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Prof Tom Warner

  • Telephone:

    0207 679 4246

  • Extension:

    #6 292 x34965

  • Fax:

    0207 278 4993

  • Email:

    t.warner@ucl.ac.uk

  • Address:

    U3/99 Reta Lila Weston Institute, UCL Institute of Neurology,
    1 Wakefield Street,
    London,
    WC1N 1PJ

  • Appointments:

    Chair of Clinical Neurology & Director of the Reta Lila Weston Institute, Molecular Neuroscience, Institute of Neurology

Research Summary

Dystonia:
Clinical: Epidemiology of dystonia and clinical phenotypes
Molecular genetic: identifying families with primary dystonia for gene mapping and study of mutations in myoclonus dystonia. Study of susceptibilty loci in primary focal dystonia.
Cell biology: Study of transgenic cell models of DYT1 dystonia and identification of novelprotien partners and pathogenic mechanisms e.g.identifying defects in synaptic vesicle recycling and stability of synaptic proteins.
Producing induced pluripotential cell lines for primary (DYT1) dystonia and rapid-onset dystonia parkinsonism for study of mechanisms in differentiated neuronal lines.
Hereditary Spastic paraplegia:
Clinical and genetic studies of HSP mapping and cloning genes.
Pathogenetic studies particularly of SPG4 and 5. Study of microtubule bundling and severing and axonal transport in SPG 4 HSP and cholesterol metabolism in SPG5 HSP. Study of novel transgenic model of HSP.
Huntington's disease:
UK Coordinator of PREDICT-HD multinational study to identify presymptomatic biomarkers of disease. PI for neuroendocrine study of HD in presymptomatic and manifesting patients to identify biomarkers and factors that produce the hypermetabolic state in HD.

Research Activities

  • Clinical, genetic and cell biology studies of hereditary movement disorders: dystonia, Huntington’s disease, Hereditary spastic paraplegia
  • Dopaminergic neuronal differentiation of human adipose stem cells
  • Gene therapy for neurological disorders
  • Inducible pluripotent stem cells from a family with rapid-onset dystonia-parkinsonism

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Casper C,Kalliolia E,Warner TT (2013) Recent Advances in the Molecular Pathogenesis of Dystonia-Plus Syndromes and Heredodegenerative Dystonias CURRENT NEUROPHARMACOLOGY, 11(1), 30 - 40.
  2. Peall KJ,Smith DJ,Kurian MA,Wardle M,Waite AJ,Hedderly T,Lin JP,Smith M,Whone A,Pall H,White C,Lux A,Jardine P,Bajaj N,Lynch B,Kirov G,O'Riordan S,Samuel M,Lynch T,King MD,Chinnery PF,Warner TT,Blake DJ,Owen MJ,Morris HR (2013) SGCE mutations cause psychiatric disorders: clinical and genetic characterization. Brain, 136(Pt 1), 294 - 303. 10.1093/brain/aws308.
  3. Peall KJ,Smith DJ,Kurian MA,Wardle M,Waite AJ,Hedderly T,Lin J-P,Smith M,Whone A,Pall H,White C,Lux A,Jardine P,Bajaj N,Lynch B,Kirov G,O'Riordan S,Samuel M,Lynch T,King MD,Chinnery PF,Warner TT,Blake DJ,Owen MJ,Morris HR (2013) SGCE mutations cause psychiatric disorders: Clinical and genetic characterization Brain, 136(1), 294 - 303.
  4. Gardiner AR,Bhatia KP,Stamelou M,Dale RC,Kurian MA,Schneider SA,Wali GM,Counihan T,Schapira AH,Spacey SD,Valente E-M,Silveira-Moriyama L,Teive HAG,Raskin S,Sander JW,Lees A,Warner T,Kullmann DM,Wood NW,Hanna M,Houlden H (2012) PRRT2 gene mutations From paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine NEUROLOGY, 79(21), 2115 - 2121.
  5. Peall K,Waite AJ,Kurian MA,Hedderly T,Smith M,Lin JP,Warner TT,Pall H,Chinnery P,Whone A,Owen MJ,Blake DJ,Morris HR (2012) MYOCLONUS DYSTONIA: A CLINICAL AND GENETIC DESCRIPTION JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83(3). 10.1136/jnnp-2011-301993.29.
  6. Gardiner AR,Bhatia KP,Stamelou M,Dale RC,Kurian MA,Schneider SA,Wali GM,Counihan T,Schapira AH,Spacey SD,Valente EM,Silveira-Moriyama L,Teive HA,Raskin S,Sander JW,Lees A,Warner T,Kullmann DM,Wood NW,Hanna M,Houlden H (2012) PRRT2 gene mutations: from paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology, 79(21), 2115 - 2121. 10.1212/WNL.0b013e3182752c5a.
  7. Hobart JC,Cano SJ,Warner TT,Thompson AJ (2012) What sample sizes for reliability and validity studies in neurology? Journal of Neurology, 1 - 14.
  8. Peall K,Waite A,Kurian M,Wardle M,Hedderly T,Lin JP,Smith M,Pall H,King M,Lynch T,White C,Chinnery P,Warner T,Blake D,Owen M,Morris H (2012) Myoclonus dystonia syndrome: SGCE mutations and psychiatric disease JOURNAL OF NEUROLOGY, 259, S30 - S30.
  9. Clark CN,Weber YW,Lerche H,Warner TT (2012) Paroxysmal exercise-induced dyskinesia of the hands. Mov Disord, 27(12), 1579 - 1580. 10.1002/mds.25200.
  10. Hobart JC,Cano SJ,Warner TT,Thompson AJ (2012) What sample sizes for reliability and validity studies in neurology? JOURNAL OF NEUROLOGY, 259(12), 2681 - 2694. 10.1007/s00415-012-6570-y.
  11. Vaccarino AL,Anderson K,Borowsky B,Duff K,Giuliano J,Guttman M,Ho AK,Orth M,Paulsen JS,Sills T,van Kammen DP,Evs KR,Investigators PREDICT-HD,Investigators REGISTRY (2011) An Item Response Analysis of the Motor and Behavioral Subscales of the Unified Huntington's Disease Rating Scale in Huntington Disease Gene Expansion Carriers MOVEMENT DISORDERS, 26(5), 877 - 884. 10.1002/mds.23574.
  12. Nopoulos PC,Aylward EH,Ross CA,Mills JA,Langbehn DR,Johnson HJ,Magnotta VA,Pierson RK,Beglinger LJ,Nance MA,Barker RA,Paulsen JS,Coordinat PREDICT-HDI (2011) Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment BRAIN, 134, 137 - 142. 10.1093/brain/awq280.
  13. Phukan J,Albanese A,Gasser T,Warner T (2011) Primary dystonia and dystonia-plus syndromes: clinical characteristics, diagnosis, and pathogenesis. Lancet Neurol, 10(12), 1074 - 1085. 10.1016/S1474-4422(11)70232-0.
  14. Casper CJ,Warner TT,Taanman JW,Nathwani AC (2011) Generation of iPS-derived dopaminergic neurons as an in-vitro model of Rapid-Onset Dystonia Parkinsonism HUMAN GENE THERAPY, 22(10), A42 - A43.
  15. Aylward EH,Nopoulos PC,Ross CA,Langbehn DR,Pierson RK,Mills JA,Johnson HJ,Magnotta VA,Juhl AR,Paulsen JS,Coordina PREDICT-HDI (2011) Longitudinal change in regional brain volumes in prodromal Huntington disease JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 82(4), 405 - 410. 10.1136/jnnp.2010.208264.
  16. Carlozzi NE,Stout JC,Mills JA,Duff K,Beglinger LJ,Aylward EH,Whitlock KB,Solomon AC,Queller S,Langbehn DR,Johnson SA,Paulsen JS,Huntingto PREDICT-HDI (2011) Estimating Premorbid IQ in the Prodromal Phase of a Neurodegenerative Disease CLINICAL NEUROPSYCHOLOGIST, 25(5), 757 - 777. 10.1080/13854046.2011.577811.
  17. Cleeter M,Houlden H,Simons P,Al-Shawi R,Stevanin G,Durr A,Hsuan J,Warner TT (2011) Screening for mutations in the phosphatidylinositol 4-kinase 2-alpha gene in autosomal recessive hereditary spastic paraplegia Amyotrophic Lateral Sclerosis, 12, 148 - 149.
  18. O'Rourke JJF,Beglinger LJ,Smith MM,Mills J,Moser DJ,Rowe KC,Langbehn DR,Duff K,Stout JC,Harrington DL,Carlozzi N,Paulsen JS,Investigators PREDICT-HD (2011) The Trail Making Test in prodromal Huntington disease: Contributions of disease progression to test performance JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 33(5), 567 - 579. 10.1080/13803395.2010.541228.
  19. Peall KJ,Waite AJ,Kurian MA,Hedderly T,Smith M,Lin J-P,King MD,Warner TT,Pall H,Chinnery P,Whone A,Mantripragada KK,Williams NM,Owen MJ,Blake DJ,Morris HR (2011) Clinical and genetic spectrum of myoclonus dystonia syndrome MOVEMENT DISORDERS, 26, S315 - S316.
  20. TT PJWCDKBRNMBLMDWJSSLDVKDTPHIOTHSGIW (2010) Challenges assessing clinical endpoints in early Huntington disease. Mov Disord.
  21. Dressler D,Warner T (2010) Dystonia Europe: Hamburg 2008 FOREWORD EUROPEAN JOURNAL OF NEUROLOGY, 17, V - V. 10.1111/j.1468-1331.2010.03062.x.
  22. TT DKPJMJBLMDSMLDSJQSHDP-HIACOTHSGIW (2010) Mild cognitive impairment in prediagnosed Huntington disease. Neurology, 75, 500 - 507.
  23. Warner TT,Granata A,Schiavo G (2010) TorsinA and DYT1 dystonia: a synaptopathy? Biochem Soc Trans, 38(2), 452 - 456. 10.1042/BST0380452.
  24. Langbehn DR,Hayden MR,Paulsen JS,Huntingto PREDICT-HDI (2010) CAG-Repeat Length and the Age of Onset in Huntington Disease (HD): A Review and Validation Study of Statistical Approaches AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 153B(2), 397 - 408. 10.1002/ajmg.b.30992.
  25. Rowe KC,Paulsen JS,Langbehn DR,Duff K,Beglinger LJ,Wang C,O'Rourke JJF,Stout JC,Moser DJ,Huntingto PREDICT-HDI (2010) Self-Paced Timing Detects and Tracks Change in Prodromal Huntington Disease NEUROPSYCHOLOGY, 24(4), 435 - 442. 10.1037/a0018905.
  26. Dressler D,Warner T (2010) Dystonia Europe: Hamburg 2008 European Journal of Neurology, 17(SUPPL. 1).
  27. TT DKPJBLLDWCSJRCAECNQSP-HIOTHSGIW (2010) "Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness. J Neuropsychiatry Clin Neurosci, 22, 196 - 207.
  28. TT PJNPAERCJHMVJAPRMJLDNMP-HIACOTHSGIW (2010) Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull, 82, 201 - 207.
  29. Granata A WTT (2010) The role of TorsinA in dystonia Eur J Neurol, 17(Suppl.1), 81 - 87.
  30. Granata A,Warner TT (2010) The role of torsinA in dystonia EUROPEAN JOURNAL OF NEUROLOGY, 17, 81 - 87. 10.1111/j.1468-1331.2010.03057.x.
  31. Soneson C,Fontes M,Zhou Y,Denisov V,Paulsen JS,Kirik D,Petersen A,The Huntington Study Group PREDICT-HD investigators (2010) Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis Neurobiology of Disease, 40(3), 531 - 543. 10.1016/j.nbd.2010.07.013.
  32. Nopoulos PC,Aylward EH,Ross CA,Johnson HJ,Magnotta V,Juhl A,Pierson RK,Mills J,Langbehn DR,Paulsen JS,PREDICT-HD Investigators Coordinators of the Huntington Study Group (HSG) (2010) Cerebral cortex structure in prodromal Huntington disease Neurobiology of Disease, 40(3), 544 - 554. 10.1016/j.nbd.2010.07.014.
  33. Biglan KM,Ross CA,Langbehn DR,Aylward EH,Stout JC,Queller S,Carlozzi NE,Duff K,Beglinger LJ,Paulsen JS,Group HS (2009) Motor Abnormalities in Premanifest Persons with Huntington's Disease: The PREDICT-HD Study MOVEMENT DISORDERS, 24(12), 1763 - 1772. 10.1002/mds.22601.
  34. Warner TT (2009) Motor Neuron Diseases, 150 - 174.
  35. Warner TT (2009) DNA, Genes and mutations, 1 - 10.
  36. Warner TT (2009) Dementia, 24 - 37.
  37. Kloppel S,Chu C,Tan G,Draganski B,Johnson H,Paulsen JS,Kienzle W,Tabrizi SJ,Ashburner J,Frackowiak RSJ,Predict-HD IOTHSG (2009) Automatic detection of pre-clinical neurodegeneration: pre-symptomatic Huntington’s disease Neurology, 72(5), 426 - 431. 10.1212/01.wnl.0000341768.28646.b6.
  38. Smith BN,Bevan S,Vance C,Renwick P,Wilkinson P,Proukakis C,Squitieri F,Berardelli A,Warner TT,Reid E,Shaw CE (2009) Four novel SPG3A/atlastin mutations identified in autosomal dominant hereditary spastic paraplegia kindreds with intra-familial variability in age of onset and complex phenotype Clinical Genetics, 75(5), 485 - 489. 10.1111/j.1399-0004.2009.01184.x.
  39. Simons JP,Al-Shawi R,Minogue S,Waugh MG,Wiedemann C,Evangelou S,Loesch S,Sihra TS,King R,Warner TT,Hsuan JJ (2009) Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons Proceedings of the National Academy of Sciences of the United States of America, 106(28), 11535 - 11539. 10.1073/pnas.0903011106.
  40. Warner TT (2009) The genetics and pathogenesis of dystonia, 457 - 473.
  41. (2009) Practical Guide to Neurogenetics.
  42. Warner TT (2009) Movement Disorders, 102 - 136.
  43. Warner TT (2009) Cerebrovascular Disease, 137 - 149.
  44. Taanman JW,Daras M,Albrecht J,Davie CA,Mallam EA,Muddle JR,Weatherall M,Warner TT,Schapira AH,Ginsberg L (2009) Characterization of a novel TYMP splice site mutation associated with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) Neuromuscul.Disord., 19(2), 151 - 154.
  45. Granata A,Schiavo G,Warner TT (2009) TorsinA and dystonia: from nuclear envelope to synapse. Journal of Neurochemistry, 109(6), 1596 - 1609. 10.1111/j.1471-4159.2009.06095.x.
  46. Granata A,Watson R,Collinson LM,Schiavo G,Warner TT (2008) The dystonia-associated protein torsinA modulates synaptic vesicle recycling. Journal of Biological Chemistry, 283(12), 7568 - 7579. 10.1074/jbc.M704097200.
  47. Salinas S,Proukakis C,Crosby A,Warner TT (2008) Hereditary spastic paraplegia: Clinical features and pathogenetic mechanisms. Lancet Neurology, 7(12), 1127 - 1138. 10.1016/S1474-4422(08)70258-8.
  48. Cano SJ,Warner TT,Thompson AJ,Bhatia KP,Fitzpatrick R,Hobart JC (2008) The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria? Health and Quality of Life Outcomes, 6, 58. 10.1186/1477-7525-6-58.
  49. Tsaousidou MK,Ouahchi K,Warner TT,Yang Y,Simpson MA,Laing NG,Wilkinson PA,Madrid RE,Patel H,Hentati F,Patton MA,Hentati A,Lamont PJ,Siddique T,Crosby AH (2008) Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. American Journal of Human Genetics, 82(2), 510 - 515. 10.1016/j.ajhg.2007.10.001.
  50. Paulsen JS,Langbehn DR,Stout JC,Aylward E,Ross CA,Nance M,Guttman M,Johnson S,MacDonald M,Beglinger LJ,Duff K,Kayson E,Biglan K,Shoulson I,Oakes D,Hayden M,Predict-HD IACOTHSG (2008) Detection of Huntington's disease decades before diagnosis: the Predict-HD study Journal of Neurology, Neurosurgery and Psychiatry, 79(8), 874 - 880. 10.1136/jnnp.2007.128728.

Qualifications

  • : Bachelor of Medicine, Bachelor of Surgery, To be updated
  • 1987: Bachelor of Arts (Honours), University of Oxford

Keywords

  • Axon degeneration
  • Axonal transport
  • Basal ganglia
  • Cell culture
  • Clinical, genetic and cell biology studies of hereditary movement disorders: dystonia, Huntington's disease, Hereditary spastic paraplegia
  • Confocal microscopy
  • Dopamine
  • Dystonia
  • Enzyme assays
  • Epidemiology
  • Exocytosis
  • Friederich's ataxia
  • Genetic manipulation (including knockout/knockin)
  • Genetic screens
  • Genetics
  • Genomic analyses
  • Huntington's disease
  • Light microscopic techniques
  • Linkage, mapping and positional cloning
  • MiRNA analysis
  • Microarrays
  • Motor control
  • Movement disorders
  • Myoclonus
  • Neurodegeneration
  • Neurodegenerative diseases
  • Parkinson's disease
  • Plasticity
  • Protein aggregation
  • Protein misfolding
  • Protein transport/localisation
  • Recombinant protein expression
  • Spinocerebellar atrophy
  • Transgenic mice
  • Tremor
  • Viral vectors
  • cell biology
  • synaptic function