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Prof Tamas Revesz

Summary


Research

As an academic neuropathologist my research has mainly focused on understanding pathomechanism of neurodegenerative diseases. The major topics pursued in the past 12 years include:

1. Cerebral amyloid formation and neurodegeneration

  • Papers in Nature, Proc Natl Acad Sci, Brain, Ann Neurol, Am J Pathol, J Biol Chem, J Neuropathol Exp Neurol, Acta Neuropathol, Neuropathol Appl Neurobiol
2. Frontotemporal lobar degeneration

  • Papers in Brain, Acta Neuropathol, Neurology, Neuropathol Appl Neurobiol
3. Parkinson’s disease: disease spread, factors influencing disease manifestation

  • Papers in Nat Med, Nat Rev Neurosci, Lancet, Brain, Ann Neurol, Acta Neuropathol
4. Clinical, genetic, biochemical and pathological subgroups in progressive supranuclear palsy

  • Papers in Brain, Nat Genetics, Ann Neurol, Mov Disord, FEBS Lett
ResearcherID: http://www.researcherid.com/rid/A-8732-2010 

Research Summary

Research at the Queen Square Brain Bank for Neurological Disorders includes studies on Parkinson's disease. In one such collaborative study, carried out by several groups of the Department of Molecular Neuroscience, UCL Institute of Neurology, we characterized the expression of PINK1 protein in normal human and sporadic Parkinson's disease brains in addition to Parkinson's cases with heterozygous PINK1 mutations. With brain fractionation studies we confirmed that PINK1 is localized to the mitochondrial membranes. In addition, we showed that PINK1 is present in a proportion of Lewy bodies in cases of sporadic Parkinson's disease and Parkinson's disease associated with heterozygous mutations in the PINK1 gene. Our studies provided for the first time in vivo morphological and biochemical evidence to support a mitochondrial localization of PINK1 and support the significance of mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Alpha synuclein is studied in relation to sporadic Parkinson's disease. By studying Parkinson cases, which were treated in life with transplantation of human embryonal mesencephalic dopaminergic cells into the patients striatum, we were able to show that the disease spreads from the host to graft.

The large, well documented case collection of the QSBB has also permitted detailed clinicopathological studies of different movement disorders, such as multiple system atrophy, progressive supranuclear palsy and frontotemporal dementias. In studies on progressive supranuclear palsy we were able to demonstrate an association between cerebral accumulation of hyperphosphorylated tau and clinical phenotypes. Examples of rare diseases in the collection have led to the identification of their genetic abnormalities and/or enabled us to perform detailed description and study of entities such as the familial British and familial Danish dementias and neurofilament inclusion body disease.

Research Activities

  • A systematic investigation into the pathogenesis and course of Parkinson's syndrome
  • Investigating the molecular basis of frontotemporal dementia
  • Neuropathology of protein folding disorders
  • Parkinsons disease and related Movement Disorders

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Doherty KM,Silveira-Moriyama L,Parkkinen L,Healy DG,Farrell M,Mencacci NE,Ahmed Z,Brett FM,Hardy J,Quinn N,Counihan TJ,Lynch T,Fox ZV,Revesz T,Lees AJ,Holton JL (2013) Parkin disease - a clinicopathological entity? NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 11 - 12.
  2. Brelstaff J,Mamais A,Lashley T,Holton JL,Revesz T,Bandopadhyay R (2013) The aggregate proteins of FTLD-FUS are re-localised to stress granules upon oxidative stress NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 46 - 47.
  3. Lashley T,Rohrer JD,Mahoney CJ,Polke JM,Ryan NS,Isaacs A,Mead S,Warren JD,Revesz T (2013) Clinical and pathological features of frontotemporal dementia linked to C9ORF72 homozygosity NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 30 - 31.
  4. Ling H,Petrovic IN,Lang AE,Lees AJ (2013) Reply to letter: Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch. Mov Disord, 28(3), 408. 10.1002/mds.25288.
  5. Selikhova M,Kempster PA,Revesz T,Holton JL,Lees AJ (2013) Neuropathological findings in benign tremulous Parkinsonism Movement Disorders, 28(2), 145 - 152.
  6. Saul A,Lashley T,Revesz T,Holton J,Ghiso JA,Coomaraswamy J,Wirths O (2013) Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias Neurobiology of Aging, 34(5), 1416 - 1425.
  7. Kiely AP,Asi YT,Kara E,Limousin P,Ling H,Lewis P,Proukakis C,Quinn N,Lees AJ,Hardy J,Revesz T,Houlden H,Holton JL (2013) α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathologica, 1 - 17.
  8. Fawcett K,Mehrabian M,Liu YT,Hamed S,Elahi E,Revesz T,Koutsis G,Herscheson J,Schottlaender L,Wardle M,Morrison PJ,Morris HR,Giunti P,Wood N,Houlden H (2013) Erratum to: The frequency of spinocerebellar ataxia type 23 in a UK population. J Neurol, 260(3), 860. 10.1007/s00415-012-6791-0.
  9. Ling H,Kara E,Bandopadhyay R,Hardy J,Holton J,Xiromerisiou G,Lees A,Houlden H,Revesz T (2013) TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT Neurobiology of Aging.
  10. Massey LA,Jäger HR,Paviour DC,O'Sullivan SS,Ling H,Williams DR,Kallis C,Holton J,Revesz T,Burn DJ,Yousry T,Lees AJ,Fox NC,Micallef C (2013) The midbrain to pons ratio: A simple and specific MRI sign of progressive supranuclear palsy. Neurology, 80(20), 1856 - 1861. 10.1212/WNL.0b013e318292a2d2.
  11. Pressey SN,Murray CE,Heywood W,Gentleman SM,Mills K,Holton JL,Gandhi S,Revesz T (2013) Uncovering early markers of Parkinson's disease pathological progression using proteomics NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 24 - 24.
  12. Rajan S,Bandopadhyay R,Kingsbury A,Ayling H,Sterlacci W,Poewe W,Maier H,Ezquerro M-TH,Lees AJ,Revesz T,Silveira-Moriyama L (2013) Using the anterior olfactory nucleus to study Lewy pathology in olfactory structures NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 49 - 50.
  13. Asi YT,Ling H,Ahmed Z,Lees AJ,Revesz T,Holton JL (2013) Cognitive impairment in multiple system atrophy: a clinico-pathological study NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 36 - 36.
  14. Compta Y,Revesz T,Lees AJ (2013) The more cortical amyloid-β, the more postural instability in parkinson's disease: More grist to the mill for a link between walking, falling, and remembering? Movement Disorders, 28(3), 263 - 264.
  15. Ling H,de Silva R,Massey LA,Courtney R,Hondhamuni G,Bajaj N,Lowe J,Holton JL,Lees A,Revesz T (2013) Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant. Neuropathol Appl Neurobiol. 10.1111/nan.12037.
  16. Selikhova M,Kempster PA,Revesz T,Holton JL,Lees AJ (2013) Neuropathological findings in benign tremulous parkinsonism. Mov Disord, 28(2), 145 - 152. 10.1002/mds.25220.
  17. Petrovic IN,Martin-Bastida A,Massey L,Ling H,O'Sullivan SS,Williams DR,Holton JL,Revesz T,Ironside JW,Lees AJ,Silveira-Moriyama L (2013) MM2 subtype of sporadic Creutzfeldt-Jakob disease may underlie the clinical presentation of progressive supranuclear palsy. J Neurol, 260(4), 1031 - 1036. 10.1007/s00415-012-6752-7.
  18. Fawcett K,Mehrabian M,Liu Y-T,Hamed S,Elahi E,Revesz T,Koutsis G,Herscheson J,Schottlaender L,Wardle M,Morrison PJ,Morris HR,Giunti P,Wood N,Houlden H (2013) The frequency of spinocerebellar ataxia type 23 in a UK population Journal of Neurology, 260(3), 856 - 859.
  19. Holmans P,Moskvina V,Jones L,Sharma M,International Parkinson's Disease Genomics Consortium ,Vedernikov A,Buchel F,Sadd M,Bras JM,Bettella F,Nicolaou N,Simón-Sánchez J,Mittag F,Gibbs JR,Schulte C,Durr A,Guerreiro R,Hernandez D,Brice A,Stefánsson H,Majamaa K,Gasser T,Heutink P,Wood NW,Martinez M,Singleton AB,Nalls MA,Hardy J,Morris HR,Williams NM (2013) A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Hum Mol Genet, 22(5), 1039 - 1049. 10.1093/hmg/dds492.
  20. Petrovic IN,Martin-Bastida A,Massey L,Ling H,O'Sullivan SS,Williams DR,Holton JL,Revesz T,Ironside JW,Lees AJ,Silveira-Moriyama L (2013) MM2 subtype of sporadic Creutzfeldt-Jakob disease may underlie the clinical presentation of progressive supranuclear palsy Journal of Neurology, 260(4), 1031 - 1036.
  21. Ahmed Z,Asi YT,Lees AJ,Revesz T,Holton JL (2013) Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and parkinson's disease Brain Pathology, 23(3), 263 - 273.
  22. Kiely AP,Asi YT,Kara E,Limousin P,Ling H,Lewis P,Proukakis C,Quinn N,Lees AJ,Hardy J,Revesz T,Houlden H,Holton JL (2013) Synucleinopathy with a G51D a-synuclein mutation: a neuropathological and genetic study NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 39, 39 - 40.
  23. Louro Guerreiro RJ,Woltas AMS,Bras J,Carrasquillo M,Ekaterina R,Majounie E,Cruchaga C,Sassi C,Kauwe JSK,Younkin S,Hazrati L,Collinge J,Pocock J,Lashley T,Williams J,Lambert JC,Amouyel P,Goate A,Rademakers R,Morgan K,Powell J,St. George-Hyslop P,Singleton A,Hardy J (2012) TREM2 Variants in Alzheimer's Disease New England Journal of Medicine. 10.1056/NEJMoa211851.
  24. McNaughton D,Knight W,Guerreiro R,Ryan N,Lowe J,Poulter M,Nicholl DJ,Hardy J,Revesz T,Lowe J,Rossor M,Collinge J,Mead S (2012) Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiol Aging, 33(2), 426.e13 - 426.e21. 10.1016/j.neurobiolaging.2010.10.010.
  25. Ling H,de Silva R,Massey L,Bajaj N,Lowe J,Holton J,Lees A,Revesz T (2012) Clinicopathological correlation of progressive supranuclear palsy presenting with corticobasal syndrome EUROPEAN JOURNAL OF NEUROLOGY, 19, 290 - 290.
  26. Keller MF,Saad M,Bras J,Bettella F,Nicolaou N,Simón-Sánchez J,Mittag F,Büchel F,Sharma M,Gibbs JR,Schulte C,Moskvina V,Durr A,Holmans P,Kilarski LL,Guerreiro R,Hernandez DG,Brice A,Ylikotila P,Stefánsson H,Majamaa K,Morris HR,Williams N,Gasser T,Heutink P,Wood NW,Hardy J,Martinez M,Singleton AB,Nalls MA,International Parkinson's Disease Genomics Consortium (IPDGC) ,Wellcome Trust Case Control Consortium 2 (WTCCC2) (2012) Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet, 21(22), 4996 - 5009. 10.1093/hmg/dds335.
  27. Paudel R,Hardy J,Revesz T,Holton JL,Houlden H (2012) Review: Genetics and neuropathology of primary pure dystonia Neuropathology and Applied Neurobiology, 38(6), 520 - 534.
  28. Paudel R,Hardy J,Revesz T,Holton JL,Houlden H (2012) Review: genetics and neuropathology of primary pure dystonia. Neuropathol Appl Neurobiol, 38(6), 520 - 534. 10.1111/j.1365-2990.2012.01298.x.
  29. Hardy J,Revesz T (2012) The spread of neurodegenerative disease. N Engl J Med, 366(22), 2126 - 2128. 10.1056/NEJMcibr1202401.
  30. Kara E,Ling H,Pittman AM,Shaw K,de Silva R,Simone R,Holton JL,Warren JD,Rohrer JD,Xiromerisiou G,Lees A,Hardy J,Houlden H,Revesz T (2012) The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features Neurobiology of Aging.
  31. Massey LA,Micallef C,Paviour DC,O'Sullivan SS,Ling H,Williams DR,Kallis C,Holton JL,Revesz T,Burn DJ,Yousry T,Lees AJ,Fox NC,Jäger HR (2012) Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy Movement Disorders.
  32. Mahoney CJ,Beck J,Rohrer JD,Lashley T,Mok K,Shakespeare T,Yeatman T,Warrington EK,Schott JM,Fox NC,Rossor MN,Hardy J,Collinge J,Revesz T,Mead S,Warren JD (2012) Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: Clinical, neuroanatomical and neuropathological features Brain, 135(3), 736 - 750.
  33. Li A,Paudel R,Johnson R,Courtney R,Lees AJ,Holton JL,Hardy J,Revesz T,Houlden H (2012) Pantothenate kinase-associated neurodegeneration is not a synucleinopathy. Neuropathol Appl Neurobiol. 10.1111/j.1365-2990.2012.01269.x.
  34. Zadeh G,Salehi F,An S,Uff C,Camp S,Revesz T,Holton J,Thom M,Mcevoy AW,Grieve J,Kitchen N,Brandner S (2012) Diagnostic implications of histological analysis of neurosurgical aspirate in addition to routine resections Neuropathology, 32(1), 44 - 50.
  35. McNaughton D,Knight W,Guerreiro R,Ryan N,Lowe J,Poulter M,Nicholl DJ,Hardy J,Revesz T,Rossor M,Collinge J,Mead S (2012) Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series Neurobiology of Aging, 33(2), 426.e13 - 426.e21.
  36. Massey LA,Miranda MA,Zrinzo L,Al-Helli O,Parkes HG,Thornton JS,So PW,White MJ,Mancini L,Strand C,Holton JL,Hariz MI,Lees AJ,Revesz T,Yousry TA (2012) High resolution MR anatomy of the subthalamic nucleus: imaging at 9.4 T with histological validation. Neuroimage, 59(3), 2035 - 2044. 10.1016/j.neuroimage.2011.10.016.
  37. Paisán-Ruiz C,Li A,Schneider SA,Holton JL,Johnson R,Kidd D,Chataway J,Bhatia KP,Lees AJ,Hardy J,Revesz T,Houlden H (2012) Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiol Aging, 33(4), 814 - 823. 10.1016/j.neurobiolaging.2010.05.009.
  38. Massey LA,Micallef C,Paviour DC,O'Sullivan SS,Ling H,Williams DR,Kallis C,Holton JL,Revesz T,Burn DJ,Yousry T,Lees AJ,Fox NC,Jager HR (2012) Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy. Movement Disorders.
  39. Revesz T (2012) Update on tauopathies: pathological features EUROPEAN JOURNAL OF NEUROLOGY, 19, 822 - 822.
  40. Ahmed Z,Asi YT,Lees AJ,Revesz T,Holton JL (2012) Identification and Quantification of Oligodendrocyte Precursor Cells in Multiple System Atrophy, Progressive Supranuclear Palsy and Parkinson's Disease Brain Pathology.
  41. Fawcett K,Mehrabian M,Liu Y-T,Hamed S,Elahi E,Revesz T,Koutsis G,Herscheson J,Schottlaender L,Wardle M,Morrison PJ,Morris HR,Giunti P,Wood N,Houlden H (2012) The frequency of spinocerebellar ataxia type 23 in a UK population Journal of Neurology, 1 - 4.
  42. Kara E,Ling H,Pittman AM,Shaw K,de Silva R,Simone R,Holton JL,Warren JD,Rohrer JD,Xiromerisiou G,Lees A,Hardy J,Houlden H,Revesz T (2012) The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features Neurobiology of Aging, 33(9), 2231e7 - 2231e14.
  43. Ahmed Z,Revesz T,Holton JL (2012) Neuropathology and pathophysiology of multiple system atrophy Response NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 38(4), 381 - 381. 10.1111/j.1365-2990.2012.01266.x.
  44. Ahmed Z,Revesz T,Holton JL (2012) Authors response to scientific correspondence Neuropathology and Applied Neurobiology, 38(4), 381 - 381.
  45. Ozawa T,Revesz T,Paviour D,Lees AJ,Quinn N,Tada M,Kakita A,Onodera O,Wakabayashi K,Takahashi H,Nishizawa M,Holton JL (2012) Difference in MSA phenotype distribution between populations: Genetics or environment? Journal of Parkinson's Disease, 2(1), 7 - 18.
  46. Charlesworth G,Gandhi S,Bras JM,Barker RA,Burn DJ,Chinnery PF,Gentleman SM,Guerreiro R,Hardy J,Holton JL,Lees A,Morrison K,Sheerin U-M,Williams N,Morris H,Revesz T,Wood NW (2012) Tau acts as an independent genetic risk factor in pathologically proven PD Neurobiology of Aging, 33(4), 838.e7 - 838.e11.
  47. Charlesworth G,Gandhi S,Bras JM,Barker RA,Burn DJ,Chinnery PF,Gentleman SM,Guerreiro R,Hardy J,Holton JL,Lees A,Morrison K,Sheerin UM,Williams N,Morris H,Revesz T,Wood NW (2012) Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiol Aging, 33(4), 838.e7 - 838.11. 10.1016/j.neurobiolaging.2011.11.001.
  48. Ahmed Z,Asi YT,Sailer A,Lees AJ,Houlden H,Revesz T,Holton JL (2012) The neuropathology, pathophysiology and genetics of multiple system atrophy. Neuropathol Appl Neurobiol, 38(1), 4 - 24. 10.1111/j.1365-2990.2011.01234.x.
  49. Saul A,Lashley T,Revesz T,Holton J,Ghiso JA,Coomaraswamy J,Wirths O (2012) Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias Neurobiology of Aging.
  50. Schott JM,Warren JD,Rossor MN,Revesz T (2011) Open biopsy in patients with acute progressive neurologic decline and absence of mass lesion. Neurology, 76(21), 1847. 10.1212/WNL.0b013e318210e621.

Biography


Research

As an academic neuropathologist my research has mainly focused on understanding pathomechanism of neurodegenerative diseases. The major topics pursued in the past 12 years include:

1. Cerebral amyloid formation and neurodegeneration

  • Papers in Nature, Proc Natl Acad Sci, Brain, Ann Neurol, Am J Pathol, J Biol Chem, J Neuropathol Exp Neurol, Acta Neuropathol, Neuropathol Appl Neurobiol
2. Frontotemporal lobar degeneration

  • Papers in Brain, Acta Neuropathol, Neurology, Neuropathol Appl Neurobiol
3. Parkinson’s disease: disease spread, factors influencing disease manifestation

  • Papers in Nat Med, Nat Rev Neurosci, Lancet, Brain, Ann Neurol, Acta Neuropathol
4. Clinical, genetic, biochemical and pathological subgroups in progressive supranuclear palsy

  • Papers in Brain, Nat Genetics, Ann Neurol, Mov Disord, FEBS Lett
ResearcherID: http://www.researcherid.com/rid/A-8732-2010 

Qualifications

  • 1999: Fellow of the Royal College of Pathologists, Royal College of Pathologists, UK
  • 1990: Member of the Royal College of Pathologists, Royal College of Pathologists, UK
  • 1972: Doctor of Medicine, Semmelweis Medical School

Keywords

  • Alpha-synuclein
  • Alzheimer's disease
  • Amyloid
  • Confocal microscopy
  • Dementia
  • Dystonia
  • Electron Microscopy
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Histology
  • Image analysis
  • Light microscopic techniques
  • Movement disorders
  • Multiple system atrophy
  • Neurodegeneration
  • Neurodegenerative disease
  • Neuropathology
  • Parkinson's disease
  • Progressive Supranuclear Palsy
  • Stereological analysis