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Prof William McKenna

  • Telephone:

    0203 456 4502

  • Fax:

    0203 456 4901

  • Email:

    w.mckenna@ucl.ac.uk

  • Address:

    The Heart Hospital 16-18 Westmoreland Street,
    London,
    W1G 8PH

  • Appointments:

    Professor of Cardiology, Centre for Cardiology in the Young, Institute of Cardiovascular Science

Research Summary

At UCL there are 22 centres of cardiovascular related medicine. At the recommendation of the recent biomedicine review the Institute of Cardiovascular Science (ICS) has been established to enable coordination of research, training, funding and governance across UCL and its affiliated hospitals. Research themes from ‘Birth to Grave’ have been mapped for ICS West (UCLH) and ICS East (GOSH) with the overall aim to translate scientific discovery and innovation into measurable improvements in cardiovascular health.

Research Activities

  • Paediatric Neurology

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Captur G,Muthurangu V,Cook C,Flett AS,Wilson R,Barison A,Sado DM,Anderson S,McKenna WJ,Mohun TJ,Elliott PM,Moon JC (2013) Quantification of left ventricular trabeculae using fractal analysis. J Cardiovasc Magn Reson, 15(1), 36. 10.1186/1532-429X-15-36.
  2. Jacoby DL,DePasquale EC,McKenna WJ (2013) Hypertrophic cardiomyopathy: diagnosis, risk stratification and treatment CANADIAN MEDICAL ASSOCIATION JOURNAL, 185(2), 127 - 134. 10.1503/cmaj.120138.
  3. Groeneweg JA,van der Zwaag PA,Jongbloed JDH,Cox MGPJ,Vreeker A,de Boer RA,van der Heijden JF,van Veen TAB,McKenna WJ,van Tintelen JP,Dooijes D,Hauer RNW (2013) Left-dominant arrhythmogenic cardiomyopathy in a large family: Associated desmosomal or nondesmosomal genotype? HEART RHYTHM, 10(4), 548 - 559. 10.1016/j.hrthm.2012.12.020.
  4. Hodgkinson KA,Connors SP,Merner N,Haywood A,Young T-L,McKenna WJ,Gallagher B,Curtis F,Bassett AS,Parfrey PS (2013) The natural history of a genetic subtype ofarrhythmogenic right ventricular cardiomyopathy caused by a p.S358L mutation in TMEM43 CLINICAL GENETICS, 83(4), 321 - 331. 10.1111/j.1399-0004.2012.01919.x.
  5. O'Mahony C,Tome-Esteban M,Lambiase PD,Pantazis A,Dickie S,McKenna WJ,Elliott PM (2013) A validation study of the 2003 American College of Cardiology/European Society of Cardiology and 2011 American College of Cardiology Foundation/American Heart Association risk stratification and treatment algorithms for sudden cardiac death in patients with hypertrophic cardiomyopathy. Heart, 99(8), 534 - 541. 10.1136/heartjnl-2012-303271.
  6. Quarta G,Husain SI,Flett AS,Sado DM,Chao CY,Tomé Esteban MT,McKenna WJ,Pantazis A,Moon JC (2013) Arrhythmogenic right ventricular cardiomyopathy mimics: role of cardiovascular magnetic resonance. J Cardiovasc Magn Reson, 15, 16. 10.1186/1532-429X-15-16.
  7. Lopes LR,Zekavati A,Syrris P,Hubank M,Giambartolomei C,Dalageorgou C,Jenkins S,McKenna W,Uk10k Consortium ,Plagnol V,Elliott PM (2013) Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing. J Med Genet, 50(4), 228 - 239. 10.1136/jmedgenet-2012-101270.
  8. Haywood AF,Merner ND,Hodgkinson KA,Houston J,Syrris P,Booth V,Connors S,Pantazis A,Quarta G,Elliott P,McKenna W,Young TL (2013) Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada. Eur Heart J, 34(13), 1002 - 1011. 10.1093/eurheartj/ehs383.
  9. Coats CJ,Gallagher MJ,Foley M,O'Mahony C,Critoph C,Gimeno J,Dawnay A,McKenna WJ,Elliott PM (2013) Relation between serum N-terminal pro-brain natriuretic peptide and prognosis in patients with hypertrophic cardiomyopathy. Eur Heart J. 10.1093/eurheartj/eht070.
  10. Bayliss CR,Jacques AM,Leung M-C,Ward DG,Redwood CS,Gallon CE,Copeland O,McKenna WJ,dos Remedios C,Marston SB,Messer AE (2013) Myofibrillar Ca2+ sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T CARDIOVASCULAR RESEARCH, 97(3), 500 - 508. 10.1093/cvr/cvs322.
  11. Caforio ALP,Zachara E,Re F,Baratta P,Schiavo A,Thiene G,Iliceto S,Syrris P,McKenna WJ (2012) Involvement of autoimmunity in arrhythmogenic right ventricular cardiomyopathy: serum anti-intercalated disk autoantibodies are associated with desmosomal gene mutations EUROPEAN HEART JOURNAL, 33, 47 - 48.
  12. O'Mahony C,Lambiase PD,Quarta G,Cardona M,Calcagnino M,Tsovolas K,Al-Shaikh S,Rahman SM,Arnous S,Jones S,McKenna W,Elliott P (2012) The long-term survival and the risks and benefits of implantable cardioverter defibrillators in patients with hypertrophic cardiomyopathy. Heart, 98(2), 116 - 125. 10.1136/hrt.2010.217182.
  13. Sen-Chowdhry S,Jacoby D,McKenna WJ (2012) The implications of inheritance for clinical management. Circ Cardiovasc Genet, 5(4), 467 - 476. 10.1161/CIRCGENETICS.110.959361.
  14. Moon JC,McKenna WJ (2012) Myocardial crypts: a prephenotypic marker of hypertrophic cardiomyopathy? Circ Cardiovasc Imaging, 5(4), 431 - 432. 10.1161/CIRCIMAGING.112.975888.
  15. Kaski JP,Syrris P,Shaw A,Alapi KZ,Cordeddu V,Esteban MT,Jenkins S,Ashworth M,Hammond P,Tartaglia M,McKenna WJ,Elliott PM (2012) Prevalence of sequence variants in the RAS-mitogen activated protein kinase signaling pathway in pre-adolescent children with hypertrophic cardiomyopathy. Circ Cardiovasc Genet, 5(3), 317 - 326. 10.1161/CIRCGENETICS.111.960468.
  16. Jacoby DL,DePasquale EC,Lour O,Pomianowski P,McKenna WJ (2012) Familial Dilated Cardiomyopathy (FDCM) Prevalence in End-Stage Non-Ischemic Heart Failure (ESHF) JOURNAL OF HEART AND LUNG TRANSPLANTATION, 31(4), S52 - S52.
  17. DePasquale EC,Dries D,McKenna WJ,Jacoby DL (2012) Outcomes of Familial Dilated Cardiomyopathy (FDCM) Post Heart Transplant (HT) JOURNAL OF HEART AND LUNG TRANSPLANTATION, 31(4), S137 - S138.
  18. Sen-Chowdhry S,McKenna WJ (2012) Sudden death from genetic and acquired cardiomyopathies. Circulation, 125(12), 1563 - 1576. 10.1161/CIRCULATIONAHA.111.025528.
  19. Pasquale F,Syrris P,Kaski JP,Mogensen J,McKenna WJ,Elliott P (2012) Long-term outcomes in hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene Circulation. Cardiovascular Genetics, 5(1), 10 - 17.
  20. Bayés de Luna A,Brugada J,Baranchuk A,Borggrefe M,Breithardt G,Goldwasser D,Lambiase P,Riera AP,Garcia-Niebla J,Pastore C,Oreto G,McKenna W,Zareba W,Brugada R,Brugada P (2012) Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report. J Electrocardiol, 45(5), 433 - 442. 10.1016/j.jelectrocard.2012.06.004.
  21. Coats CJ,Patel A,Mist B,Tome M,Dickie S,McKenna WJ,Elliott PM (2012) Sub-maximal exercise parameters are important prognostic markers in hypertrophic cardiomyopathy EUROPEAN HEART JOURNAL, 33, 288 - 288.
  22. O'Mahony C,Tome-Esteban M,Pantazis A,Dickie S,McKenna W,Elliott P (2012) Validation of the 2003 ACC/ESC guidelines on the risk stratification of sudden cardiac death in hypertrophic cardiomyopathy EUROPEAN HEART JOURNAL, 33, 195 - 195.
  23. O'Mahony C,Rahman S,Biagini E,Rappezzi C,Monseratt L,Gimeno JR,Limongelli G,Anastasakis A,McKenna W,Elliott P (2012) A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy: a proof of concept study EUROPEAN HEART JOURNAL, 33, 364 - 364.
  24. Sen-Chowdhry S,Tomé Esteban MT,McKenna WJ (2012) Insights and challenges in hypertrophic cardiomyopathy, 2012. Herzschrittmacherther Elektrophysiol, 23(3), 174 - 185. 10.1007/s00399-012-0227-5.
  25. Lambiase PD,Nunn LM,Bhar-Amato J,Lowe MD,Macfarlane PW,Rogers P,McKenna WJ,Elliott PM (2012) Reply. J Am Coll Cardiol, 59(18), 1660 - 1661. 10.1016/j.jacc.2012.01.031.
  26. Ramon Gimeno J,Teresa Tome M,McKenna WJ (2012) Alcohol Septal Ablation in Hypertrophic Cardiomyopathy: An Opportunity to Be Taken REVISTA ESPANOLA DE CARDIOLOGIA, 65(4), 314 - 318. 10.1016/j.rec.2011.11.014.
  27. Sniderman JD,Sado DM,Sniderman AD,McKenna WJ (2012) Evaluation of suspected right ventricular pathology in the athlete. Prog Cardiovasc Dis, 54(5), 397 - 406. 10.1016/j.pcad.2012.01.005.
  28. Jacoby D,McKenna WJ (2012) Genetics of inherited cardiomyopathy EUROPEAN HEART JOURNAL, 33(3), 296 - U163. 10.1093/eurheartj/ehr260.
  29. Page SP,Kounas S,Syrris P,Christiansen M,Frank-Hansen R,Andersen PS,Elliott PM,McKenna WJ (2012) Cardiac myosin binding protein-C mutations in families with hypertrophic cardiomyopathy: disease expression in relation to age, gender, and long term outcome. Circ Cardiovasc Genet, 5(2), 156 - 166. 10.1161/CIRCGENETICS.111.960831.
  30. Gomes J,Finlay M,Ahmed AK,Ciaccio EJ,Asimaki A,Saffitz JE,Quarta G,Nobles M,Syrris P,Chaubey S,McKenna WJ,Tinker A,Lambiase PD (2012) Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J, 33(15), 1942 - 1953. 10.1093/eurheartj/ehr472.
  31. Quarta G,Syrris P,Ashworth M,Jenkins S,Zuborne Alapi K,Morgan J,Muir A,Pantazis A,McKenna WJ,Elliott PM (2012) Mutations in the Lamin A/C gene mimic arrhythmogenic right ventricular cardiomyopathy. Eur Heart J, 33(9), 1128 - 1136. 10.1093/eurheartj/ehr451.
  32. O'Mahony C,Lambiase PD,Rahman SM,Cardona M,Calcagnino M,Quarta G,Tsovolas K,Al-Shaikh S,McKenna W,Elliott P (2012) The relation of ventricular arrhythmia electrophysiological characteristics to cardiac phenotype and circadian patterns in hypertrophic cardiomyopathy. Europace, 14(5), 724 - 733. 10.1093/europace/eur362.
  33. Gehmlich K,Syrris P,Reimann M,Asimaki A,Ehler E,Evans A,Quarta G,Pantazis A,Saffitz JE,McKenna WJ (2012) Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele. Cardiovasc Pathol, 21(4), 275 - 282. 10.1016/j.carpath.2011.09.005.
  34. Sado DM,Flett AS,Banypersad SM,White SK,Maestrini V,Quarta G,Lachmann RH,Murphy E,Mehta A,Hughes DA,McKenna WJ,Taylor AM,Hausenloy DJ,Hawkins PN,Elliott PM,Moon JC (2012) Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. Heart, 98(19), 1436 - 1441. 10.1136/heartjnl-2012-302346.
  35. McKenna W,Elliott P (2011) Diseases of the myocardium and endocardium, 318 - 333.
  36. Tripathi S,Schultz I,Becker E,Montag J,Borchert B,Francino A,Navarro-Lopez F,Perrot A,Oezcelik C,Osterziel K-J,McKenna WJ,Brenner B,Kraft T (2011) Unequal allelic expression of wild-type and mutated beta-myosin in familial hypertrophic cardiomyopathy BASIC RESEARCH IN CARDIOLOGY, 106(6), 1041 - 1055. 10.1007/s00395-011-0205-9.
  37. Nunn LM,Bhar-Amato J,Lowe MD,Macfarlane PW,Rogers P,McKenna WJ,Elliott PM,Lambiase PD (2011) Prevalence of J-point elevation in sudden arrhythmic death syndrome families. J Am Coll Cardiol, 58(3), 286 - 290. 10.1016/j.jacc.2011.03.028.
  38. Caforio AL,Zachara E,Re F,Baratta P,Bagato F,Thiene G,Iliceto S,Syrris P,McKenna WJ (2011) Serum Anti-Intercalated Disk Autoantibodies in Arrhythmogenic Right Ventricular Cardiomyopathy are Autoimmune Markers Associated with Pathogenic Desmosomal Mutations CIRCULATION, 124(21).
  39. Asimaki A,Tandri H,Duffy ER,Winterfield JR,Mackey-Bojack S,Picken MM,Cooper LT,Wilber DJ,Marcus FI,Basso C,Thiene G,Tsatsopoulou A,Protonotarios N,Stevenson WG,McKenna WJ,Gautam S,Remick DG,Calkins H,Saffitz JE (2011) Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic Links to Arrhythmogenic Right Ventricular Cardiomyopathy CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 4(5), 743 - U240. 10.1161/CIRCEP.111.964890.
  40. Gehmlich K,Syrris P,Peskett E,Evans A,Ehler E,Asimaki A,Anastasakis A,Tsatsopoulou A,Vouliotis AI,Stefanadis C,Saffitz JE,Protonotarios N,McKenna WJ (2011) Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Cardiovasc Res, 90(1), 77 - 87. 10.1093/cvr/cvq353.
  41. Ackerman MJ,Priori SG,Willems S,Berul C,Brugada R,Calkins H,Camm AJ,Ellinor PT,Gollob M,Hamilton R,Hershberger RE,Judge DP,Le Marec H,McKenna WJ,Schulze-Bahr E,Semsarian C,Towbin JA,Watkins H,Wilde A,Wolpert C,Zipes DP (2011) HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies EUROPACE, 13(8), 1077 - 1109. 10.1093/europace/eur245.
  42. Ashrafian H,McKenna WJ,Watkins H (2011) Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy CIRC RES, 109(1), 86 - 96. 10.1161/CIRCRESAHA.111.242974.
  43. Quarta G,Muir A,Pantazis A,Syrris P,Gehmlich K,Garcia-Pavia P,Ward D,Sen-Chowdhry S,Elliott PM,McKenna WJ (2011) Familial evaluation in arrhythmogenic right ventricular cardiomyopathy: impact of genetics and revised task force criteria. Circulation, 123(23), 2701 - 2709. 10.1161/CIRCULATIONAHA.110.976936.
  44. Desai MY,Ommen SR,McKenna WJ,Lever HM,Elliott PM (2011) Imaging phenotype versus genotype in hypertrophic cardiomyopathy. Circ Cardiovasc Imaging, 4(2), 156 - 168. 10.1161/CIRCIMAGING.110.957936.
  45. Gehmlich K,Lambiase PD,Asimaki A,Ciaccio EJ,Ehler E,Syrris P,Saffitz JE,McKenna WJ (2011) A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Heart Rhythm, 8(5), 711 - 718. 10.1016/j.hrthm.2011.01.010.
  46. Ackerman MJ,Priori SG,Willems S,Berul C,Brugada R,Calkins H,Camm AJ,Ellinor PT,Gollob M,Hamilton R,Hershberger RE,Judge DP,Le Marec H,McKenna WJ,Schulze-Bahr E,Semsarian C,Towbin JA,Watkins H,Wilde A,Wolpert C,Zipes DP (2011) HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies HEART RHYTHM, 8(8), 1308 - 1339. 10.1016/j.hrthm.2011.05.020.
  47. Puntmann VO,Yap YG,McKenna W,Camm AJ (2010) Significance of Maximal and Regional Left Ventricular Wall Thickness in Association With Arrhythmic Events in Patients With Hypertrophic Cardiomyopathy CIRC J, 74(3), 531 - 537. 10.1253/circj.CJ-09-0723.
  48. Corrado D,Pelliccia A,Heidbuchel H,Sharma S,Link M,Basso C,Biffi A,Buja G,Delise P,Gussac I,Anastasakis A,Borjesson M,Bjornstad HH,Carre F,Deligiannis A,Dugmore D,Fagard R,Hoogsteen J,Mellwig KP,Panhuyzen-Goedkoop N,Solberg E,Vanhees L,Drezner J,Estes NAM,Iliceto S,Maron BJ,Peidro R,Schwartz PJ,Stein R,Thiene G,Zeppilli P,McKenna WJ,European Assoc Cardiovasc Preventi ,European Soc Cardiology (2010) Recommendations for interpretation of 12-lead electrocardiogram in the athlete EUR HEART J, 31(2), 243 - 259. 10.1093/eurheartj/ehp473.
  49. Sen-Chowdhry S,McKenna WJ (2010) Reconciling the protean manifestations of arrhythmogenic cardiomyopathy. Circ Arrhythm Electrophysiol, 3(6), 566 - 570. 10.1161/CIRCEP.110.960237.
  50. O'Hanlon R,Grasso A,Roughton M,Moon JC,Clark S,Wage R,Webb J,Kulkarni M,Dawson D,Sulaibeekh L,Chandrasekaran B,Bucciarelli-Ducci C,Pasquale F,Cowie MR,McKenna WJ,Sheppard MN,Elliott PM,Pennell DJ,Prasad SK (2010) Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol, 56(11), 867 - 874. 10.1016/j.jacc.2010.05.010.

Qualifications

  • 1974: Doctor of Medicine, McGill University
  • 1969: Bachelor of Arts, Yale University
  • /: Doctor of Science, Not stated