS IN THE MOUSE HIPPOCAMPAL SLICE. J PHYSIOL-LONDON , 341 (AUG) P2 - P3.

1982

BISCOE, TJ; CRUNELLI, V; DUCHEN, MR; FORDA, S; (1982) THE MOUSE HIPPOCAMPAL SLICE - INTRACELLULAR-RECORDINGS FROM PYRAMIDAL NEURONS AND DENTATE GRANULE CELLS. J PHYSIOL-LONDON , 328 (JUL) P5 - P5.

1980

DUCHEN, MR; MCNEILLY, AS; (1980) HYPER-PROLACTINEMIA AND LONG-TERM LACTATIONAL AMENORRHEA. CLIN ENDOCRINOL , 12 (6) 621 - 627.

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