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Dr Shi-Yu Yang

Research Summary

Initially, I was studying the role of IGF-I in muscle development, growth and regeneration. The biggest accomplishment I have achieved in this field is successfully cloning the Mechano Growth Factor (MGF, an IGF-I isoform) from exercised muscle and demonstrated that MGF \"kick starts\" muscle hypertrophy and is important in local tissue repair. Following cloning MGF, I have directed my research on characterising this novel growth factor and its pharmaceutical applications. Based on my research, several highly active MGF C-peptides have been produced and marketed by biotech companies.

After marketing MGF, I have shifted my research towards the role of IGF-I signalling in solid cancer initiation, development and progress. Since then, I have made considerable progresses and demonstrated that IGF-I is implicated in colorectal cancer cell survival, migration and invasion. Based on the structure of IGF-I and its receptor, I have designed and developed an IGF-I receptor antagonist and established that this antagonist is able to disrupt the interaction between IGF-I and IGF-I receptor, and induce colorectal cancer cell apoptosis.

Research Activities

  • Colorectal Cancer Research Programme
  • Neuromuscular and Neurodegenerative Disorders

Recent Publications

Displaying 50 most recent publications. For the full list please visit UCL Discovery

  1. Knowles JP,Shi-Wen X,Haque SU,Bhalla A,Dashwood MR,Yang S,Taylor I,Winslet MC,Abraham DJ,Loizidou M (2012) Endothelin-1 stimulates colon cancer adjacent fibroblasts. Int J Cancer, 130(6), 1264 - 1272. 10.1002/ijc.26090.
  2. Klionsky DJ,Abdalla FC,Abeliovich H,Abraham RT,Acevedo-Arozena A,Adeli K,Agholme L,Agnello M,Agostinis P,Aguirre-Ghiso JA,Ahn HJ,Ait-Mohamed O,Ait-Si-Ali S,Akematsu T,Akira S,Al-Younes HM,Al-Zeer MA,Albert ML,Albin RL,Alegre-Abarrategui J,Aleo MF,Alirezaei M,Almasan A,Almonte-Becerril M,Amano A,Amaravadi R,Amarnath S,Amer AO,Andrieu-Abadie N,Anantharam V,Ann DK,Anoopkumar-Dukie S,Aoki H,Apostolova N,Arancia G,Aris JP,Asanuma K,Asare NYO,Ashida H,Askanas V,Askew DS,Auberger P,Baba M,Backues SK,Baehrecke EH,Bahr BA,Bai X-Y,Bailly Y,Baiocchi R,Baldini G,Balduini W,Ballabio A,Bamber BA,Bampton ETW,Bánhegyi G,Bartholomew CR,Bassham DC,Bast Jr RC,Batoko H,Bay B-H,Beau I,Béchet DM,Begley TJ,Behl C,Behrends C,Bekri S,Bellaire B,Bendall LJ,Benetti L,Berliocchi L,Bernardi H,Bernassola F,Besteiro S,Bhatia-Kissova I,Bi X,Biard-Piechaczyk M,Blum JS,Boise LH,Bonaldo P,Boone DL,Bornhauser BC,Bortoluci KR,Bossis I,Bost F,Bourquin J-P,Boya P,Boyer-Guittaut M,Bozhkov PV,Brady NR,Brancolini C,Brech A,Brenman JE,Brennand A,Bresnick EH,Brest P,Bridges D,Bristol ML,Brookes PS,Brown EJ,Brumell JH,Brunetti-Pierri N,Brunk UT,Bulman DE,Bultman SJ,Bultynck G,Burbulla LF,Bursch W,Butchar JP,Buzgariu W,Bydlowski SP,Cadwell K,Cahová M,Cai D,Cai J,Cai Q,Calabretta B,Calvo-Garrido J,Camougrand N,Campanella M,Campos-Salinas J,Candi E,Cao L,Caplan AB,Carding SR,Cardoso SM,Carew JS,Carlin CR,Carmignac V,Carneiro LAM,Carra S,Caruso RA,Casari G,Casas C,Castino R,Cebollero E,Cecconi F,Celli J,Chaachouay H,Chae H-J,Chai C-Y,Chan DC,Chan EY,Chang RC-C,Che C-M,Chen C-C,Chen G-C,Chen G-Q,Chen M,Chen Q,Chen SS-L,Chen W,Chen X,Chen Y-G,Chen Y,Chen Y-J,Chen Z,Cheng A,Cheng CHK,Cheng Y,Cheong H,Cheong J-H,Cherry S,Chess-Williams R,Cheung ZH,Chevet E,Chiang H-L,Chiarelli R,Chiba T,Chin L-S,Chiou S-H,Chisari FV,Cho CH,Cho D-H,Choi AMK,Choi D,Choi KS,Choi ME,Chouaib S,Choubey D,Choubey V,Chu CT,Chuang T-H,Chueh S-H,Chun T,Chwae Y-J,Chye M-L,Ciarcia R,Ciriolo MR,Clague MJ,Clark RSB,Clarke PGH,Clarke R,Codogno P,Coller HA,Colombo MI,Comincini S,Condello M,Condorelli F,Cookson MR,Coombs GH,Coppens I,Corbalan R,Cossart P,Costelli P,Costes S,Coto-Montes A,Couve E,Coxon FP,Cregg JM,Crespo JL,Cronjé MJ,Cuervo AM,Cullen JJ,Czaja MJ,D'Amelio M,Darfeuille-Michaud A,Davids LM,Davies FE,De Felici M,De Groot JF,De Haan CAM,De Martino L,De Milito A,De Tata V,Debnath J,Degterev A,Dehay B,Delbridge LMD,Demarchi F,Deng YZ,Dengjel J,Dent P,Denton D,Deretic V,Desai SD,Devenish RJ,Di Gioacchino M,Di Paolo G,Di Pietro C,Díaz-Araya G,Díaz-Laviada I,Diaz-Meco MT,Diaz-Nido J,Dikic I,Dinesh-Kumar SP,Ding W-X,Distelhorst CW,Diwan A,Djavaheri-Mergny M,Dokudovskaya S,Dong Z,Dorsey FC,Dosenko V,Dowling JJ,Doxsey S,Dreux M,Drew ME,Duan Q,Duchosal MA,Duff K,Dugail I,Durbeej M,Duszenko M,Edelstein CL,Edinger AL,Egea G,Eichinger L,Eissa NT,Ekmekcioglu S,El-Deiry WS,Elazar Z,Elgendy M,Ellerby LM,Er Eng K,Engelbrecht A-M,Engelender S,Erenpreisa J,Escalante R,Esclatine A,Eskelinen E-L,Espert L,Espina V,Fan H,Fan J,Fan Q-W,Fan Z,Fang S,Fang Y,Fanto M,Fanzani A,Farkas T,Farré J-C,Faure M,Fechheimer M,Feng CG,Feng J,Feng Q,Feng Y,Fésüs L,Feuer R,Figueiredo-Pereira ME,Fimia GM,Fingar DC,Finkbeiner S,Finkel T,Finley KD,Fiorito F,Fisher EA,Fisher PB,Flajolet M,Florez-McClure ML,Florio S,Fon EA,Fornai F,Fortunato F,Fotedar R,Fowler DH,Fox HS,Franco R,Frankel LB,Fransen M,Fuentes JM,Fueyo J,Fujii J,Fujisaki K,Fujita E,Fukuda M,Furukawa RH,Gaestel M,Gailly P,Gajewska M,Galliot B,Galy V,Ganesh S,Ganetzky B,Ganley IG,Gao F-B,Gao G (2012) Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy, 8(4), 445 - 544.
  3. Alagaratnam S,Johnson A,Seifalian A,Winslet M,Yang S (2012) Autophagy in cancer cells as a pro-survival mechanism BRITISH JOURNAL OF SURGERY, 99, 105 - 106.
  4. Abu-Amara M,Yang SY,Seifalian A,Davidson B,Fuller B (2012) The nitric oxide pathway--evidence and mechanisms for protection against liver ischaemia reperfusion injury. Liver Int, 32(4), 531 - 543. 10.1111/j.1478-3231.2012.02755.x.
  5. Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A (2012) The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injury. Transplantation, 93(9), 880 - 886. 10.1097/TP.0b013e31824cd59d.
  6. Pabari A,Yang SY,Mosahebi A,Seifalian AM (2011) Recent advances in artificial nerve conduit design: strategies for the delivery of luminal fillers. J Control Release, 156(1), 2 - 10. 10.1016/j.jconrel.2011.07.001.
  7. Pabari A,Yang SY,Butler P,Mosahebi A,Seifalian AM (2011) Differentiation of schwann cells on a novel nanocomposite material for peripheral nerve regeneration BRITISH JOURNAL OF SURGERY, 98(6), E13 - E13.
  8. Rogge FJ,Kerdjoudj H,Yang SY,Seifalian AM,Grobbelaar AO (2011) In vivo engineering of a myotendinous junction: a cornerstone in skeletal muscle tissue engineering BRITISH JOURNAL OF SURGERY, 98(6), E12 - E12.
  9. Yang SY,Winslet MC (2011) Dual role of autophagy in colon cancer cell survival. Ann Surg Oncol, 18 Suppl 3, S239. 10.1245/s10434-011-1789-x.
  10. Abu-Amara M,Yang SY,Seifalian AM,Fuller B,Davidson BR (2011) Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/reperfusion injury. Ann Surg, 254(1), 178 - 180. 10.1097/SLA.0b013e318221ff34.
  11. Abu-Amara M,Yang SY,Quaglia A,Rowley P,Fuller B,Seifalian A,Davidson B (2011) Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver. Liver Transpl, 17(5), 610 - 619. 10.1002/lt.22272.
  12. Abu-Amara M,Yang SY,Quaglia A,Rowley P,de Mel A,Tapuria N,Seifalian A,Davidson B,Fuller B (2011) Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury. Clin Sci (Lond), 121(6), 257 - 266. 10.1042/CS20100598.
  13. Miah A,Yang SY,Winslet M (2011) AKT pathway as a potential therapeutic target for treating metastatic colorectal cancer BRITISH JOURNAL OF SURGERY, 98, 39 - 39.
  14. Bartnik A,Yang SY,Miah A,Chen YW,Winslet M (2011) Autophagy protects colon cancer cells against stress-induced death BRITISH JOURNAL OF SURGERY, 98, 12 - 12.
  15. Rippel RA,Nayyer L,Yang SY,Birchall M,Butler P,Seifalian AM (2011) Development of scaffold for auricular tissue engineering using a novel nanocomposite polymer BRITISH JOURNAL OF SURGERY, 98, 58 - 58.
  16. Pabari A,Sedaghati T,Yang SY,Butler P,Mosahebi A,Seifalian AM (2011) Differentiation of adipose derived stem cells to Schwann cells on a novel nanocomposite polymer BRITISH JOURNAL OF SURGERY, 98, 59 - 59.
  17. Abu-Amara M,Yang SY,Seifalian A,Davidson B,Fuller B (2011) REMOTE ISCHAEMIC PRECONDITIONING PROTECTS THE HEPATIC MICROCIRCULATION FROM LIVER ISCHAEMIA REPERFUSION INJURY THROUGH THE NITRIC OXIDE/cyclicGMP PATHWAY TRANSPL INT, 24, 7 - 7.
  18. Sedaghati T,Yang SY,Mosahebi A,Alavijeh MS,Seifalian AM (2011) Nerve regeneration with aid of nanotechnology and cellular engineering. Biotechnol Appl Biochem, 58(5), 288 - 300. 10.1002/bab.51.
  19. Abu-Amara M,Yang S,Seifalian A,Fuller B,Davidson B (2011) Remote Ischemic Preconditioning Protects the Liver from Ischemia Reperfusion Injury through the sGC-cGMP Pathway AMERICAN JOURNAL OF GASTROENTEROLOGY, 106, S106 - S106.
  20. Abu-Amara M,Yang S,Seifalian A,Fuller B,Davidson B (2011) Nitric Oxide in Remote Ischemic Preconditioning of the Liver: A Novel Role for an Old Molecule AMERICAN JOURNAL OF GASTROENTEROLOGY, 106, S105 - S105.
  21. Yang SY,Winslet M (2011) The igf system in carcinogenesis and its implication for cancer therapy. Curr Oncol, 18(6), 301 - 302.
  22. Chan YW,Miah A,Bartnik A,Fuller B,Winslet M,Yang SY (2011) The role of P38 MAPK pathway in human colon cancer cell resistance to 5-Fluorouracil. British Journal of Surgery, 98(S2), 12 - 12. 10.1002/bjs.7521.
  23. Abu-Amara M,Yang S,Tapuria N,Fuller BJ,Davidson BR,Seifalian AM (2011) Reply. Liver Transpl, 17(1), 96. 10.1002/lt.22215.
  24. Yang SY,Miah A,Pabari A,Winslet M (2011) Growth Factors and their receptors in cancer metastases. Front Biosci, 16, 531 - 538.
  25. Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Seifalian AM,Fuller BJ,Davidson BR (2011) Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model. Liver Transpl, 17(1), 70 - 82. 10.1002/lt.22204.
  26. Bartnik A,Loizidou M,Winslet MC,Yang SY (2011) Autophagy and Colorectal Cancer Therapy Oncology News, 5(6), 188 - 189.
  27. Yang SY,Miah A,Sales KM,Fuller B,Seifalian AM,Winslet M (2011) Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatment. Int J Oncol, 38(6), 1695 - 1702. 10.3892/ijo.2011.982.
  28. Miah A,Yang SY,Winslet M (2010) Akt Pathway is involoved in colon cancer cell migration European Journal of Surgical Oncology, 36(11), 1128 - 1129.
  29. Taribagil S,Yang SY,Ramesh B,Seifalian AM,Winslet MC (2010) Conjugation of quantum dots with RGD peptides: colon cancer cell targeting and toxicity assay BRITISH JOURNAL OF SURGERY, 97, 45 - 45.
  30. Rizvi SB,Green M,Darbyshire A,YANG S,Seifalian AM,Keshtgar M (2010) Development of a biocompatible fluorescent nanocrystal for sentinal lymph node biopsy British Journal of Surgery, 97(S6), 19 - 19. 10.1002/bjs.7351.
  31. Miah A,Yang SY,Hoy M,Vasas P,Winslet M (2010) Inhibition of P38 MAPK sensitizes human colorectal cancer cells to 5-fluorouracil treatment British Journal of Surgery, 97(6S), 32 - 32. 10.1002/bjs.7351.
  32. Vasas P,Winslet M,Yang SY (2010) Interfering with IGF-I pathways to augment sensitivity of colon cancer cells to current chemotherapeutic agents British Journal of Surgery, 97(S6), 34 - 34. 10.1002/bjs.7351.
  33. Abu-Amara M,Yang SY,Seifalian AM,Davidson BR,Fuller B (2010) Mouse hindlimb remote ischaemic preconditioning reduces liver ischaemia reperfusion injury and improves microcirculatory blood flow British Journal of Surgery, 97(S6), 38 - 38. 10.1002/bjs.7351.
  34. Yang SY (2010) IGF IS A MAJOR PHYSIOLOGICAL REGULATOR, BUT NOT SOLELY RESPONSIBLE FOR MUSCLE MASS REGULATION J APPL PHYSIOL, 108(6), 1826 - 1826.
  35. Yang SY,Miah A,Hoy M,Winslet M (2010) The tretment of colorectal cancer metastasis with IGF-I receptor antagonists British Journal of Surgery, 97(S6), 16 - 16. 10.1002/bjs.7351.
  36. Abu-Amara M,Yang S,Fuller B,Davidson B (2010) Hind limb remote ischaemic preconditioning induces hepatic iNOS expression leading to protection against liver IR injury BRITISH JOURNAL OF SURGERY, 97, 80 - 80.
  37. Pabari A,Yang SY,Seifalian AM,Mosahebi A (2010) Modern surgical management of peripheral nerve gap. J Plast Reconstr Aesthet Surg, 63(12), 1941 - 1948. 10.1016/j.bjps.2009.12.010.
  38. Yang SY,Hoy M,Fuller B,Sales KM,Seifalian AM,Winslet MC (2010) Pretreatment with insulin-like growth factor I protects skeletal muscle cells against oxidative damage via PI3K/Akt and ERK1/2 MAPK pathways. Lab Invest, 90(3), 391 - 401. 10.1038/labinvest.2009.139.
  39. Kumar Y,Mazurek S,Yang S,Failing K,Winslet M,Fuller B,Davidson BR (2010) In vivo factors influencing tumour M2-pyruvate kinase level in human pancreatic cancer cell lines. Tumour Biol, 31(2), 69 - 77. 10.1007/s13277-009-0010-3.
  40. Abu-Amara M,Yang SY,Tapuria N,Fuller B,Davidson B,Seifalian A (2010) Liver ischemia/reperfusion injury: processes in inflammatory networks--a review. Liver Transpl, 16(9), 1016 - 1032. 10.1002/lt.22117.
  41. Abu-Amara M,Yang SY,Seifalian AM,Davidson BR,Fuller B (2010) Nitric oxide and endothelial nitric oxide synthase activity are a prerequisite for the protective effect of hindlimb remote ischaemic preconditioning on liver ischaemia reperfusion injury British Journal of Surgery, 97(S6), 30 - 30. 10.1002/bjs.7351.
  42. Li W,Yang SY,Hu ZF,Winslet MC,Wang W,Seifalian AM (2009) Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions. Med Sci Monit, 15(12), BR357 - BR363.
  43. Yang SY,Sales KM,Fuller B,Seifalian AM,Winslet MC (2009) Apoptosis and colorectal cancer: implications for therapy. Trends Mol Med, 15(5), 225 - 233. 10.1016/j.molmed.2009.03.003.
  44. Riddoch-Contreras J,Yang SY,Dick JRT,Goldspink G,Orrell RW,Greensmith L (2009) Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice Experimental Neurology, 215(2), 281 - 289. 10.1016/j.expneurol.2008.10.014.
  45. Yang SY,Winslet MC (2009) Apoptosis in Colorectal Tumorigenesis and Chemotherapy, 75 - 109.
  46. Robertson JH,Yang SY,Winslet MC,Seifalian AM (2009) Functional blocking of specific integrins inhibit colonic cancer migration. Clin Exp Metastasis, 26(7), 769 - 780. 10.1007/s10585-009-9276-5.
  47. Yang SY,Bolvin C,Sales KM,Fuller B,Seifalian AM,Winslet MC (2009) IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cells. BMC Cancer, 9, 158. 10.1186/1471-2407-9-158.
  48. Vasas P,Winslet MC,Yang SY (2009) The role of insulin-like growth factors (IGF) in cell division processes and in malignancy | Az inzulinszeru″ növekedési faktor (IGF) szerepe a sejtosztódási folyamatokban és a daganatokban Orvosi Hetilap, 150(51), 2308 - 2312.
  49. Yang SY,Sales KM,Fuller BJ,Seifalian AM,Winslet MC (2008) Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptide Molecular Cancer, 7.
  50. Durai R,Yang SY,Seifalian AM,Winslet MC (2008) Principles and applications of gene therapy in colon cancer Journal of Gastrointestinal and Liver Diseases, 17(1), 59 - 67.

Qualifications

  • 1996: Doctor of Philosophy, University College London
  • 1984: Master of Veterinary Science, Northwestern Agricultural University, Shaanxi
  • 1982: Bachelor of Science, Shanxi Agricultural University