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Prof Lucy Wedderburn

Contact
Research
Publications
Biography
Additional

Email:
l.wedderburn@ucl.ac.uk
Address:
653 Institute of Child Health 30 Guilford Street,
London,
WC1N1EH
Appointments:

Professor of Paediatric Rheumatology, ICH - Rheumatology Unit, Dept of Infection & Immunity

Summary

Undergraduate: Cambridge University (final year studies in Immunology and Virologyt)

Medical training: Royal London Hospital

Core clinical training: London

PhD: Cancer Research UK/UCL

Post doctoral Fellowship (EMBO) to work in Immunology, Stanford University USA

Wellcome Trust Fellowship : UCL

UCL Faculty position since 2000

Research Summary

My research interests are T cell immunology, immune regulation and muscle biology. My lab group has a major focus upon human T cell responses and immune regulation, in particular the autoimmune conditions of childhood, including Juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyositis (JDM). We are interested in the mechanisms which allow survival and expansion of inflammatory T cells within the joint, the control of their production of cytokines and chemokines, and their contribution to disease. In tandem we study immune regulation and how this influences disease course and phenotype in JIA .

I am also Director of the Arthritis Research UK Centre for Adolescent Rheumatology, a partnership between ICH, UCL (Medicine), GOSH and UCLH which aims to promote and develop research in Adolescent Rheumatology.

Childhood arthritis has proved an excellent model in which to study the balance between activation and regulation in the immune system. We have shown that highly proinflammatory cells, Th17 cells, are more abundant in patients with mild forms of arthritis than those with the more severe disease type, and that Treg and Th17 cells exist in a reciprocal relationship in the joint. We have generated evidence for 'plasticity' of Th17 cells at the inflamed site. More recently we have identified a novel set of regulatory cells, defined by expression of CD161 that are also pro inflammatory.

These data led to our study to reveal mechanistic differences between two clinical groups of patients, known as persistent and extended oligoarticular JIA. We have found biological differences of gene expression, cell frequency and phenotype between these two disease courses, which pre date the clinical severity phenotype. The group leads a major study, CHARMS (Childhood Arthritis Response to Medication Study) which aims to define the factors which influence the response of children with JIA to the drugs methotrexate (MTX) or anti tumour necrosis factor (TNF). This interdisciplinary study has generated genetic, psychological and immunological data linked to carefully defined clinical response phenotypes, to understand the mechanisms of response to MTX, or the reasons for a failure of efficacy of MTX in JIA. We have just completed a genome wide association study ( GWAS) of response to MTX in JIA.

We also have a major interest in the pathology of muscle damage in childhood inflammatory myositis. This work is closely linked to our work through the Juvenile Dermatomyositis (JDM) Cohort and Biomarker Study and the Juvenile Dermatomyositis Research Centre see http://www.ucl.ac.uk/ich/research-ich/rheumatology-unit/research

Our recent projects have included biology of muscle stem cells (satellite cells), novel autoantibodies in JDM and an analysis of the role of MRP/S100 proteins in childhood myositis.

Research Activities

Gene expression profiling/genomics
Immunopathogenesis of paediatric autoimmune diseas
Inflammatory conditions of the gastrointestinal tract
JDM vasculopathy
JIA genetics
Lentiviral vector delivery of immune modulatory molecules
Muscle stem cell work
RANK/RANKL study
Response to MTX in JIA
characterisation of the genetic and immunological

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

Hinks A,Cobb J,Marion MC,Prahalad S,Sudman M,Bowes J,Martin P,Comeau ME,Sajuthi S,Andrews R,Brown M,Chen WM,Concannon P,Deloukas P,Edkins S,Eyre S,Gaffney PM,Guthery SL,Guthridge JM,Hunt SE,James JA,Keddache M,Moser KL,Nigrovic PA,Onengut-Gumuscu S,Onslow ML,Rosé CD,Rich SS,Steel KJ,Wakeland EK,Wallace CA,Wedderburn LR,Woo P,Boston Children's JIA Registry ,British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group ,Childhood Arthritis Prospective Study (CAPS) ,Childhood Arthritis Response to Medication Study (CHARMS) ,German Society for Pediatric Rheumatology (GKJR) ,JIA Gene Expression Study ,NIAMS JIA Genetic Registry ,TREAT Study ,United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC) ,Bohnsack JF,Haas JP,Glass DN,Langefeld CD,Thomson W,Thompson SD (2013) Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet. 10.1038/ng.2614.
Moncrieffe H,Ursu S,Holzinger D,Patrick F,Kassoumeri L,Wade A,Roth J,Wedderburn LR (2013) A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein. Rheumatology (Oxford). 10.1093/rheumatology/ket152.
Tansley SL,McHugh NJ,Wedderburn LR (2013) Adult and juvenile dermatomyositis: Are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms? Arthritis Research & Therapy.
Tansley SL,McHugh NJ,Wedderburn LR (2013) Adult and juvenile dermatomyositis: Are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms? Arthritis Research and Therapy, 15(2).
Sallum AM,Varsani H,Holton JL,Marie SK,Wedderburn LR (2013) Morphometric analyses of normal pediatric brachial biceps and quadriceps muscle tissue. Histol Histopathol, 28(4), 525 - 530.
Jethwa H,Jacques TS,Gunny R,Wedderburn LR,Pilkington C,Manzur AY (2013) Limb girdle muscular dystrophy type 2B masquerading as inflammatory myopathy: case report. Pediatr Rheumatol Online J, 11(1), 19. 10.1186/1546-0096-11-19.
Pesenacker AM,Bending D,Ursu S,Wu Q,Nistala K,Wedderburn LR (2013) CD161 defines the subset of FoxP3+ T cells capable of producing pro-inflammatory cytokines. Blood, e-pub. 10.1182/blood-2012-08-443473.
McErlane F,Beresford M,Baildam E,Chieng SEA,Davidson J,Foster H,Gardner-Medwin J,Lunt M,Wedderburn LR,Thomson W,Hyrich KL (2012) MINIMAL DISEASE ACTIVITY IN A CLINICAL COHORT OF CHILDREN WITH JIA: RESULTS FROM THE CHILDHOOD ARTHRITIS PROSPECTIVE STUDY RHEUMATOLOGY, 51, 3 - 3.
Martin N,Krol P,Smith S,Beard L,Pilkington CA,Davidson J,Wedderburn LR,Juvenile Dermatomyositis Research Group (JDRG) (2012) Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study. Arthritis Care Res (Hoboken), 64(11), 1665 - 1672. 10.1002/acr.21753.
Wedderburn LR,Nistala K (2012) Immunology and Aetiology of Juvenile Idiopathic arthritis.
Gerss J,Roth J,Holzinger D,Ruperto N,Wittkowski H,Frosch M,Wulffraat N,Wedderburn L,Stanevicha V,Mihaylova D,Harjacek M,Len C,Toppino C,Masi M,Minden K,Saurenmann T,Uziel Y,Vesely R,Apaz MT,Kuester R-M,Elorduy MJR,Burgos-Vargas R,Ioseliani M,Magni-Manzoni S,Unsal E,Anton E,Balogh Z,Hagelberg S,Mazur-Zielinska H,Tauber T,Martini A,Foel D (2012) Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: A comparative study Annals of the Rheumatic Diseases.
Martin N,Li CK,Wedderburn LR (2012) Juvenile dermatomyositis: New insights and new treatment strategies Therapeutic Advances in Musculoskeletal Disease, 4(1), 41 - 50.
Ye Y,Van Zyl B,Varsani H,Wedderburn LR,Ramanan A,Gillespie KM (2012) Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis Rheumatology (United Kingdom), 51(6), 987 - 991.
Holzinger D,Frosch M,Kastrup A,Prince FHM,Otten MH,Van Suijlekom-Smit LWA,Ten Cate R,Hoppenreijs EPAH,Hansmann S,Moncrieffe H,Ursu S,Wedderburn LR,Roth J,Foell D,Wittkowski H (2012) The toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis Annals of the Rheumatic Diseases, 71(6), 974 - 980.
Omoyinmi E,Forabosco P,Hamaoui R,Bryant A,Hinks A,Ursu S,Wedderburn LR,Thomson W,Lewis CM,Woo P (2012) Association of the IL-10 Gene Family Locus on Chromosome 1 with Juvenile Idiopathic Arthritis (JIA) PLoS ONE, 7(10).
Hinks A,Cobb J,Sudman M,Eyre S,Martin P,Flynn E,Packham J,Barton A,Worthington J,Langefeld CD,Glass DN,Thompson SD,Thomson W,Baildam E,Brown L,Buckley J,Chieng A,Davidson J,Eltringham M,Foster H,Friswell M,Gardner-Medwin J,Gilbert P,Hyrich K,Jones J,Lal S,Lay M,Lydon C,Meijer A,Price V,Sim J,Todd M,Ward P,Wedderburn L,Bowes J,Martin S,Robinson JI,Morgan AW,Emery P,Wilson AG,Steer S,Hocking L,Reid DM,Harrison P,Wordsworth P,Abinum M,Becker M,Bell A,Craft A,Crawley E,David J,Griffin J,Hall A,Hall M,Herrick A,Hollingworth P,Holt L,Jones S,Pountain G,Ryder C,Southwood T,Stewart I,Venning H,Woo P,Wyatt S (2012) Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap Annals of the Rheumatic Diseases, 71(7), 1117 - 1121.
Gerss J,Roth J,Holzinger D,Ruperto N,Wittkowski H,Frosch M,Wulffraat N,Wedderburn L,Stanevicha V,Mihaylova D,Harjacek M,Len C,Toppino C,Masi M,Minden K,Saurenmann T,Uziel Y,Vesely R,Apaz MT,Kuester R-M,Elorduy MJR,Burgos-Vargas R,Ioseliani M,Magni-Manzoni S,Unsal E,Anton J,Balogh Z,Hagelberg S,Mazur-Zielinska H,Tauber T,Martini A,Foell D (2012) Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: A comparative study Annals of the Rheumatic Diseases, 71(12), 1991 - 1997.
Mcerlane F,Beresford MW,Baildam EM,Chieng SEA,Davidson JE,Foster HE,Gardner-Medwin J,Lunt M,Wedderburn LR,Thomson W,Hyrich KL (2012) Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis Annals of the Rheumatic Diseases.
Chinoy H,Li CK-C,Platt H,Fertig N,Varsani H,Gunawardena H,Betteridge Z,Oddis CV,Mchugh NJ,Wedderburn LR,Ollier WER,Cooper RG (2012) Genetic association study of NF-κB genes in UK caucasian adult and juvenile onset idiopathic inflammatory myopathy Rheumatology, 51(5), 794 - 799.
Lim D,Todd M,Kourtoglou N,Gerasimidis K,Gardner-Medwin J,Watson L,Tullus K,Pilkington C,Chesters C,Marks SD,Newland P,Jones C,Beresford MW,O'Neill P,Lee H,Tattersall R,McErlane F,Beresford M,Baildam E,Alice Chieng SE,Davidson J,Foster H,Gardner-Medwin J,Lunt M,Wedderburn LR,Thomson W,Hyrich KL,Kavirayani A,Thyagarajan MS,Ellis J,Helen Strike CN,Ramanan AV,Coda A,Davidson J,Fowlie P,Walsh J,Carline T,Santos D,Brimlow KW,Rangaraj S,Grant C,Little J,Helen Strike CN,Hinchcliffe A,Dick A,Ramanan A,Ekdawy D,Nagra G,Camina N,Edgerton J,Choi J,Lamb K,Hawley D,Rangaraj S,Cruikshank M,Sen E,Pain C,Leone V,Cruikshank M,Walsh J,on behalf of the SPARN Education Workgroup ,Tattersall R,Hawley D,Dunkley L,Lee H,McMahon AM,Bale P,Armon K,Amin T,Wood M,Davies R,Southwood TR,Kearsley-Fleet L,Hyrich KL,on behalf of the BSPAR Etanercept Register ,Kearsley-Fleet L,Baildam E,Beresford M,Davies R,Foster HE,Mowbray K,Southwood TR,Thomson W,Hyrich KL,Agarwal M,Kavirayani A,Ramanan AV,Ellis J,Smith E,Gray W,Taylor-Robinson D,Foster HE,Beresford MW,Morgan T,Watson L,Beresford MW,Gohar F,Watson L,Beresford MW,Artim-Esen B,Radziszewska A,Pericleous C,Rahman A,Giles I,Ioannou Y,Jashek D,Mosley E,Rangaraj S,Moraitis E,Arnold K,Pilkington C,Russell NJ,Roderick M,Ramanan A,Roderick M,Russell N,Ramanan AV,Smith NS,Wilson N,Gardner-Medwin J,Sen E,Chan M,Hardy E,Rapley T,Hensman P,Wraith JE,Foster H,Clarkson J,Gardner-Medwin J,Choudhery V,McVitty C,Davidson J,Hughes DH,Martin N,Warrier K,Sen E,Abinun M,Jandial S,O'Leary D,Staunton D,Lowry C,McSweeney N,Sen E,Abinun M,Friswell M,Foster H,Walsh A,Lowry C,Raja A (2012) BSPAR ANNUAL CONFERENCE ABSTRACTS * Oral presentations * O1. The impact of modern management on outcomes of JIA compared with healthy controls. Rheumatology (Oxford), 51(12), viii2 - viii14. 10.1093/rheumatology/kes277.
Cordingley L,Vracas T,Baildam E,Chieng A,Davidson J,Foster HE,Gardner-Medwin J,Wedderburn LR,Thomson W,Hyrich KL (2012) Juvenile-onset inflammatory arthritis: a study of adolescents' beliefs about underlying cause. Rheumatology (Oxford), 51(12), 2239 - 2245. 10.1093/rheumatology/kes216.
Omoyinmi E,Hamaoui R,Pesenacker A,Nistala K,Moncrieffe H,Ursu S,Wedderburn LR,Woo P (2012) Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis. Rheumatology (Oxford), 51(10), 1881 - 1886. 10.1093/rheumatology/kes162.
Wedderburn LR (2011) Regulatory T cells in arthritis: why do they fail?.
Southwood TR,Foster HE,Davidson JE,Hyrich KL,Cotter CB,Wedderburn LR,Hull RG,Venning HE,Rahman JK,Cummins CL (2011) Duration of etanercept treatment and reasons for discontinuation in a cohort of juvenile idiopathic arthritis patients Rheumatology, 50(1), 189 - 195.
Martin N,Krol P,Smith S,Murray K,Pilkington CA,Davidson JE,Wedderburn LR (2011) A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies Rheumatology, 50(1), 137 - 145.
Moncrieffe H,Nistala K,Eaton S,Wedderburn LR (2011) A novel defect: CD39+T cells are enriched in the inflamed joint but do not suppress CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 29(2), 376 - 376.
Krol P,Shah V,Eleftheriou D,Hong Y,Beresford M,Wedderburn L,Pilkington C,Brogan P (2011) Evidence for persistent endothelial injury and subclinical inflammation in juvenile dermatomyositis CLIN EXP RHEUMATOL, 29(2), 376 - 376.
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I (2011) Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells. PLoS One, 6(5), e20171. 10.1371/journal.pone.0020171.
Wedderburn LR,Pilkington CA,Beresford MW (2011) Connective Tissue Disorders in Children.
Wedderburn LR (2011) Juvenile Dermatomyositis.
Hinks A,Moncrieffe H,Martin P,Ursu S,Lal S,Kassoumeri L,Weiler T,Glass DN,Thompson SD,Wedderburn LR,Thomson W (2011) Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis Annals of the Rheumatic Diseases, 70(8), 1395 - 1400.
Ursu S,Moncrieffe H,Kassoumeri L,Wedderburn LR (2011) Effects of Methotrexate (MTX) treatment on cytokine profile and gene expression in Juvenile Idiopathic Arthritis (JIA) CLIN EXP RHEUMATOL, 29(2), 445 - 445.
Lal SD,McDonagh J,Baildam E,Wedderburn LR,Gardner-Medwin J,Foster HE,Chieng A,Davidson J,Adib N,Thomson W,Hyrich KL (2011) Agreement between proxy and adolescent assessment of disability, pain, and well-being in juvenile idiopathic arthritis Journal of Pediatrics, 158(2), 307 - 312.
Hunter PJ,Nistala K,Jina N,Eddaoudi A,Thomson W,Hubank M,Wedderburn LR (2010) Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression Arthritis and Rheumatism, 62(3), 896 - 907.
Nistala K,Adams S,Cambrook H,Ursu S,Olivito B,De Jager W,Evans JG,Cimaz R,Bajaj-Elliott M,Wedderburn LR (2010) Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14751 - 14756.
Moncrieffe H,Nistala K,Kamhieh Y,Evans J,Eddaoudi A,Eaton S,Wedderburn LR (2010) High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population Journal of Immunology, 185(1), 134 - 143.
Hinks A,Martin P,Flynn E,Eyre S,Packham J,Barton A,Baildam E,Brown L,Buckley J,Chieng A,Davidson J,Eltringham M,Foster H,Friswell M,Gardner-Medwin J,Gilbert P,Hyrich K,Jones J,Lal S,Lay M,Lydon C,Meijer A,Price V,Sim J,Todd M,Ward P,Wedderburn L,Bowes J,Orozco G,Thomson W,Worthington J,Martin S,Robinson JI,Morgan AW,Emery P,Wilson AG,Steer S,Hocking L,Reid DM,Harrison P,Wordsworth P,Abinum M,Becker M,Bell A,Craft A,Crawley E,David J,Gardener-Medwin J,Griffin J,Hall A,Hall M,Herrick A,Hollingworth P,Holt L,Jones S,Pountain G,Ryder C,Southwood T,Stewart I,Venning H,Woo P,Wyatt S (2010) Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis Annals of the Rheumatic Diseases, 69(12), 2169 - 2172.
Foell D,Wulffraat N,Wedderburn LR,Wittkowski H,Frosch M,Gerß J,Stanevicha V,Mihaylova D,Ferriani V,Tsakalidou FK,Foeldvari I,Cuttica R,Gonzalez B,Ravelli A,Khubchandani R,Oliveira S,Armbrust W,Garay S,Vojinovic J,Norambuena X,Gamir ML,García-Consuegra J,Lepore L,Susic G,Corona F,Dolezalova P,Pistorio A,Martini A,Ruperto N,Roth J (2010) Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission a randomized clinical trial JAMA - Journal of the American Medical Association, 303(13), 1266 - 1273.
Edwards LA,Nistala K,Mills DC,Stephenson HN,Zilbauer M,Wren BW,Dorrell N,Lindley KJ,Wedderburn LR,Bajaj-Elliott M (2010) Delineation of the innate and adaptive T-cell immune outcome in the human host in response to campylobacter jejuniinfection PLoS ONE, 5(11).
Moncrieffe H,Hinks A,Ursu S,Kassoumeri L,Etheridge A,Hubank M,Martin P,Weiler T,Glass DN,Thompson SD,Thomson W,Wedderburn LR (2010) Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: Correlation between gene expression and genotype Pharmacogenetics and Genomics, 20(11), 665 - 676.
Liu C,Walter TS,Huang P,Zhang S,Zhu X,Wu Y,Wedderburn LR,Tang P,Owens RJ,Stuart DI,Ren J,Gao B (2010) Structural and functional insights of RANKL-RANK interaction and signaling Journal of Immunology, 184(12), 6910 - 6919.
Hunter PJ,Wedderburn LR (2009) Pediatric rheumatic disease: can molecular profiling predict the future in JIA? Nat Rev Rheumatol, 5(11), 593 - 594. 10.1038/nrrheum.2009.215.
Nistala K,Wedderburn LR (2009) Th17 and regulatory T cells: Rebalancing pro- and anti-inflammatory forces in autoimmune arthritis Rheumatology, 48(6), 602 - 606.
Nistala K,Woo P,Wedderburn LR (2009) Juvenile idiopathic arthritis, 2, 1657 - 1675.
Moncrieffe H,Mato H,Wedderburn LR (2009) The 15th Paediatric Rheumatology European Society (PReS) Congress. International Journal of Advances in Rheumatology, 6(4), 151 - 153.
Salomonsson S,Grundtman C,Zhang S-J,Lanner JT,Li C,Katz A,Wedderburn LR,Nagaraju K,Lundberg IE,Westerblad H (2009) Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle Muscle and Nerve, 39(5), 674 - 682.
Mulligan K,Etheridge A,Kassoumeri L,Wedderburn LR,Newman S (2009) Do mothers and fathers hold similar views about their child's arthritis? Arthritis Care and Research, 61(12), 1712 - 1718.
Abinun M,Flood TJ,Cant AJ,Veys P,Gennery AR,Foster HE,Friswell M,Baildam E,Davidson J,Southwood TR,Livermore P,Wedderburn LR (2009) Autologous T cell depleted haematopoietic stem cell transplantation in children with severe juvenile idiopathic arthritis in the UK (2000-2007) Molecular Immunology, 47(1), 46 - 51.
Hinks A,Ke X,Barton A,Eyre S,Bowes J,Worthington J,Wilson AG,Morgan A,Emery P,Steer S,Hocking L,Reid DM,Wordsworth P,Harrison P,Symmons D,Abinum M,Becker M,Bell A,Craft A,Crawley E,David J,Foster H,Gardener-Medwin J,Griffin J,Hall A,Hall M,Herrick A,Hollingworth P,Holt L,Jones S,Pountain G,Ryder C,Southwood T,Stewart I,Venning H,Wedderburn L,Woo P,Wyatt S,Conaghan P,Quinn M,Keenan A-M,Hensor E,Kitcheman J,Gough A,Green M,Reece R,Hordon L,Helliwell P,Melsom R,Doherty S,Adebajo A,Harvey A,Jarrett S,Huson G,Isdale A,Martin M,Karim Z,McGonagle D,Pease C,Cox S,Bejarano V,Nam J,Brown C,Thomas C,Pickles D,Hammond A,Neville B,Fairclough A,Nunns C,Gill A,Green J,Rhys-Evans B,Padwell B,Madden J,Taylor L,Smith S,King H,Firth J,Heard J,Sigsworth L,Corscadden D,Henshaw K,Rashid L-H,Martin SG,Robinson JI,Thompson SD,Langefeld CD,Glass DN,Thomson W (2009) Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis Arthritis and Rheumatism, 60(1), 251 - 257.
Gunawardena H,Wedderburn LR,Chinoy H,Betteridge ZE,North J,Ollier WER,Cooper RG,Oddis CV,Ramanan AV,Davidson JE,McHugh NJ (2009) Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis Arthritis and Rheumatism, 60(6), 1807 - 1814.

Biography